Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump

Autor: Fitzpatrick, AWP, Llabrés, S, Neuberger, A, Blaza, JN, Bai, X-C, Okada, U, Murakami, S, Van Veen, HW, Zachariae, U, Scheres, SHW, Luisi, BF, Du, D

The MacA-MacB-TolC assembly of Escherichia coli is a transmembrane machine that spans the cell envelope and actively extrudes substrates, including macrolide antibiotics and polypeptide virulence factors. These transport processes are energized by th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7bf00ff2c3d71c5bee665b9a7f56ce
https://www.repository.cam.ac.uk/handle/1810/266255

Structures of LRP2 reveal a molecular machine for endocytosis.

Autor: Beenken A; Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Cerutti G; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Brasch J; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Guo Y; Aaron Diamond AIDS Research Center, Columbia University, New York, NY 10032, USA., Sheng Z; Aaron Diamond AIDS Research Center, Columbia University, New York, NY 10032, USA., Erdjument-Bromage H; Department of Cell Biology, New York University Grossman School of Medicine, New York, NY 10016, USA., Aziz Z; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Robbins-Juarez SY; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Chavez EY; Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA., Ahlsen G; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Katsamba PS; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Neubert TA; Department of Cell Biology, New York University Grossman School of Medicine, New York, NY 10016, USA., Fitzpatrick AWP; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: anthony.fitzpatrick@columbia.edu., Barasch J; Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Columbia University George M. O'Brien Urology Center, New York, NY 10032, USA. Electronic address: jmb4@columbia.edu., Shapiro L; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Aaron Diamond AIDS Research Center, Columbia University, New York, NY 10032, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address: lss8@columbia.edu.

Publikováno v: Cell [Cell] 2023 Feb 16; Vol. 186 (4), pp. 821-836.e13. Date of Electronic Publication: 2023 Feb 06.

Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.

Autor: Chang A; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th Street, New York, NY 10032, USA., Xiang X; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th Street, New York, NY 10032, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA., Wang J; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th Street, New York, NY 10032, USA., Lee C; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th Street, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA., Arakhamia T; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th Street, New York, NY 10032, USA., Simjanoska M; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th Street, New York, NY 10032, USA., Wang C; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA., Carlomagno Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Zhang G; Proteomics and Metabolomics Core Facility, Weill Cornell Medicine, New York, NY 10021, USA., Dhingra S; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Thierry M; Centre for Cognitive Neurology, Department of Neurology, New York University School of Medicine, New York, NY 10016, USA., Perneel J; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Heeman B; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Forgrave LM; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada; Department of Pathology and Laboratory Medicine, St. Paul's Hospital, Providence Health Care, Vancouver, Canada., DeTure M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., DeMarco ML; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada; Department of Pathology and Laboratory Medicine, St. Paul's Hospital, Providence Health Care, Vancouver, Canada., Cook CN; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Rademakers R; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Stowell MHB; Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA. Electronic address: stowellm@colorado.edu., Mackenzie IRA; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada. Electronic address: ian.mackenzie@vch.ca., Fitzpatrick AWP; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th Street, New York, NY 10032, USA. Electronic address: anthony.fitzpatrick@columbia.edu.

Publikováno v: Cell [Cell] 2022 Apr 14; Vol. 185 (8), pp. 1346-1355.e15. Date of Electronic Publication: 2022 Mar 04.

The AD tau core spontaneously self-assembles and recruits full-length tau to filaments.

Autor: Carlomagno Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Manne S; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., DeTure M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Prudencio M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Zhang YJ; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Hanna Al-Shaikh R; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Dunmore JA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Daughrity LM; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Song Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Castanedes-Casey M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Lewis-Tuffin LJ; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA., Nicholson KA; Sean M. Healey and AMG Center for ALS, Massachusetts General Hospital (MGH), Boston, MA, USA., Wszolek ZK; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Fitzpatrick AWP; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA. Electronic address: petrucelli.leonard@mayo.edu., Cook CN; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA. Electronic address: cook.casey@mayo.edu.

Publikováno v: Cell reports [Cell Rep] 2021 Mar 16; Vol. 34 (11), pp. 108843.

Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu.

Autor: Ho CM; The Molecular Biology Institute, University of California, Los Angeles, CA, USA.; Department of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA, USA.; California NanoSystems Institute, University of California, Los Angeles, CA, USA., Li X; California NanoSystems Institute, University of California, Los Angeles, CA, USA.; Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China., Lai M; Department of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA, USA.; California NanoSystems Institute, University of California, Los Angeles, CA, USA., Terwilliger TC; Los Alamos National Laboratory and the New Mexico Consortium, Los Alamos, NM, USA., Beck JR; Departments of Medicine and Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Wohlschlegel J; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Goldberg DE; Departments of Medicine and Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Fitzpatrick AWP; Zuckerman Institute, Columbia Medical School, New York, NY, USA., Zhou ZH; The Molecular Biology Institute, University of California, Los Angeles, CA, USA. Hong.Zhou@UCLA.edu.; Department of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA, USA. Hong.Zhou@UCLA.edu.; California NanoSystems Institute, University of California, Los Angeles, CA, USA. Hong.Zhou@UCLA.edu.

Publikováno v: Nature methods [Nat Methods] 2020 Jan; Vol. 17 (1), pp. 79-85. Date of Electronic Publication: 2019 Nov 25.