Výsledky vyhledávání - "Fixemer, Sonja"

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Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies.

Autor: Fixemer, Sonja^1,2 (AUTHOR), Ameli, Corrado¹ (AUTHOR), Hammer, Gaël^2,3 (AUTHOR), Salamanca, Luis^1,4 (AUTHOR), Uriarte Huarte, Oihane^1,2 (AUTHOR), Schwartz, Chantal³ (AUTHOR), Gérardy, Jean-Jacques^2,3 (AUTHOR), Mechawar, Naguib⁵ (AUTHOR), Skupin, Alexander¹ (AUTHOR), Mittelbronn, Michel^1,2,3,6,7,8 (AUTHOR), Bouvier, David S.^1,2,3 (AUTHOR) David.Bouvier@lns.etat.lu

Publikováno v: Acta Neuropathologica Communications. 3/16/2022, Vol. 10 Issue 1, p1-20. 20p.

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Additional file 2 of Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-�� and ��-synuclein pathologies in the hippocampus of patients with Alzheimer��s disease and dementia with Lewy bodies

Autor: Fixemer, Sonja, Ameli, Corrado, Hammer, Ga��l, Salamanca, Luis, Uriarte Huarte, Oihane, Schwartz, Chantal, G��rardy, Jean-Jacques, Mechawar, Naguib, Skupin, Alexander, Mittelbronn, Michel, Bouvier, David S.

Additional file 2: Fig. S2. Iba1 density in hippocampal subfields of AD and DLB do not differ from age-matched CTLs. Iba1 volume (%) across conditions and hippocampal subfields

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a6816a4641740a2447028f3bda1fff

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3D Modelling of a Spatially Resolved Energy Metabolism in Physiological Astrocytic Morphology

Autor: Farina, Sofia, Voorsluijs, Valerie, Fixemer, Sonja, Bouvier, David, Claus, Susanne, Bordas, Stéphane, Skupin, Alexander

Astrocytes, the most abundant cell in the central nervous system, have a star-shaped morphology and play a central role in brain homeostasis as metabolic mediators between neurons and blood vessels. Recent evidence put astrocytes therefore in the foc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2658::542faad2cd8b0855773a5651fa23d288
http://orbilu.uni.lu/handle/10993/54826

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Additional file 6 of Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-�� and ��-synuclein pathologies in the hippocampus of patients with Alzheimer��s disease and dementia with Lewy bodies

Additional file 6: Fig. S6. Confocal stainings of pTau, A�� and pSyn across conditions and hippocampal subfields. 80��100 ��m thick hippocampal sections were immunostained with the AT8 antibody against pTau (Ser202, Thr205) (cyan), the

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Additional file 5 of Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-�� and ��-synuclein pathologies in the hippocampus of patients with Alzheimer��s disease and dementia with Lewy bodies

Additional file 5: Fig. S5. Validation of A�� and pTau stainings on FFPE samples of a neuropathologically confirmed DLB case. 3 ��m thick paraffin block sections from the temporal superior median gyrus and frontal median gyrus were obtained f

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Additional file 8 of Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-�� and ��-synuclein pathologies in the hippocampus of patients with Alzheimer��s disease and dementia with Lewy bodies

Additional file 8: Fig. 8. Confocal description of pSyn staining in a neuropathologically confirmed AD case. 80-100 ��m thick sections from fixed hippocampus from a 90-year-old male AD patient (case 28) were immunostained against pSyn (11A5, 81A;

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Additional file 3 of Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-�� and ��-synuclein pathologies in the hippocampus of patients with Alzheimer��s disease and dementia with Lewy bodies

Additional file 3: Fig. S3. List and description of all morphological features with prototypic morphologies for lowest and highest feature values. Scale bars = 20 ��m

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Additional file 1 of Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-�� and ��-synuclein pathologies in the hippocampus of patients with Alzheimer��s disease and dementia with Lewy bodies

Additional file 1: Fig. S1. Hippocampal subfields. Anatomically defined CA1, CA3 and DG/CA4 subfields of the hippocampus for pTau, A��, pSyn and Iba1 z-stack acquisitions. Hippocampal section of an 83-year-old female AD patient (case 24) with A�

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