Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Flávia S. Donaires"'
Autor:
Maria Florencia Tellechea, Flávia S. Donaires, Vinícius S. de Carvalho, Bárbara A. Santana, Fernanda B. da Silva, Raissa S. Tristão, Lílian F. Moreira, Aline F. de Souza, Yordanka M. Armenteros, Lygia V. Pereira, Rodrigo T. Calado
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-8 (2022)
Abstract In acquired immune aplastic anemia (AA), pathogenic cytotoxic Th1 cells are activated and expanded, driving an immune response against the hematopoietic stem and progenitor cells (HSPCs) that provokes cell depletion and causes bone marrow fa
Externí odkaz:
https://doaj.org/article/bb56f09a3dec4426be5a1ce98a1c4565
Autor:
Diego V. Clé, Luiz Fernando B. Catto, Fernanda Gutierrez-Rodrigues, Flávia S. Donaires, Andre L. Pinto, Barbara A. Santana, Luiz Guilherme Darrigo, Elvis T. Valera, Marcel Koenigkam-Santos, José Baddini-Martinez, Neal S. Young, Edson Z. Martinez, Rodrigo T. Calado
Publikováno v:
Haematologica, Vol 108, Iss 5 (2022)
Androgens have been reported to elongate telomeres in retrospective and prospective trials with patients with telomeropathies, mainly with bone marrow failure. In our single-arm prospective clinical trial (clinicaltrials gov. Identifier: NCT02055456)
Externí odkaz:
https://doaj.org/article/f91b0737ad70442dbf80c6919fd4d34c
Autor:
Judith C.W. Marsh, Fernanda Gutierrez-Rodrigues, James Cooper, Jie Jiang, Shreyans Gandhi, Sachiko Kajigaya, Xingmin Feng, Maria del Pilar F. Ibanez, Flávia S. Donaires, João P. Lopes da Silva, Zejuan Li, Soma Das, Maria Ibanez, Alexander E. Smith, Nicholas Lea, Steven Best, Robin Ireland, Austin G. Kulasekararaj, Donal P. McLornan, Anthony Pagliuca, Isabelle Callebaut, Neal S. Young, Rodrigo T. Calado, Danielle M. Townsley, Ghulam J Mufti
Publikováno v:
Blood Advances, Vol 2, Iss 1, Pp 36-48 (2018)
Abstract: Biallelic germline mutations in RTEL1 (regulator of telomere elongation helicase 1) result in pathologic telomere erosion and cause dyskeratosis congenita. However, the role of RTEL1 mutations in other bone marrow failure (BMF) syndromes an
Externí odkaz:
https://doaj.org/article/ed241c993a0c49d0916d090e2dcddf29
Autor:
Flavia S. Donaires, Raquel M. Alves-Paiva, Fernanda Gutierrez-Rodrigues, Fernanda Borges da Silva, Maria Florencia Tellechea, Lilian Figueiredo Moreira, Barbara A. Santana, Fabiola Traina, Cynthia E. Dunbar, Thomas Winkler, Rodrigo T. Calado
Publikováno v:
Stem Cell Research, Vol 40, Iss , Pp - (2019)
Telomeropathies are a group of phenotypically heterogeneous diseases molecularly unified by pathogenic mutations in telomere-maintenance genes causing critically short telomeres. X-linked dyskeratosis congenita (DC), the prototypical telomere disease
Externí odkaz:
https://doaj.org/article/60602e6054164d98bb0983f5d0e635ef
Autor:
Flávia S Donaires, Natália F Scatena, Raquel M Alves-Paiva, Joshua D Podlevsky, Dhenugen Logeswaran, Barbara A Santana, Andreza C Teixeira, Julian J-L Chen, Rodrigo T Calado, Ana L C Martinelli
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183287 (2017)
Telomeres are repetitive DNA sequences at linear chromosome termini, protecting chromosomes against end-to-end fusion and damage, providing chromosomal stability. Telomeres shorten with mitotic cellular division, but are maintained in cells with high
Externí odkaz:
https://doaj.org/article/eff92107e14f4c0bad8391e108f36032