Zobrazeno 1 - 10
of 720
pro vyhledávání: '"Fkbp51"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Saskia Wedel, Lisa Hahnefeld, Yannick Schreiber, Christian Namendorf, Tim Heymann, Manfred Uhr, Mathias V. Schmidt, Natasja de Bruin, Felix Hausch, Dominique Thomas, Gerd Geisslinger, Marco Sisignano
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-21 (2023)
Abstract Background Chemotherapy-induced neuropathic pain (CIPN) describes a pathological pain state that occurs dose-dependently as a side effect and can limit or even impede an effective cancer therapy. Unfortunately, current treatment possibilitie
Externí odkaz:
https://doaj.org/article/7393b95fee1a48c09212292b2adeaadf
Autor:
Saskia Wedel, Praveen Mathoor, Oliver Rauh, Tim Heymann, Cosmin I. Ciotu, Dominik C. Fuhrmann, Michael J. M. Fischer, Andreas Weigert, Natasja de Bruin, Felix Hausch, Gerd Geisslinger, Marco Sisignano
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-21 (2022)
Abstract Background Neuropathic pain is experienced worldwide by patients suffering from nerve injuries, infectious or metabolic diseases or chemotherapy. However, the treatment options are still limited because of low efficacy and sometimes severe s
Externí odkaz:
https://doaj.org/article/a1ae3ff5437d4071b8e640f89f13be07
Autor:
Yu-Ling Gan, Chen-Yu Wang, Rong-Heng He, Pei-Chien Hsu, Hsin-Hsien Yeh, Tsung-Han Hsieh, Hui-Ching Lin, Ming-Yen Cheng, Chung-Jiuan Jeng, Ming-Chyi Huang, Yi-Hsuan Lee
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-21 (2022)
Abstract Background Inflammation is a potential risk factor of mental disturbance. FKBP5 that encodes FK506-binding protein 51 (FKBP51), a negative cochaperone of glucocorticoid receptor (GR), is a stress-inducible gene and has been linked to psychia
Externí odkaz:
https://doaj.org/article/c879189580ec4a1f8000b3c9bf60c8c3
Autor:
Lea M. Brix, Irmak Toksöz, London Aman, Veronika Kovarova, Margherita Springer, Joeri Bordes, Lotte van Doeselaar, Clara Engelhardt, Alexander S. Häusl, Sowmya Narayan, Vera Sterlemann, Huanqing Yang, Jan M. Deussing, Mathias V. Schmidt
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101579- (2022)
Objective: Steroidogenic factor 1 (SF1) expressing neurons in the ventromedial hypothalamus (VMH) have been directly implicated in whole-body metabolism and in the onset of obesity. The co-chaperone FKBP51 is abundantly expressed in the VMH and was r
Externí odkaz:
https://doaj.org/article/132b10c1b3664edd9b152209aa99d266
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
S. Mark Roe, Zsolt Török, Andrew McGown, Ibolya Horváth, John Spencer, Tamás Pázmány, László Vigh, Chrisostomos Prodromou
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1051 (2023)
Functional changes in chaperone systems play a major role in the decline of cognition and contribute to neurological pathologies, such as Alzheimer’s disease (AD). While such a decline may occur naturally with age or with stress or trauma, the mech
Externí odkaz:
https://doaj.org/article/08be2b23ecf04e69a5cf2cce0b6b8737
Autor:
Huanxin Sun, Xiaowen Liu, Laicheng Wang, Bin Cui, Wenli Mu, Yu Xia, Shuang Liu, Xin Liu, Yulian Jiao, Yueran Zhao
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
In this study, we demonstrated that the expression of FK506 binding protein 51 (FKBP51) is upregulated in acute monocytic leukemia (AML-M5) cells by dexamethasone and aimed to investigate the possible effects of FKBP51 on the growth and cytarabine se
Externí odkaz:
https://doaj.org/article/018f8b8e0ebe45f595df2d7ec5ca51d4
Autor:
Jian-Ting Han, Yongchang Zhu, Da-Bo Pan, Hong-Xiang Xue, Shuang Wang, Yali Peng, Huanxiang Liu, Yong-Xing He, Xiaojun Yao
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4079-4091 (2021)
FKBP51 is well-known as a cochaperone of Hsp90 machinery and implicated in many human diseases including stress-related diseases, tau-mediated neurodegeneration and cancers, which makes FKBP51 an attractive drug target for the therapy of FKBP51-assoc
Externí odkaz:
https://doaj.org/article/a392da26029f42f29b25a5ef26456ff0
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.