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The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells.

Autor: Trsan T; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Peng V; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Krishna C; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ohara TE; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Beatty WL; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Sudan R; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Kanai M; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Krishnamoorthy P; Washington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA., Rodrigues PF; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Fachi JL; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Grajales-Reyes G; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Jaeger N; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Fitzpatrick JAJ; Washington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA; Departments of Cell Biology & Physiology and Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110, USA., Cella M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Gilfillan S; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Nakata T; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jaiswal A; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Stappenbeck TS; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA., Daly MJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Xavier RJ; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: xavier@molbio.mgh.harvard.edu., Colonna M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: mcolonna@wustl.edu.

Publikováno v: Developmental cell [Dev Cell] 2024 Sep 23; Vol. 59 (18), pp. 2460-2476.e10. Date of Electronic Publication: 2024 Jun 27.

Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming.

Autor: Sun Z; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA., Kwon JS; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Program in Computational and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA., Ren Y; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Program in Developmental, Regenerative, and Stem Cell Biology, Washington University School of Medicine, St. Louis, MO 63110, USA., Chen S; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA., Walker CK; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA., Lu X; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA., Cates K; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Program in Molecular Genetics and Genomics, Washington University School of Medicine, St. Louis, MO 63110, USA., Karahan H; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Sviben S; Washington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA., Fitzpatrick JAJ; Washington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA., Valdez C; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX 75390, USA., Houlden H; UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK., Karch CM; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Bateman RJ; Tracy Family SILQ Center for Neurodegenerative Biology, St. Louis, MO 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Sato C; Tracy Family SILQ Center for Neurodegenerative Biology, St. Louis, MO 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Mennerick SJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA., Diamond MI; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX 75390, USA., Kim J; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Tanzi RE; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Holtzman DM; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Yoo AS; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Aug 02; Vol. 385 (6708), pp. adl2992. Date of Electronic Publication: 2024 Aug 02.