Zobrazeno 1 - 10
of 407
pro vyhledávání: '"Fitzgerald RC"'
Autor:
Ghimire, B, Landy, R, Maroni, R, Smith, SG, Debiram-Beecham, I, Sasieni, PD, Fitzgerald, RC, Rubin, G, Walter, FM, Waller, J, Attwood, S, Parmar, M, Delaney, B, de Caestecker, J, Atkin, W, Hackshaw, A, van Heyningen, C, Underwood, T, Stella, A, Saxby, C, Lorincz, A, Turnbull, N, Doorbar, J, Mannion-Krase, G, Kaimi, I, Kasanicki, M, Kelleher, S, Stockley, L, Assari, T, Kadyan, S, Hollamby, V, Edwards, K, MacDonald, H, Shaw, V, Leishman, H, Roper, H, McCloskey, K, Jung, H, Phillips, A, Masjak-Newman, G, Fell, K, Collins, H, Zolle, O, McGlone, P, Crabb, T, Merrin, L, Cross, M, Jones, A, Simpson, T, Murray, E, Perugia, A, Thompson, M, Dumbleton, J, Morar, M, Frowd, N, Hardcastle, A, Carmichael, D, Maxton, F, Farnworth, F, Baddeley, E, Offman, J
Availability of data and materials: The trial protocol, statistical analysis plan, and statistical report are available via the University of Cambridge data repository (https://www.data.cam.ac.uk/repository). Datasets will be available from R Fitzger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______900::9405253884bc1fbfa4725a92da6c3a96
https://bura.brunel.ac.uk/handle/2438/26156
https://bura.brunel.ac.uk/handle/2438/26156
Autor:
Katz-Summercorn, AC, Jammula, S, Frangou, A, Peneva, I, O'Donovan, M, Tripathi, M, Malhotra, S, Di Pietro, M, Abbas, S, Devonshire, G, Januszewicz, W, Blasko, A, Nowicki-Osuch, K, MacRae, S, Northrop, A, Redmond, AM, Wedge, DC, Fitzgerald, RC
Publikováno v:
Nature Communications. 13
Barrett’s esophagus is a pre-malignant lesion that can progress to esophageal adenocarcinoma. We perform a multi-omic analysis of pre-cancer samples from 146 patients with a range of outcomes, comprising 642 person years of follow-up. Whole genome
Autor:
Bornschein, J, Wernisch, L, Secrier, M, Miremadi, A, Perner, J, MacRae, S, O'Donovan, M, Newton, R, Menon, S, Bower, L, Eldridge, MD, Devonshire, G, Cheah, C, Turkington, R, Hardwick, RH, Selgrad, M, Venerito, M, Malfertheiner, P, Fitzgerald, RC, Noorani, A, Elliott, RF, Edwards, PAW, Grehan, N, Nutzinger, B, Crawte, J, Chettouh, H, Contino, G, Li, X, Gregson, E, Zeki, S, De la Rue, R, Malhotra, S, Tavare, S, Lynch, AG, Smith, ML, Davies, J, Crichton, C, Carroll, N, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, O'Neill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Underwood, TJ, Noble, F, Owsley, J, Barr, H, Shepherd, N, Old, O, Lagergren, J, Gossage, J, Davies, A, Chang, F, Zylstra, J, Goh, V, Ciccarelli, FD, Sanders, G, Berrisford, R, Harden, C, Bunting, D, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Eneh, V, Igali, L, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Hanna, GB, Peters, CJ, Grabowska, A
Publikováno v:
on behalf of the OCCAMS Consortium 2019, ' Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction ', International Journal of Cancer . https://doi.org/10.1002/ijc.32384
International Journal of Cancer
International Journal of Cancer
Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often difficult to decipher. We hypothesized that the transcriptomic profile might reveal molecular subgroups which could help to
Association Between Levels of Hormones and Risk of Esophageal Adenocarcinoma and Barrett's Esophagus
Autor:
Xie, S-H, Fang, R, Huang, M, Dai, J, Thrift, AP, Anderson, LA, Chow, W-H, Bernstein, L, Gammon, MD, Risch, HA, Shaheen, NJ, Reid, BJ, Wu, AH, Iyer, PG, Liu, G, Corley, DA, Whiteman, DC, Caldas, C, Pharoah, PD, Hardie, LJ, Fitzgerald, RC, Shen, H, Vaughan, TL, Lagergren, J
Background & Aims Esophageal adenocarcinoma (EAC) occurs most frequently in men. We performed a Mendelian randomization analysis to investigate whether genetic factors that regulate levels of sex hormones associated with risk of EAC or Barrett’s es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::baf54fb634b810b9355a149aad8b550b
Autor:
Rahman, SA, Walker, RC, Lloyd, MA, Grace, BL, Van Boxel, GI, Kingma, BF, Ruurda, JP, Van Hillegersberg, R, Harris, S, Parsons, S, Mercer, S, Griffiths, EA, O'Neill, Turkington, R, Fitzgerald, RC, Underwood, TJ, OCCAMS Consortium
BACKGROUND: Early cancer recurrence after oesophagectomy is a common problem, with an incidence of 20-30 per cent despite the widespread use of neoadjuvant treatment. Quantification of this risk is difficult and existing models perform poorly. This s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34dab7a6aa5f4c1b5ec95e1bd7de3b07
Autor:
