Effects of a peripherally acting µ-opioid receptor antagonist for the prevention of recurrent acute pancreatitis: study protocol for an investigator-initiated, randomized, placebo-controlled, double-blind clinical trial (PAMORA-RAP trial).

Autor: Cook ME; Department of Gastroenterology and Hepatology, Centre for Pancreatic Diseases and Mech-Sense, Aalborg University Hospital, Aalborg, Denmark. m.cook@rn.dk.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. m.cook@rn.dk., Knoph CS; Department of Gastroenterology and Hepatology, Centre for Pancreatic Diseases and Mech-Sense, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Fjelsted CA; Department of Gastroenterology and Hepatology, Centre for Pancreatic Diseases and Mech-Sense, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Frøkjær JB; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.; Department of Radiology, Aalborg University Hospital, Aalborg, Denmark., Bilgrau AE; Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark., Novovic S; Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Jørgensen MT; Department of Surgery, Odense Pancreas Centre (OPAC), HPB Section, Odense University Hospital, Odense, Denmark., Mortensen MB; Department of Surgery, Odense Pancreas Centre (OPAC), HPB Section, Odense University Hospital, Odense, Denmark., Nielsen LBJ; Digestive Disease Centre K, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark., Hadi A; Digestive Disease Centre K, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark., Berner-Hansen M; Digestive Disease Centre K, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark., Rutkowski W; Department for Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden., Vujasinovic M; Department for Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden., Löhr M; Department for Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden., Drewes AM; Department of Gastroenterology and Hepatology, Centre for Pancreatic Diseases and Mech-Sense, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Olesen SS; Department of Gastroenterology and Hepatology, Centre for Pancreatic Diseases and Mech-Sense, Aalborg University Hospital, Aalborg, Denmark. soso@rn.dk.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. soso@rn.dk.

Publikováno v: Trials [Trials] 2023 May 01; Vol. 24 (1), pp. 301. Date of Electronic Publication: 2023 May 01.

Simple Quantitative Sensory Testing Reveals Paradoxical Co-existence of Hypoesthesia and Hyperalgesia in Diabetes.

Autor: Hansen LEM; Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Centre for Clinical Research, North Denmark Regional Hospital, Hjoerring, Denmark., Fjelsted CA; Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Clinical Institute, Aalborg University, Aalborg, Denmark., Olesen SS; Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Clinical Institute, Aalborg University, Aalborg, Denmark.; Centre of Pancreatic Diseases, Aalborg University Hospital, Aalborg, Denmark., Phillips AE; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Faghih M; Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, United States., Wegeberg AM; Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark., Drewes AM; Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Clinical Institute, Aalborg University, Aalborg, Denmark.; Centre of Pancreatic Diseases, Aalborg University Hospital, Aalborg, Denmark.; Steno Diabetes Center Nordjylland, Aalborg, Denmark., Brock C; Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Clinical Institute, Aalborg University, Aalborg, Denmark.; Steno Diabetes Center Nordjylland, Aalborg, Denmark.

Publikováno v: Frontiers in pain research (Lausanne, Switzerland) [Front Pain Res (Lausanne)] 2021 Jun 28; Vol. 2, pp. 701172. Date of Electronic Publication: 2021 Jun 28 (Print Publication: 2021).

Opioid analgesia and severity of acute pancreatitis: An international multicentre cohort study on pain management in acute pancreatitis.

Autor: Pandanaboyana S; HPB and Transplant Unit, Freeman Hospital, Newcastle Upon Tyne, UK.; Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Knoph CS; Centre for Pancreatic Diseases, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Olesen SS; Centre for Pancreatic Diseases, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Jones M; HPB and Transplant Unit, Freeman Hospital, Newcastle Upon Tyne, UK., Lucocq J; Department of HPB Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK., Samanta J; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India., Talukdar R; Asian Institute of Gastroenterology, Hyderabad, India., Capurso G; Pancreatico-Biliary Endoscopy Division, Vita-Salute San Raffaele University, Milan, Italy., de-Madaria E; Gastroenterology Department, Dr. Balmis General University Hospital, Alicante, Spain., Yadav D; Division of Gastroenterology & Hepatology, University of Pittsburgh Medical Centre, Pittsburgh, Pennsylvania, USA., Siriwardena AK; HBP Unit, Manchester Royal Infirmary, Manchester, UK., Windsor J; Surgical and Translational Research Centre, University of Auckland, Auckland, New Zealand., Drewes AM; Centre for Pancreatic Diseases, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Nayar M; HPB and Transplant Unit, Freeman Hospital, Newcastle Upon Tyne, UK.; Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.

Publikováno v: United European gastroenterology journal [United European Gastroenterol J] 2024 Apr; Vol. 12 (3), pp. 326-338. Date of Electronic Publication: 2024 Mar 04.

Exploring the value of early laboratory indicators combined with pancreatitis activity scoring system in assessing the severity and prognosis of acute pancreatitis.

Autor: Fang Xu¹, Xin Hu² huxin0027@163.com, Shu-ling Li³

Publikováno v: Pakistan Journal of Medical Sciences. Sep/Oct2023, Vol. 39 Issue 5, p1462-1467. 6p.

No Effect of Methylnaltrexone on Acute Pancreatitis Severity: A Multicenter Randomized Controlled Trial.

Autor: Knoph CS; Mech-Sense and Centre for Pancreatic Diseases, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Cook ME; Mech-Sense and Centre for Pancreatic Diseases, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Novovic S; Pancreatitis Centre East, Gastro Unit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Hansen MB; Digestive Disease Centre K, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark., Mortensen MB; Odense Pancreas Centre, HPB Section, Department of Surgery, Odense University Hospital, Odense, Denmark., Nielsen LBJ; Digestive Disease Centre K, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark., Høgsberg IM; Odense Pancreas Centre, HPB Section, Department of Surgery, Odense University Hospital, Odense, Denmark., Salomon C; Department of Surgery A4, Odense University Hospital, Svendborg, Denmark., Neergaard CEL; Odense Pancreas Centre, HPB Section, Department of Surgery, Odense University Hospital, Odense, Denmark., Aajwad AJ; Department of Surgery A4, Odense University Hospital, Svendborg, Denmark., Pandanaboyana S; HPB and Transplant Unit, Freeman Hospital, Newcastle upon Tyne, UK., Sørensen LS; Department of Gastrointestinal Surgery A, Aalborg Hospital, Aalborg, Denmark., Thorlacius-Ussing O; Department of Gastrointestinal Surgery A, Aalborg Hospital, Aalborg, Denmark., Frøkjær JB; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.; Mech-Sense, Department of Radiology, Aalborg University Hospital, Aalborg, Denmark., Olesen SS; Mech-Sense and Centre for Pancreatic Diseases, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Drewes AM; Mech-Sense and Centre for Pancreatic Diseases, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Publikováno v: The American journal of gastroenterology [Am J Gastroenterol] 2024 Nov 01; Vol. 119 (11), pp. 2307-2316. Date of Electronic Publication: 2024 Jun 25.