Efcab7 deletion sensitizes mice to the teratogenic effects of gastrulation-stage alcohol exposure.

Autor: Fish EW; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, United States., Boschen KE; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, United States., Parnell SE; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, United States; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, United States; Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, United States. Electronic address: sparnell@med.unc.edu.

Publikováno v: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2024 Dec; Vol. 130, pp. 108729. Date of Electronic Publication: 2024 Oct 02.

Gastrulation-stage alcohol exposure induces similar rates of craniofacial malformations in male and female C57BL/6J mice.

Autor: Boschen KE; Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA., Dragicevich CJ; Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Fish EW; Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Hepperla AJ; Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Simon JM; Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Parnell SE; Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Publikováno v: Birth defects research [Birth Defects Res] 2024 Jan; Vol. 116 (1), pp. e2292. Date of Electronic Publication: 2023 Dec 20.

The pro-apoptotic Bax gene modifies susceptibility to craniofacial dysmorphology following gastrulation-stage alcohol exposure.

Autor: Fish EW; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, USA., Mendoza-Romero HN; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, USA., Love CA; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, USA., Dragicevich CJ; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, USA., Cannizzo MD; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, USA., Boschen KE; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, USA., Hepperla A; Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, North Carolina, USA.; Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, USA., Simon JM; Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, North Carolina, USA.; Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, USA.; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Parnell SE; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, USA.; Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, North Carolina, USA.; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, USA.

Publikováno v: Birth defects research [Birth Defects Res] 2022 Nov 15; Vol. 114 (19), pp. 1229-1243. Date of Electronic Publication: 2022 Apr 09.

Loss of tumor protein 53 protects against alcohol-induced facial malformations in mice and zebrafish.

Autor: Fish EW; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, USA., Tucker SK; Department of Molecular Biosciences, Waggoner Center for Alcohol and Addiction Research and Institute for Neuroscience, University of Texas, Austin, Texas, USA., Peterson RL; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, USA., Eberhart JK; Department of Molecular Biosciences, Waggoner Center for Alcohol and Addiction Research and Institute for Neuroscience, University of Texas, Austin, Texas, USA., Parnell SE; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, USA.; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, USA.; Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, North Carolina, USA.

Publikováno v: Alcoholism, clinical and experimental research [Alcohol Clin Exp Res] 2021 Oct; Vol. 45 (10), pp. 1965-1979. Date of Electronic Publication: 2021 Sep 28.

Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction.

Autor: Fish EW; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA., Murdaugh LB; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA., Zhang C; Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA., Boschen KE; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA., Boa-Amponsem O; Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.; Integrated Biosciences Program, North Carolina Central University, Durham, NC, USA., Mendoza-Romero HN; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA., Tarpley M; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, USA., Chdid L; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, USA., Mukhopadhyay S; Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.; Department of Chemistry and Biochemistry, North Carolina Central University, Durham, NC, USA., Cole GJ; Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.; Department of Biological and Biomedical Sciences, North Carolina Central University, Durham, NC, USA., Williams KP; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, USA.; Department of Pharmaceutical Sciences, BRITE Institute, North Carolina Central University, Durham, NC, USA., Parnell SE; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA. sparnell@med.unc.edu.; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, USA. sparnell@med.unc.edu.; Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA. sparnell@med.unc.edu.

Publikováno v: Scientific reports [Sci Rep] 2019 Nov 05; Vol. 9 (1), pp. 16057. Date of Electronic Publication: 2019 Nov 05.