Mourikis, TP, Benedetti, L, Foxall, E, Temelkovski, D, Nulsen, J, Perner, J, Cereda, M, Lagergren, J, Howell, M, Yau, C, Fitzgerald, RC, Scaffidi, P, Noorani, A, Edwards, PAW, Elliott, RF, Grehan, N, Nutzinger, B, Hughes, C, Fidziukiewicz, E, Bornschein, J, MacRae, S, Crawte, J, Northrop, A, Contino, G, Li, X, De la Rue, R, Katz-Summercorn, A, Abbas, S, Loureda, D, O'Donovan, M, Miremadi, A, Malhotra, S, Tripathi, M, Tavare, S, Lynch, AG, Eldridge, M, Secrier, M, Bower, L, Devonshire, G, Jammula, S, Davies, J, Crichton, C, Carroll, N, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Sharrocks, A, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, O'Neill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Underwood, TJ, Walker, RC, Grace, BL, Barr, H, Shepherd, N, Old, O, Gossage, J, Davies, A, Chang, F, Zylstra, J, Mahadeva, U, Goh, V, Sanders, G, Berrisford, R, Harden, C, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Igali, L, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Hanna, GB, Peters, CJ, Moorthy, K, Grabowska, A, Turkington, R, McManus, D, Khoo, D, Fickling, W, Ciccarelli, FD
The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning algorithm to identify cancer genes in in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::56bbcb4834a826025994807c5a97eb9d
https://www.repository.cam.ac.uk/handle/1810/307928
https://www.repository.cam.ac.uk/handle/1810/307928
Autor:
Fitzgerald, RC
BACKGROUND AND AIMS Diagnosis and surveillance of Barrett’s esophagus (BE) and eosinophilic esophagitis (EoE) have become emerging public health issues. Cytosponge® is a novel, minimally invasive esophageal cell collection device. We aimed to asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee54b23bbce95289f8864ac354c7dca
Autor:
Offman, J, Muldrew, B, O'Donovan, M, Debiram-Beecham, I, Pesola, F, Kaimi, I, Smith, SG, Wilson, A, Khan, Z, Lao-Sirieix, P, Aigret, B, Walter, FM, Rubin, G, Morris, S, Jackson, C, Sasieni, P, Fitzgerald, RC, BEST3 Trial team
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
Background: Early detection of oesophageal cancer improves outcomes; however, the optimal strategy for identifying patients at increased risk from the pre-cancerous lesion Barrett’s oesophagus (BE) is not clear. The Cytosponge, a novel non-endoscop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2ba16987a53a862d49fd59774ca778
Autor:
Frankell, AM, Jammula, S, Li, X, Contino, G, Killcoyne, S, Abbas, S, Perner, J, Bower, L, Devonshire, G, Cocks, E, Grehan, N, Mok, J, O'Donovan, M, MacRae, S, Eldridge, MD, Tavare, S, Fitzgerald, RC, Noorani, A, Edwards, PAW, Grehanl, N, Nutzinger, B, Hughes, CI, Fidziukiewicz, E, Northrop, A, De la Rue, R, Katz-Summercorn, A, Loureda, D, Miremadi, A, Malhotra, S, Tripathi, M, Lynch, AG, Eldridge, M, Secrier, M, Davies, J, Crichton, C, Carro, N, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Sharrocks, A, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, ONeill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Underwood, T, Walker, RC, Grace, BL, Barr, H, Shepherd, N, Old, O, Lagergren, J, Gossage, J, Davies, A, Chang, F, Zylstra, J, Mahadeva, U, Goh, V, Ciccarelli, FD, Sanders, G, Berrisford, R, Harden, C, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Igali, L, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Hanna, GB, Moorthy, K, Peters, CJ, Grabowska, A, Turkington, R, McManus, D, Coleman, H, Khoo, D, Fickling, W
Publikováno v:
Nature genetics
Esophageal Adenocarcinoma (EAC) is a poor prognosis cancer type with rapidly rising incidence. Our understanding of genetic events which drive EAC development is limited and there are few molecular biomarkers for prognostication or therapeutics. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99929338d90f78f1c05cc30099825dcb
https://doi.org/10.1101/310029
https://doi.org/10.1101/310029
Autor:
Dong, J, Levine, DM, Buas, MF, Zhang, R, Onstad, L, Fitzgerald, RC, Stomach and Oesophageal Cancer Study (SOCS) Consortium, Corley, DA, Shaheen, NJ, Lagergren, J, Hardie, LJ, Reid, BJ, Iyer, PG, Risch, HA, Caldas, C, Caldas, I, Pharoah, PD, Liu, G, Gammon, MD, Chow, W-H, Bernstein, L, Bird, NC, Ye, W, Wu, AH, Anderson, LA, MacGregor, S, Whiteman, DC, Vaughan, TL, Thrift, AP
Publikováno v:
Dong, J, Levine, D, Buas, M, Zhang, R, Onstad, L, Fitzgerald, R C, consortium, S A O C S, Corley, D A, Shaheen, N J, Lagergren, J, Hardie, L J, Reid, B J, Iyer, P G, Risch, H A, Caldas, C, Caldas, I, Pharoah, P D, Liu, G, Gammon, M D, Chow, W-H, Bernstein, L, Bird, N C, Ye, W, Wu, A H, Anderson, L A, Macgregor, S, Whiteman, D C, Vaughan, T L & Thrift, A 2018, ' Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus ', Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association . https://doi.org/10.1016/j.cgh.2018.03.007
Background & Aims: Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for esophageal adenocarcinoma (EA) and Barrett’s esophagus (BE). However, variants in these loci account for a small fraction of cases of EA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::447fd3561641347d5c536d75bbaee328
https://pure.qub.ac.uk/en/publications/2a42322e-0183-4f59-9170-608e0e4fa6bb
https://pure.qub.ac.uk/en/publications/2a42322e-0183-4f59-9170-608e0e4fa6bb