Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Fishwick, CWG"'
Autor:
Orritt, KM, Feng, L, Newell, JF, Sutton, JN, Grossman, S, Germe, T, Abbott, LR, Jackson, HL, Bury, BKL, Maxwell, A, McPhillie, MJ, Fishwick, CWG
By 2050, it is predicted that antimicrobial resistance will be responsible for 10 million global deaths annually, more deaths than cancer, costing the world economy $100 trillion. Clearly, strategies to address this problem are essential as bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::b7376335c41f4049a8ef8e1515fc1e58
https://eprints.whiterose.ac.uk/188157/5/d2md00049k.pdf
https://eprints.whiterose.ac.uk/188157/5/d2md00049k.pdf
Autor:
lykins, JD, Filippova, E, Halavaty, AS, Minasov, G, Zhou, Y, Dubrovska, I, Flores, KJ, Shuvalova, LA, Ruan, J, El Bissati, K, Dovgin, S, Roberts, CW, Woods, S, Moulton, JD, Moulton, H, McPhillie, MJ, Muench, SP, Fishwick, CWG, Sabini, E, Shanmugam, D, Roos, DS, McLeod, R, Anderson, WF, Ngô, HM
Toxoplasma gondii, an Apicomplexan parasite, causes significant morbidity and mortality, including severe disease in immunocompromised hosts and devastating congenital disease, with no effective treatment for the bradyzoite stage. To address this, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e1bde764546127fee236bd5bea05787e
https://eprints.whiterose.ac.uk/136789/6/fcimb-08-00352.pdf
https://eprints.whiterose.ac.uk/136789/6/fcimb-08-00352.pdf
Autor:
Amporndanai, K, Johnson, RM, O’Neil, PM, Fishwick, CWG, Jamson, AH, Rawson, S, Muench, SP, Hassnain, SS, Antonyuk, SV
Cytochrome bc₁, a dimeric multi-subunit electron-transport protein embedded in the inner mitochondrial membrane, is a major drug target for the treatment and prevention of malaria and toxoplasmosis. Structural studies of cytochrome bc₁ from mamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c5f297d4a27efc513ecc50edbf423886
https://eprints.whiterose.ac.uk/127000/3/ua5001.pdf
https://eprints.whiterose.ac.uk/127000/3/ua5001.pdf
Autor:
Cahill, ST, Cain, R, Wang, DY, Lohans, CT, Wareham, DW, Oswin, HP, Mohammed, J, Spencer, J, Fishwick, CWG, McDonough, MA, Schofield, CJ, Brem, J
β-Lactamase-mediated resistance is a growing threat to the continued use of β-lactam antibiotics. The use of the β-lactam-based serine-β-lactamase (SBL) inhibitors clavulanic acid, sulbactam, tazobactam, and, more recently, the non-β-lactam inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::501d89760e845b9146a9f5c83fb0c6f9
https://ora.ox.ac.uk/objects/uuid:0195e9e0-4bcc-4c81-86cc-b586ca7e3e39
https://ora.ox.ac.uk/objects/uuid:0195e9e0-4bcc-4c81-86cc-b586ca7e3e39
We describe here experiments which demonstrate the selective phospho-transfer from a plausibly prebiotic condensed phosphorus (P) salt, pyrophosphite [H2P2O52−; PPi(III)], to the phosphate group of 5′-adenosine mono phosphate (5′-AMP). We show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c68a4db2acbc40cdd8a80e181b133431
https://eprints.whiterose.ac.uk/103299/13/art%3A10.1007%2Fs11084-016-9497-y.pdf
https://eprints.whiterose.ac.uk/103299/13/art%3A10.1007%2Fs11084-016-9497-y.pdf
Autor:
Brem, J, Cain, R, Cahill, S, McDonough, MA, Clifton, IJ, Jimenez-Castellanos, JC, Avison, MB, Spencer, J, Fishwick, CWG, Schofield, CJ
Publikováno v:
Nature Communications
Brem, J, Cain, R, Cahill, S, McDonough, M A, Clifton, I J, Jiménez-Castellanos, J-C, Avison, M B, Spencer, J, Fishwick, C W G & Schofield, C J 2016, ' Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates ', Nature Communications, vol. 7, 12406 . https://doi.org/10.1038/ncomms12406
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Brem, J, Cain, R, Cahill, S, McDonough, M A, Clifton, I J, Jiménez-Castellanos, J-C, Avison, M B, Spencer, J, Fishwick, C W G & Schofield, C J 2016, ' Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates ', Nature Communications, vol. 7, 12406 . https://doi.org/10.1038/ncomms12406
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
β-Lactamases enable resistance to almost all β-lactam antibiotics. Pioneering work revealed that acyclic boronic acids can act as ‘transition state analogue' inhibitors of nucleophilic serine enzymes, including serine-β-lactamases. Here we repor
Autor:
Grigg, R, Elboray, EE, Akkarasamiyo, S, Chuanopparat, N, Dondas, HA, Abbas-Temirek, HH, Fishwick, CWG, Aly, MF, Kongkathip, B, Kongkathip, N
Palladium catalysed three component cascade process, involving coupling of 2-iodobenzoates, -benzaldehydes, or acetophenones with substituted allenes and ammonium tartrate as an ammonium surrogate, provides a novel and facile route to substituted fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::85a3ecf9e623fbb0109429a57f71068c
https://aperta.ulakbim.gov.tr/record/55865
https://aperta.ulakbim.gov.tr/record/55865
Autor:
Majeed, Y, Amer, MS, Agarwal, AK, McKeown, L, Porter, KE, O'Regan, DJ, Naylor, J, Fishwick, CWG, Muraki, K, Beech, DJ
Publikováno v:
British Journal of Pharmacology
BACKGROUND AND PURPOSE Transient receptor potential canonical 5 (TRPC5) channels are widely expressed, including in the CNS, where they potentiate fear responses. They also contribute to other non-selective cation channels that are stimulated by G-pr
Publikováno v:
Scientific Reports
The Escherichia coli endoribonuclease RNase E is central to the processing and degradation of all types of RNA and as such is a pleotropic regulator of gene expression. It is essential for growth and was one of the first examples of an endonuclease t
The development of antibacterial drugs based on novel chemotypes is essential to the future management of serious drug resistant infections. We herein report the design, synthesis and SAR of a novel series of N-ethylurea inhibitors based on a pyridin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3672803f44eb3d978657f7f6cac7f115
https://eprints.whiterose.ac.uk/84087/3/Eur_J_Med_Chem_PUC_paper_revised_CWGF.pdf
https://eprints.whiterose.ac.uk/84087/3/Eur_J_Med_Chem_PUC_paper_revised_CWGF.pdf