Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Fjodor Melnikov"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 635 (2022)
Due to challenges with historical data and the diversity of assay formats, in silico models for safety-related endpoints are often based on discretized data instead of the data on a natural continuous scale. Models for discretized endpoints have limi
Externí odkaz:
https://doaj.org/article/3cc17497624a46198ef8c8bbec3aa944
Autor:
Karolina E. Mellor, Philip Coish, Bryan W. Brooks, Evan P. Gallagher, Margaret Mills, Terrance J. Kavanagh, Nancy Simcox, Grace A. Lasker, Dianne Botta, Adelina Voutchkova-Kostal, Jakub Kostal, Melissa L. Mullins, Suzanne M. Nesmith, Jone Corrales, Lauren Kristofco, Gavin Saari, W. Baylor Steele, Fjodor Melnikov, Julie B. Zimmerman, Paul T. Anastas
Publikováno v:
Green Chemistry Letters and Reviews, Vol 11, Iss 2, Pp 103-110 (2018)
Green chemistry can strongly attract students to chemistry. We, therefore, developed a green chemistry educational game that motivates students at the undergraduate and advanced high school levels to consider green chemistry and sustainability concer
Externí odkaz:
https://doaj.org/article/912c18f13da748a3b8549d6bb3070e6e
Autor:
Candice, Johnson, Lennart T, Anger, Romualdo, Benigni, David, Bower, Frank, Bringezu, Kevin M, Crofton, Mark T D, Cronin, Kevin P, Cross, Magdalena, Dettwiler, Markus, Frericks, Fjodor, Melnikov, Scott, Miller, David W, Roberts, Diana, Suarez-Rodriguez, Alessandra, Roncaglioni, Elena, Lo Piparo, Raymond R, Tice, Craig, Zwickl, Glenn J, Myatt
Publikováno v:
Comput Toxicol
Understanding the reliability and relevance of a toxicological assessment is important for gauging the overall confidence and communicating the degree of uncertainty related to it. The process involved in assessing reliability and relevance is well d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c0d7cdba4ae97555f59d6dc5262e2a5
https://pubmed.ncbi.nlm.nih.gov/35368849
https://pubmed.ncbi.nlm.nih.gov/35368849
Autor:
Fjodor Melnikov, Chunze Li, Whitney P. Kirschbrown, Tong Lu, Jin Y. Jin, Eleonora Restuccia, Tanja Badovinac Crnjevic, Z. Machackova, Sandhya Girish, Stephanie N. Liu
Publikováno v:
Journal of Clinical Pharmacology
PERJETA (pertuzumab), administered with Herceptin (trastuzumab), is used in the treatment of human epidermal growth factor receptor 2‐positive breast cancer. Pertuzumab is currently approved with an initial loading dose of 840 mg, followed by a 420
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c6c91f2d7951cfbaff947505566724
http://europepmc.org/articles/PMC8361934
http://europepmc.org/articles/PMC8361934
Autor:
Richard M. LoPachin, Phillip Coish, Fjodor Melnikov, David W. Herr, Terrence Gavin, Brian C. Geohagen, Paul T. Anastas
Publikováno v:
Neurotoxicology
Xenobiotic electrophiles can form covalent adducts that may impair protein function, damage DNA, and may lead a range of adverse effects. Cumulative neurotoxicity is one adverse effect that has been linked to covalent protein binding as a Molecular I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e630694350162c53c523a2bb3ce616
https://doi.org/10.1016/j.neuro.2020.04.009
https://doi.org/10.1016/j.neuro.2020.04.009
Autor:
Gavin N. Saari, Terrance J. Kavanagh, Eva Y. Ma, Richard Ramsden, Fjodor Melnikov, Margaret G. Mills, Lauren A. Kristofco, Philip Coish, Bryan W. Brooks, Jakub Kostal, Paul T. Anastas, Julie B. Zimmerman, W. Baylor Steele, Evan P. Gallagher, Adelina Voutchkova-Kostal, Jone Corrales
