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Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.

Autor: Benyair R; Cell and Developmental Biology, University of Michigan, Ann Arbor, United States; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States., Giridharan SSP; Cell and Developmental Biology, University of Michigan, Ann Arbor, United States; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States., Rivero-Ríos P; Cell and Developmental Biology, University of Michigan, Ann Arbor, United States; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States., Hasegawa J; Cell and Developmental Biology, University of Michigan, Ann Arbor, United States; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States., Bristow E; Cell and Developmental Biology, University of Michigan, Ann Arbor, United States; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States., Eskelinen EL; Institute of Biomedicine, University of Turku, Turku, Finland., Shmueli MD; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel., Fishbain-Yoskovitz V; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel., Merbl Y; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel., Sharkey LM; Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States., Paulson HL; Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States., Hanson PI; Department of Biological Chemistry, University of Michigan School of Medicine, 1150 W. Medical Center Drive, Ann Arbor, Michigan, United States., Patnaik S; Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Al-Ramahi I; Department of Molecular and Human Genetics, Department of Molecular and Cellular Biology, Jan and Dan Duncan Neurological Research Institute, Houston, Texas, United States., Botas J; Department of Molecular and Human Genetics, Department of Molecular and Cellular Biology, Jan and Dan Duncan Neurological Research Institute, Houston, Texas, United States., Marugan J; Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Weisman LS; Cell and Developmental Biology, University of Michigan, Ann Arbor, United States; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States.

Publikováno v: Autophagy reports [Autophagy Rep] 2023; Vol. 2 (1). Date of Electronic Publication: 2023 Jan 22.