Výsledky vyhledávání - "Flávia A, Graça"

Akademický článek

Insulin/IGF1 signalling mediates the effects of β2‐adrenergic agonist on muscle proteostasis and growth

Autor: Dawit A. Gonçalves, Wilian A. Silveira, Leandro H. Manfredi, Flávia A. Graça, Andrea Armani, Enrico Bertaggia, Brian T. O´Neill, Natalia Lautherbach, Juliano Machado, Leonardo Nogara, Marcelo G. Pereira, Diletta Arcidiacono, Stefano Realdon, C. Ronald Kahn, Marco Sandri, Isis C. Kettelhut, Luiz Carlos C. Navegantes

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 2, Pp 455-475 (2019)

Abstract Background Stimulation of β2‐adrenoceptors can promote muscle hypertrophy and fibre type shift, and it can counteract atrophy and weakness. The underlying mechanisms remain elusive. Methods Fed wild type (WT), 2‐day fasted WT, muscle‐

Externí odkaz: https://doaj.org/article/f341a8776db04f97b5771d9cee49e3e4

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Insulin/IGF1 signalling mediates the effects of β 2 ‐adrenergic agonist on muscle proteostasis and growth

Autor: Flávia A. Graça, C. Ronald Kahn, Brian T O Neill, Wilian A. Silveira, Diletta Arcidiacono, Luiz Carlos Carvalho Navegantes, Natalia Lautherbach, Leonardo Nogara, Andrea Armani, Marco Sandri, Stefano Realdon, L. H. Manfredi, Dawit A. P. Gonçalves, Isis do Carmo Kettelhut, Enrico Bertaggia, Juliano Machado, Marcelo G. Pereira

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 2, Pp 455-475 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da UFMG
Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG

CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior FAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo Outra Agência Background: Stimulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8522d9bd923d25725b2b9f76a5d876
https://doi.org/10.1002/jcsm.12395

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Activating cAMP/PKA signaling in skeletal muscle suppresses the ubiquitin-proteasome-dependent proteolysis: implications for sympathetic regulation

Autor: Ana Luiza Andrade-Lopes, Leandro Bueno Bergantin, Luiz Carlos Carvalho Navegantes, Rosely Oliveira Godinho, Flávia A. Graça, Isis do Carmo Kettelhut, Neusa Maria Zanon, Dawit A. P. Gonçalves, Wilian A. Silveira

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Although we have recently demonstrated that plasma catecholamines induce antiproteolytic effects on skeletal muscle (Graça FA, Gonçalves DAP, Silveira WA, Lira EC, Chaves VE, Zanon NM, Garófalo MAR, Kettelhut IC, Navegantes LCC. Am J Physiol Endoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc868542c53df729cd930fea5c10a79
https://doi.org/10.1152/japplphysiol.01055.2013

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Epinephrine depletion exacerbates the fasting-induced protein breakdown in fast-twitch skeletal muscles

Autor: Isis do Carmo Kettelhut, Valéria Ernestânia Chaves, Eduardo Carvalho Lira, Neusa Maria Zanon, Wilian A. Silveira, Flávia A. Graça, Dawit A. P. Gonçalves, Maria Antonieta Rissato Garófalo, Luiz Carlos Carvalho Navegantes

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The physiological role of epinephrine in the regulation of skeletal muscle protein metabolism under fasting is unknown. We examined the effects of plasma epinephrine depletion, induced by adrenodemedullation (ADMX), on muscle protein metabolism in fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f3ad2b4464c0667eebfa781fa44a91
https://doi.org/10.1152/ajpendo.00267.2013

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Clenbuterol suppresses proteasomal and lysosomal proteolysis and atrophy-related genes in denervated rat soleus muscles independently of Akt

Autor: Flávia A. Graça, Silvia Paula-Gomes, Neusa Maria Zanon, Luiz Carlos Carvalho Navegantes, Eduardo Carvalho Lira, Isis do Carmo Kettelhut, Wilian A. Silveira, Dawit A. P. Gonçalves

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 302:E123-E133

Although it is well known that administration of the selective β2-adrenergic agonist clenbuterol (CB) protects muscle following denervation (DEN), the underlying molecular mechanism remains unclear. We report that in vivo treatment with CB (3 mg/kg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332ad0880137e251c814b6af6d803045
https://doi.org/10.1152/ajpendo.00188.2011

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CYCLIC ADENOSINE MONOPHOSPHATE-PHOSPHODIESTERASE INHIBITORS REDUCE SKELETAL MUSCLE PROTEIN CATABOLISM IN SEPTIC RATS

Autor: Neusa Maria Zanon, Luiz Carlos Carvalho Navegantes, Eduardo Carvalho Lira, Renato H. Migliorini, Lena Strindberg, Peter Lönnroth, Flávia A. Graça, Dawit A. P. Gonçalves, Amanda Martins Baviera, Isis do Carmo Kettelhut

Publikováno v: Shock. 27:687-694

We have previously shown that catecholamines exert an inhibitory effect on muscle protein degradation through a pathway involving the cyclic adenosine monophosphate (cAMP) cascade in normal rats. In the present work, we investigated in vivo and in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35ea5332b3ceffe4a9dfc6a7b192769
https://doi.org/10.1097/shk.0b013e31802e43a6

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Morphological and molecular aspects of immobilization-induced muscle atrophy in rats at different stages of postnatal development: the role of autophagy

Autor: Ana Claudia Mattiello-Sverzut, Wilian A. Silveira, Dawit A. P. Gonçalves, Isis do Carmo Kettelhut, Flávia A. Graça, Camila Silva Foresto, Silvia Paula-Gomes

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Muscle loss occurs following injury and immobilization in adulthood and childhood, which impairs the rehabilitation process; however, far fewer studies have been conducted analyzing atrophic response in infants. This work investigated first the morph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517b9e186ef72824caef95ae42918b01
https://pubmed.ncbi.nlm.nih.gov/27445301

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ß 2 ‐Adrenergic Agonist Suppresses Foxo Transcriptional Activity by Regulating Foxo1 Phosphorylation but not Acetylation in Skeletal Muscle

Autor: Flávia A. Graça, Danilo Lustrino, Dawit A. P. Gonçalves, L. H. Manfredi, Isis do Carmo Kettelhut, Luiz Carlos Carvalho Navegantes, Wilian A. Silveira

Publikováno v: The FASEB Journal. 29

This study was undertaken to identify: 1) whether s2-adrenergic agonist (BA) suppresses Foxo transcriptional activity and the expression of atrophy-related genes (atrogenes) in skeletal muscles and 2) which post-translational modification [i.e., phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a551feaadbb54fcb2af1cd3753cbd7e
https://doi.org/10.1096/fasebj.29.1_supplement.lb702

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