Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Fitnat H. Yildiz"'
Autor:
Anna Potapova, William Garvey, Peter Dahl, Shuaiqi Guo, Yunjie Chang, Carmen Schwechheimer, Michael A. Trebino, Kyle A. Floyd, Brett S. Phinney, Jun Liu, Nikhil S. Malvankar, Fitnat H. Yildiz
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Biofilms are matrix-encased microbial communities that increase the environmental fitness and infectivity of many human pathogens including Vibrio cholerae. Biofilm matrix assembly is essential for biofilm formation and function. Known compo
Externí odkaz:
https://doaj.org/article/90ccdbc693ef447e9729b2cff902d02c
Autor:
Giordan Kitts, Andrew Rogers, Jennifer K Teschler, Jin Hwan Park, Michael A Trebino, Issac Chaudry, Ivan Erill, Fitnat H Yildiz
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011415 (2023)
The facultative human pathogen, Vibrio cholerae, employs two-component signal transduction systems (TCS) to sense and respond to environmental signals encountered during its infection cycle. TCSs consist of a sensor histidine kinase (HK) and a respon
Externí odkaz:
https://doaj.org/article/41eaaa7349374d8593b949e137d6ff8d
Autor:
Jennifer K. Teschler, Eva Jiménez-Siebert, Hannah Jeckel, Praveen K. Singh, Jin Hwan Park, Stefan Pukatzki, Carey D. Nadell, Knut Drescher, Fitnat H. Yildiz
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The human pathogen Vibrio cholerae grows as biofilms, communities of cells encased in an extracellular matrix. When growing in biofilms, cells compete for resources and space. One common competitive mechanism among Gram-negative bacteria is
Externí odkaz:
https://doaj.org/article/964f624d3b414a30862f81f9ffbffbd6
Autor:
Kyle A. Floyd, Calvin K. Lee, Wujing Xian, Mahmoud Nametalla, Aneesa Valentine, Benjamin Crair, Shiwei Zhu, Hannah Q. Hughes, Jennifer L. Chlebek, Daniel C. Wu, Jin Hwan Park, Ali M. Farhat, Charles J. Lomba, Courtney K. Ellison, Yves V. Brun, Javier Campos-Gomez, Ankur B. Dalia, Jun Liu, Nicolas Biais, Gerard C. L. Wong, Fitnat H. Yildiz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Biofilm formation by Vibrio cholerae is regulated by c-di-GMP and requires the type IV MSHA pilus. Here, Floyd et al. show that the MSHA pilus is a dynamic system, and that both extension and retraction are directly controlled by c-di-GMP via regulat
Externí odkaz:
https://doaj.org/article/cabf8badabb34c2f9c45f7702f8ed372
Autor:
Carmen Schwechheimer, Kassidy Hebert, Sarvind Tripathi, Praveen K Singh, Kyle A Floyd, Elise R Brown, Monique E Porcella, Jacqueline Osorio, Joseph T M Kiblen, Fernando A Pagliai, Knut Drescher, Seth M Rubin, Fitnat H Yildiz
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008745 (2020)
Production of an extracellular matrix is essential for biofilm formation, as this matrix both secures and protects the cells it encases. Mechanisms underlying production and assembly of matrices are poorly understood. Vibrio cholerae, relies heavily
Externí odkaz:
https://doaj.org/article/cf898045b4b347c9906856ac86023e93
Autor:
Avatar Joshi, Samar A Mahmoud, Soo-Kyoung Kim, Justyne L Ogdahl, Vincent T Lee, Peter Chien, Fitnat H Yildiz
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008897 (2020)
The LonA (or Lon) protease is a central post-translational regulator in diverse bacterial species. In Vibrio cholerae, LonA regulates a broad range of behaviors including cell division, biofilm formation, flagellar motility, c-di-GMP levels, the type
Externí odkaz:
https://doaj.org/article/0f8213a216e7442db52d0abcc33f8aa9
Autor:
Daniel C Wu, David Zamorano-Sánchez, Fernando A Pagliai, Jin Hwan Park, Kyle A Floyd, Calvin K Lee, Giordan Kitts, Christopher B Rose, Eric M Bilotta, Gerard C L Wong, Fitnat H Yildiz
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008703 (2020)
The assembly status of the V. cholerae flagellum regulates biofilm formation, suggesting that the bacterium senses a lack of movement to commit to a sessile lifestyle. Motility and biofilm formation are inversely regulated by the second messenger mol
Externí odkaz:
https://doaj.org/article/af2ef7142989411ab50faab7a6c582c4
Autor:
Giordan Kitts, Krista M. Giglio, David Zamorano-Sánchez, Jin Hwan Park, Loni Townsley, Richard B. Cooley, Benjamin R. Wucher, Karl E. Klose, Carey D. Nadell, Fitnat H. Yildiz, Holger Sondermann
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT The dinucleotide second messenger c-di-GMP has emerged as a central regulator of reversible cell attachment during bacterial biofilm formation. A prominent cell adhesion mechanism first identified in pseudomonads combines two c-di-GMP-mediat
Externí odkaz:
https://doaj.org/article/9a8a543adaa141dcaa3c9dfe3f2eca0c
Publikováno v:
Molecules, Vol 26, Iss 15, p 4582 (2021)
Biofilms, the predominant growth mode of microorganisms, pose a significant risk to human health. The protective biofilm matrix, typically composed of exopolysaccharides, proteins, nucleic acids, and lipids, combined with biofilm-grown bacteria’s h
Externí odkaz:
https://doaj.org/article/0c3f799a682545b89c7f415a7e10e07f
Autor:
David Zamorano-Sánchez, Wujing Xian, Calvin K. Lee, Mauro Salinas, Wiriya Thongsomboon, Lynette Cegelski, Gerard C. L. Wong, Fitnat H. Yildiz
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT Vibrio cholerae biofilm formation and associated motility suppression are correlated with increased concentrations of cyclic diguanylate monophosphate (c-di-GMP), which are in turn driven by increased levels and/or activity of diguanylate cy
Externí odkaz:
https://doaj.org/article/1799c15680334db5b2cd9be4e80e0196