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Improvement of a synthetic live bacterial therapeutic for phenylketonuria with biosensor-enabled enzyme engineering.

Autor: Adolfsen KJ; Zymergen Inc. (formerly enEvolv Inc.), 100 Acorn Park Drive, Cambridge, MA, 02140, USA., Callihan I; Zymergen Inc. (formerly enEvolv Inc.), 100 Acorn Park Drive, Cambridge, MA, 02140, USA., Monahan CE; Synlogic Inc, 301 Binney St, Cambridge, MA, 02139, USA., Greisen PJ; Zymergen Inc. (formerly enEvolv Inc.), 100 Acorn Park Drive, Cambridge, MA, 02140, USA.; Novo Nordisk Research Center Seattle Inc, 530 Fairview Ave N, Seattle, WA, 98109, USA., Spoonamore J; Zymergen Inc. (formerly enEvolv Inc.), 100 Acorn Park Drive, Cambridge, MA, 02140, USA., Momin M; Synlogic Inc, 301 Binney St, Cambridge, MA, 02139, USA., Fitch LE; Zymergen Inc. (formerly enEvolv Inc.), 100 Acorn Park Drive, Cambridge, MA, 02140, USA., Castillo MJ; Synlogic Inc, 301 Binney St, Cambridge, MA, 02139, USA., Weng L; Zymergen Inc. (formerly enEvolv Inc.), 100 Acorn Park Drive, Cambridge, MA, 02140, USA.; Sana Biotechnology, 1 Tower Place Suite 500, South San Francisco, CA, 94080, USA., Renaud L; Synlogic Inc, 301 Binney St, Cambridge, MA, 02139, USA., Weile CJ; Zymergen Inc. (formerly enEvolv Inc.), 100 Acorn Park Drive, Cambridge, MA, 02140, USA., Konieczka JH; Zymergen Inc. (formerly enEvolv Inc.), 100 Acorn Park Drive, Cambridge, MA, 02140, USA., Mirabella T; Synlogic Inc, 301 Binney St, Cambridge, MA, 02139, USA., Abin-Fuentes A; Synlogic Inc, 301 Binney St, Cambridge, MA, 02139, USA., Lawrence AG; Zymergen Inc. (formerly enEvolv Inc.), 100 Acorn Park Drive, Cambridge, MA, 02140, USA., Isabella VM; Synlogic Inc, 301 Binney St, Cambridge, MA, 02139, USA. vincent@synlogictx.com.

Publikováno v: Nature communications [Nat Commun] 2021 Oct 28; Vol. 12 (1), pp. 6215. Date of Electronic Publication: 2021 Oct 28.