Publikováno v:
Chem Res Toxicol
The transcription factor Nrf2a induces a cellular antioxidant response and provides protection against chemical-induced oxidative stress, as well as playing a critical role in development and disease. Zebrafish are a powerful model to study the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbcb837f0cf57b9a4bb0be25712ecf2
https://doi.org/10.1021/acs.chemrestox.9b00346
https://doi.org/10.1021/acs.chemrestox.9b00346
Autor:
Jone Corrales, W. Baylor Steele, Lauren A. Kristofco, Terrance J. Kavanagh, Fjodor Melnikov, Margaret G. Mills, Adelina Voutchkova-Kostal, Evan P. Gallagher, Jakub Kostal, Julie B. Zimmerman, Paul T. Anastas, Bridgett N. Hill, Eric J. Corcoran, Bryan W. Brooks, Gavin N. Saari
Publikováno v:
Chemical Research in Toxicology. 33:367-380
Sustainable molecular design of less hazardous chemicals promises to reduce risks to public health and the environment. Computational chemistry modeling coupled with alternative toxicology models (e.g., larval fish) present unique high-throughput opp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25cc6b1ce047a290ca15611c96d89f8d
https://doi.org/10.1021/acs.chemrestox.9b00290
https://doi.org/10.1021/acs.chemrestox.9b00290
Autor:
Granit Molliqaj, Kishan Patel, Michael Robinson, Aria Nouri, Joseph S. Cheng, Fjodor Melnikov, Enrico Tessitore, Shreyas Panchagnula, Luis Kolb, Joaquin Camara-Quintana, Karl Lothard Schaller, Justin Virojanapa, Khalid M. Abbed, Samuel Sommaruga, Xin Sun
Publikováno v:
Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 10, Iss 3076, p 3076 (2021)
Volume 10
Issue 14
Journal of Clinical Medicine, Vol. 10, No 14 (2021) P. 3076
Journal of Clinical Medicine, Vol 10, Iss 3076, p 3076 (2021)
Volume 10
Issue 14
Journal of Clinical Medicine, Vol. 10, No 14 (2021) P. 3076
Stand-alone (SA) zero-profile implants are an alternative to cervical plating (CP) in anterior cervical discectomy and fusion (ACDF). In this study, we investigate differences in surgical outcomes between SA and CP in ACDF. We conducted a retrospecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132040c0604fe2aa9944f0b030870e7b
https://pubmed.ncbi.nlm.nih.gov/34300241
https://pubmed.ncbi.nlm.nih.gov/34300241
Publikováno v:
ACS Sustain Chem Eng
Ratiometric β-lactamase (BLA) reporters are widely used to study transcriptional responses in a high-throughput screening (HTS) format. Typically, a ratio readout (background/target fluorescence) is used for toxicity assessment and structure-activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac7ee740dac960ef5faac9438d02123
https://pubmed.ncbi.nlm.nih.gov/32461840
https://pubmed.ncbi.nlm.nih.gov/32461840
Autor:
W Baylor, Steele, Lauren A, Kristofco, Jone, Corrales, Gavin N, Saari, Eric J, Corcoran, Bridgett N, Hill, Margaret G, Mills, Evan, Gallagher, Terrance J, Kavanagh, Fjodor, Melnikov, Julie B, Zimmerman, Adelina, Voutchkova-Kostal, Paul T, Anastas, Jakub, Kostal, Bryan W, Brooks
Publikováno v:
Chemical research in toxicology. 33(2)
Sustainable molecular design of less hazardous chemicals promises to reduce risks to public health and the environment. Computational chemistry modeling coupled with alternative toxicology models (e.g., larval fish) present unique high-throughput opp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9465d96d8dacf6f96a55cbcbf6849e7
https://pubmed.ncbi.nlm.nih.gov/31789507
https://pubmed.ncbi.nlm.nih.gov/31789507