Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Autor: Justice, AE, Winkler, TW, Feitosa, MF, Graff, M, Fisher, VA, Young, K, Barata, L, Deng, X, Czajkowski, J, Hadley, D, Ngwa, JS, Ahluwalia, TS, Chu, AY, Heard-Costa, NL, Lim, E, Perez, J, Eicher, JD, Kutalik, Z, Xue, L, Mahajan, A, Renström, F, Wu, J, Qi, Q, Ahmad, S, Alfred, T, Amin, N, Bielak, LF, Bonnefond, A, Bragg, J, Cadby, G, Chittani, M, Coggeshall, S, Corre, T, Direk, N, Eriksson, J, Fischer, K, Gorski, M, Neergaard Harder, M, Horikoshi, M, Huang, T, Huffman, JE, Jackson, AU, Justesen, JM, Kanoni, S, Kinnunen, L, Kleber, ME, Komulainen, P, Kumari, M, Lim, U, Luan, J, Lyytikäinen, L-P, Mangino, M, Manichaikul, A, Marten, J, Middelberg, RPS, Müller-Nurasyid, M, Navarro, P, Pérusse, L, Pervjakova, N, Sarti, C, Smith, AV, Smith, JA, Stančáková, A, Strawbridge, RJ, Stringham, HM, Sung, YJ, Tanaka, T, Teumer, A, Trompet, S, Van Der Laan, SW, Van Der Most, PJ, Van Vliet-Ostaptchouk, JV, Vedantam, SL, Verweij, N, Vink, JM, Vitart, V, Wu, Y, Yengo, L, Zhang, W, Hua Zhao, J, Zimmermann, ME, Zubair, N, Abecasis, GR, Adair, LS, Afaq, S, Afzal, U, Bakker, SJL, Bartz, TM, Beilby, J, Bergman, RN, Bergmann, S, Biffar, R, Blangero, J, Boerwinkle, E, Bonnycastle, LL, Bottinger, E, Braga, D, Buckley, BM, Buyske, S, Campbell, H, Chambers, JC, Collins, FS, Curran, JE, De Borst, GJ, De Craen, AJM, De Geus, EJC, Dedoussis, G, Delgado, GE, Den Ruijter, HM, Eiriksdottir, G, Eriksson, AL, Esko, T, Faul, JD, Ford, I, Forrester, T, Gertow, K, Gigante, B, Glorioso, N, Gong, J, Grallert, H, Grammer, TB, Grarup, N, Haitjema, S, Hallmans, G, Hamsten, A, Hansen, T, Harris, TB, Hartman, CA, Hassinen, M, Hastie, ND, Heath, AC, Hernandez, D, Hindorff, L, Hocking, LJ, Hollensted, M, Holmen, OL, Homuth, G, Jan Hottenga, J, Huang, J, Hung, J, Hutri-Kähönen, N, Ingelsson, E, James, AL, Jansson, J-O, Jarvelin, M-R, Jhun, MA, Jørgensen, ME, Juonala, M, Kähönen, M, Karlsson, M, Koistinen, HA, Kolcic, I, Kolovou, G, Kooperberg, C, Krämer, BK, Kuusisto, J, Kvaløy, K, Lakka, TA, Langenberg, C, Launer, LJ, Leander, K, Lee, NR, Lind, L, Lindgren, CM, Linneberg, A, Lobbens, S, Loh, M, Lorentzon, M, Luben, R, Lubke, G, Ludolph-Donislawski, A, Lupoli, S, Madden, PAF, Männikkö, R, Marques-Vidal, P, Martin, NG, McKenzie, CA, McKnight, B, Mellström, D, Menni, C, Montgomery, GW, Musk, AB, Narisu, N, Nauck, M, Nolte, IM, Oldehinkel, AJ, Olden, M, Ong, KK, Padmanabhan, S, Peyser, PA, Pisinger, C, Porteous, DJ, Raitakari, OT, Rankinen, T, Rao, DC, Rasmussen-Torvik, LJ, Rawal, R, Rice, T, Ridker, PM, Rose, LM, Bien, SA, Rudan, I, Sanna, S, Sarzynski, MA, Sattar, N, Savonen, K, Schlessinger, D, Scholtens, S, Schurmann, C, Scott, RA, Sennblad, B, Siemelink, MA, Silbernagel, G, Slagboom, PE, Snieder, H, Staessen, JA, Stott, DJ, Swertz, MA, Swift, AJ, Taylor, KD, Tayo, BO, Thorand, B, Thuillier, D, Tuomilehto, J, Uitterlinden, AG, Vandenput, L, Vohl, M-C, Völzke, H, Vonk, JM, Waeber, G, Waldenberger, M, Westendorp, RGJ, Wild, S, Willemsen, G, Wolffenbuttel, BHR, Wong, A, Wright, AF, Zhao, W, Zillikens, MC, Baldassarre, D, Balkau, B, Bandinelli, S, Böger, CA, Boomsma, DI, Bouchard, C, Bruinenberg, M, Chasman, DI, Chen, Y-D, Chines, PS, Cooper, RS, Cucca, F, Cusi, D, Faire, UD, Ferrucci, L, Franks, PW, Froguel, P, Gordon-Larsen, P, Grabe, H-J, Gudnason, V, Haiman, CA, Hayward, C, Hveem, K, Johnson, AD, Wouter Jukema, J, Kardia, SLR, Kivimaki, M, Kooner, JS, Kuh, D, Laakso, M, Lehtimäki, T, Marchand, LL, März, W, McCarthy, MI, Metspalu, A, Morris, AP, Ohlsson, C, Palmer, LJ, Pasterkamp, G, Pedersen, O, Peters, A, Peters, U, Polasek, O, Psaty, BM, Qi, L, Rauramaa, R, Smith, BH, Sørensen, TIA, Strauch, K, Tiemeier, H, Tremoli, E, Van Der Harst, P, Vestergaard, H, Vollenweider, P, Wareham, NJ, Weir, DR, Whitfield, JB, Wilson, JF, Tyrrell, J, Frayling, TM, Barroso, I, Boehnke, M, Deloukas, P, Fox, CS, Hirschhorn, JN, Hunter, DJ, Spector, TD, Strachan, DP, Van Duijn, CM, Heid, IM, Mohlke, KL, Marchini, J, Loos, RJF, Kilpeläinen, TO, Liu, C-T, Borecki, IB, North, KE, Cupples, LA

