Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α

Autor: Maria Alice Freitas Queiroz, Wandrey Roberto dos Santos Brito, Keise Adrielle Santos Pereira, Leonn Mendes Soares Pereira, Ednelza da Silva Graça Amoras, Sandra Souza Lima, Erika Ferreira dos Santos, Flávia Póvoa da Costa, Kevin Matheus Lima de Sarges, Marcos Henrique Damasceno Cantanhede, Mioni Thieli Figueiredo Magalhães de Brito, Andréa Luciana Soares da Silva, Mauro de Meira Leite, Maria de Nazaré do Socorro de Almeida Viana, Fabíola Brasil Barbosa Rodrigues, Rosilene da Silva, Giselle Maria Rachid Viana, Tânia do Socorro Souza Chaves, Adriana de Oliveira Lameira Veríssimo, Mayara da Silva Carvalho, Daniele Freitas Henriques, Carla Pinheiro da Silva, Juliana Abreu Lima Nunes, Iran Barros Costa, Izaura Maria Vieira Cayres-Vallinoto, Igor Brasil-Costa, Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão, Eduardo José Melo dos Santos, Antonio Carlos Rosário Vallinoto

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract The cGAS-STING pathway appears to contribute to dysregulated inflammation during coronavirus disease 2019 (COVID-19); however, inflammatory factors related to long COVID are still being investigated. In the present study, we evaluated the as

Externí odkaz: https://doaj.org/article/e6c8d11d0532469cb353e5e2332e0034

Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19

Autor: Maria Alice Freitas Queiroz, Angélica Menezes Santiago, Wandrey Roberto dos Santos Brito, Keise Adrielle Santos Pereira, William Botelho de Brito, Maria Karoliny da Silva Torres, Jeferson da Costa Lopes, Erika Ferreira dos Santos, Flávia Póvoa da Costa, Kevin Matheus Lima de Sarges, Marcos Henrique Damasceno Cantanhede, Mioni Thieli Figueiredo Magalhães de Brito, Andréa Luciana Soares da Silva, Mauro de Meira Leite, Maria de Nazaré do Socorro de Almeida Viana, Fabíola Brasil Barbosa Rodrigues, Rosilene da Silva, Giselle Maria Rachid Viana, Tânia do Socorro Souza Chaves, Adriana de Oliveira Lameira Veríssimo, Mayara da Silva Carvalho, Daniele Freitas Henriques, Carla Pinheiro dos Santos, Juliana Abreu Lima Nunes, Iran Barros Costa, Ednelza da Silva Graça Amoras, Sandra Souza Lima, Izaura Maria Vieira Cayres-Vallinoto, Igor Brasil-Costa, Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão, Eduardo José Melo dos Santos, Antonio Carlos Rosário Vallinoto

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionMannose-binding lectin (MBL) promotes opsonization, favoring phagocytosis and activation of the complement system in response to different microorganisms, and may influence the synthesis of inflammatory cytokines. This study investigated

Externí odkaz: https://doaj.org/article/9eb7f27cc2f3400b8af118e61c11f094

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population

Autor: Fabíola Brasil Barbosa Rodrigues, Rosilene da Silva, Erika Ferreira dos Santos, Mioni Thieli Figueiredo Magalhães de Brito, Andréa Luciana Soares da Silva, Mauro de Meira Leite, Flávia Póvoa da Costa, Maria de Nazaré do Socorro de Almeida Viana, Kevin Matheus Lima de Sarges, Marcos Henrique Damasceno Cantanhede, Adriana de Oliveira Lameira Veríssimo, Mayara da Silva Carvalho, Daniele Freitas Henriques, Carla Pinheiro da Silva, Igor Brasil Costa, Juliana Abreu Lima Nunes, Iran Barros Costa, Giselle Maria Rachid Viana, Maria Alice Freitas Queiroz, Sandra Souza Lima, Jeferson da Costa Lopes, Maria Karoliny da Silva Torres, Izaura Maria Vieira Cayres Vallinoto, Carlos David Araújo Bichara, Antonio Carlos Rosário Vallinoto, Eduardo José Melo dos Santos

Publikováno v: Viruses, Vol 15, Iss 5, p 1197 (2023)

Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an important regulator of the cytokine storm. Hence, the evaluation of the influence of polymorphisms in key genes of the IL-6 pathway, namely IL6, IL6R, and IL6ST,

Externí odkaz: https://doaj.org/article/9d3ba056670a4711b3c0fc48df07d3e6

Antibody Response to the SARS-CoV-2 Spike and Nucleocapsid Proteins in Patients with Different COVID-19 Clinical Profiles

Autor: Sinei Ramos Soares, Maria Karoliny da Silva Torres, Sandra Souza Lima, Kevin Matheus Lima de Sarges, Erika Ferreira dos Santos, Mioni Thieli Figueiredo Magalhães de Brito, Andréa Luciana Soares da Silva, Mauro de Meira Leite, Flávia Póvoa da Costa, Marcos Henrique Damasceno Cantanhede, Rosilene da Silva, Adriana de Oliveira Lameira Veríssimo, Izaura Maria Vieira Cayres Vallinoto, Rosimar Neris Martins Feitosa, Juarez Antônio Simões Quaresma, Tânia do Socorro Souza Chaves, Giselle Maria Rachid Viana, Luiz Fábio Magno Falcão, Eduardo José Melo dos Santos, Antonio Carlos Rosário Vallinoto, Andréa Nazaré Monteiro Rangel da Silva

Publikováno v: Viruses, Vol 15, Iss 4, p 898 (2023)

The first case of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in Brazil was diagnosed on February 26, 2020. Due to the important epidemiological impact of COVID-19, the present study ai

Externí odkaz: https://doaj.org/article/d94907565af34f9ca3ca910ecb21ae09

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

Autor: Bruna Puty, Sávio Monteiro dos Santos, Manoela Domingues Martins, Edivaldo Herculano Corrêa de Oliveira, Carlos Augusto Galvão Barboza, Bruno José Brito Teixeira, Rafael Rodrigues Lima, Geovanni Pereira Mitre, Hervé Rogez, Maria Sueli da Silva Kataoka, Lygia Sega Nogueira, Marta Chagas Monteiro, Flávia Póvoa da Costa

Publikováno v: Antioxidants, Vol 9, Iss 1, p 16 (2019)
Antioxidants
Volume 9
Issue 1
Repositório Digital do Instituto Evandro Chagas (Patuá)
Instituto Evandro Chagas (IEC)
instacron:IEC
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS

Piceatannol is a resveratrol metabolite that is considered a potent antioxidant and cytoprotector because of its high capacity to chelate/sequester reactive oxygen species. In pathogenesis of periodontal diseases, the imbalance of reactive oxygen spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a38b21f2f4a345a38f112b2a20ebf4
https://www.mdpi.com/2076-3921/9/1/16