Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation

Autor: Sherwood, John L., Amici, Mascia, Dargan, Sheila L., Culley, Georgia R., Fitzjohn, Stephen M., Jane, David E., Collingridge, Graham L., Lodge, David, Bortolotto, Zuner A.

Publikováno v: In Neurochemistry International September 2012 61(4):482-489

Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs

Autor: Sanderson Thomas M, Collingridge Graham L, Fitzjohn Stephen M

Publikováno v: Molecular Brain, Vol 4, Iss 1, p 30 (2011)

Abstract The removal of AMPA receptors from synapses is a major component of long-term depression (LTD). How this occurs, however, is still only partially understood. To investigate the trafficking of AMPA receptors in real-time we previously tagged

Externí odkaz: https://doaj.org/article/2393e7c6c0c84f9fad6fe3265b4fa8be

A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases

Autor: Peineau Stéphane, Nicolas Céline S, Bortolotto Zuner A, Bhat Ratan V, Ryves W Jonathan, Harwood Adrian J, Dournaud Pascal, Fitzjohn Stephen M, Collingridge Graham L

Publikováno v: Molecular Brain, Vol 2, Iss 1, p 22 (2009)

Abstract Background The signalling mechanisms involved in the induction of N-methyl-D-aspartate (NMDA) receptor-dependent long-term depression (LTD) in the hippocampus are poorly understood. Numerous studies have presented evidence both for and again

Externí odkaz: https://doaj.org/article/310c77670c7a41d488343ea4f70c571d

Forebrain-selective AMPA-receptor antagonism guided by TARPλ 3-8 as an antiepileptic mechanism

Autor: Kato, Akihiko S., Burris, Kevin D., Gardinier, Kevin M., Gernert, Douglas L., Porter, Warren J., Reel, Jon, Ding, Chunjin, Tu, Yuan, Schober, Douglas A., Lee, Matthew R., Heinz, Beverly A., Fitch, Thomas E., Gleason, Scott D., Catlow, John T., Yu, Hong, Fitzjohn, Stephen M., Pasqui, Francesca, Wang, He, Qian, Yuewei, Sher, Emanuele, Zwart, Ruud, Wafford, Keith A., Rasmussen, Kurt, Ornstein, Paul L., Isaac, John T.R., Nisenbaum, Eric S., Bredt, David S., Witkin, Jeffrey M.

Publikováno v: Kato, A S, Burris, K D, Gardinier, K M, Gernert, D L, Porter, W J, Reel, J, Ding, C, Tu, Y, Schober, D A, Lee, M R, Heinz, B A, Fitch, T E, Gleason, S D, Catlow, J T, Yu, H, Fitzjohn, S M, Pasqui, F, Wang, H, Qian, Y, Sher, E, Zwart, R, Wafford, K A, Rasmussen, K, Ornstein, P L, Isaac, J T R, Nisenbaum, E S, Bredt, D S & Witkin, J M 2016, ' Forebrain-selective AMPA-receptor antagonism guided by TARPλ 3-8 as an antiepileptic mechanism ', Nature Medicine, vol. 22, no. 12, pp. 1496-1501 . https://doi.org/10.1038/nm.4221

Pharmacological manipulation of specific neural circuits to optimize therapeutic index is an unrealized goal in neurology and psychiatry. AMPA receptors are important for excitatory synaptic transmission, and their antagonists are antiepileptic. Alth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2642::7bc7ef35de0cdc494d2e07d26fc9f1f8
https://research-information.bris.ac.uk/en/publications/2a72c95c-feee-43b2-8322-d4ed72a55710

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.