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 c

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Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy in Patients With Metastatic Colorectal Cancer With Measures of Microsatellite Instability, Mismatch Repair, or Tumor Mutational Burden.

Autor: Quintanilha JCF; Foundation Medicine, Cambridge, Massachusetts., Graf RP; Foundation Medicine, Cambridge, Massachusetts., Fisher VA; Foundation Medicine, Cambridge, Massachusetts., Oxnard GR; Foundation Medicine, Cambridge, Massachusetts., Ellis H; Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital, Boston., Panarelli N; Medicine/Gastroenterology, Montefiore Medical Center, Albert Einstein Cancer Center, New York, New York., Lin DI; Foundation Medicine, Cambridge, Massachusetts., Li G; Foundation Medicine, Cambridge, Massachusetts., Huang RSP; Foundation Medicine, Cambridge, Massachusetts., Ross JS; Foundation Medicine, Cambridge, Massachusetts.; SUNY Upstate Medical University, Syracuse, New York., Myer PA; Medicine/Gastroenterology, Montefiore Medical Center, Albert Einstein Cancer Center, New York, New York., Klempner SJ; Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital, Boston.

Publikováno v: JAMA network open [JAMA Netw Open] 2023 Jan 03; Vol. 6 (1), pp. e2252244. Date of Electronic Publication: 2023 Jan 03.

Genetic predisposition to mosaic Y chromosome loss in blood.

Autor: Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Genovese G; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Halvardson J; Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Ulirsch JC; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA., Wright DJ; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Open Targets Core Genetics, Wellcome Sanger Institute, Hinxton, UK., Terao C; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.; Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Davidsson OB; deCODE Genetics, Amgen, Reykjavík, Iceland., Day FR; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Sulem P; deCODE Genetics, Amgen, Reykjavík, Iceland., Jiang Y; 23andMe, Mountain View, CA, USA., Danielsson M; Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Davies H; Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Dunlop MG; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit and CRUK Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Fisher VA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Zink F; deCODE Genetics, Amgen, Reykjavík, Iceland., Houlston RS; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK., Ingelsson M; Geriatrics Research Group, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Kar S; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Kerrison ND; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Kinnersley B; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK., Kristjansson RP; deCODE Genetics, Amgen, Reykjavík, Iceland., Law PJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK., Li R; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Loveday C; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK., Mattisson J; Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., McCarroll SA; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Murakami Y; Division of Molecular Pathology, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Murray A; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Olszewski P; Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland., Rychlicka-Buniowska E; Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland., Scott RA; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Thorsteinsdottir U; deCODE Genetics, Amgen, Reykjavík, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Tomlinson I; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Moghadam BT; Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Turnbull C; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.; William Harvey Research Institute, Queen Mary University, London, UK., Wareham NJ; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Gudbjartsson DF; deCODE Genetics, Amgen, Reykjavík, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavík, Iceland., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hoffmann ER; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Jackson SP; Department of Biochemistry, University of Cambridge, Cambridge, UK.; Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK., Stefansson K; deCODE Genetics, Amgen, Reykjavík, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Auton A; 23andMe, Mountain View, CA, USA., Ong KK; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Loh PR; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Dumanski JP; Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Forsberg LA; Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Beijer Laboratory of Genome Research, Uppsala University, Uppsala, Sweden., Perry JRB; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK. john.perry@mrc-epid.cam.ac.uk.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. john.perry@mrc-epid.cam.ac.uk.

Publikováno v: Nature [Nature] 2019 Nov; Vol. 575 (7784), pp. 652-657. Date of Electronic Publication: 2019 Nov 20.

What life course theoretical models best explain the relationship between exposure to childhood adversity and psychopathology symptoms: recency, accumulation, or sensitive periods?

Autor: Dunn EC; Center for Genomic Medicine, Massachusetts General Hospital,Boston, MA,USA., Soare TW; Center for Genomic Medicine, Massachusetts General Hospital,Boston, MA,USA., Raffeld MR; Center for Genomic Medicine, Massachusetts General Hospital,Boston, MA,USA., Busso DS; Center for Genomic Medicine, Massachusetts General Hospital,Boston, MA,USA., Crawford KM; Center for Genomic Medicine, Massachusetts General Hospital,Boston, MA,USA., Davis KA; Center for Genomic Medicine, Massachusetts General Hospital,Boston, MA,USA., Fisher VA; Center for Genomic Medicine, Massachusetts General Hospital,Boston, MA,USA., Slopen N; Department of Epidemiology and Biostatistics,School of Public Health, University of Maryland,College Park, MD,USA., Smith ADAC; Applied Statistics Group,University of the West of England,Bristol,UK., Tiemeier H; Erasmus Medical Center,Rotterdam,The Netherlands., Susser ES; Department of Epidemiology,Mailman School of Public Health, Columbia University,New York, NY,USA.

Publikováno v: Psychological medicine [Psychol Med] 2018 Nov; Vol. 48 (15), pp. 2562-2572. Date of Electronic Publication: 2018 Feb 26.