Preclinical Development of CAR T Cells with Antigen-Inducible IL18 Enforcement to Treat GD2-Positive Solid Cancers.

Autor: Fischer-Riepe L; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Kailayangiri S; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Zimmermann K; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany., Pfeifer R; Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany., Aigner M; Department of Internal Medicine 5 - Hematology and Oncology, Friedrich Alexander University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie (DZI), Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany., Altvater B; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Kretschmann S; Department of Internal Medicine 5 - Hematology and Oncology, Friedrich Alexander University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie (DZI), Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany., Völkl S; Department of Internal Medicine 5 - Hematology and Oncology, Friedrich Alexander University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie (DZI), Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany., Hartley J; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy (LIT) and University of Regensburg, Regensburg, Germany., Dreger C; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy (LIT) and University of Regensburg, Regensburg, Germany., Petry K; Miltenyi Biomedicine GmbH, Bergisch Gladbach, Germany., Bosio A; Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany., von Döllen A; Institute of Transfusion Medicine and Cell Therapy, University Hospital Muenster, Muenster, Germany., Hartmann W; Gerhard-Domagk-Institute of Pathology, University of Muenster, Muenster, Germany., Lode H; Pediatric Hematology-Oncology Department, University Medicine Greifswald, Greifswald, Germany., Görlich D; Institute of Biostatistics and Clinical Research, University of Muenster., Mackensen A; Department of Internal Medicine 5 - Hematology and Oncology, Friedrich Alexander University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie (DZI), Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany., Jungblut M; Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany., Schambach A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.; REBIRTH Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany., Abken H; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy (LIT) and University of Regensburg, Regensburg, Germany., Rossig C; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.; Institute of Transfusion Medicine and Cell Therapy, University Hospital Muenster, Muenster, Germany.; Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Muenster, Muenster, Germany.; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Aug 15; Vol. 30 (16), pp. 3564-3577.

Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on Monocytes.

Autor: Russo A; Institute of Immunology, University of Münster, 48149, Münster, Germany.; Cells in Motion Interfaculty Centre, University of Münster, 48149, Münster, Germany., Schürmann H; Institute of Cell Biology, Centre for Molecular Biology of Inflammation, ZMBE, University of Münster, 48149, Münster, Germany., Brandt M; Institute of Cell Biology, Centre for Molecular Biology of Inflammation, ZMBE, University of Münster, 48149, Münster, Germany., Scholz K; Institute of Immunology, University of Münster, 48149, Münster, Germany., Matos ALL; Cells in Motion Interfaculty Centre, University of Münster, 48149, Münster, Germany.; Institute of Medical Biochemistry, Centre of Molecular Biology of Inflammation, ZMBE, University of Münster, 48149, Münster, Germany., Grill D; Institute of Medical Biochemistry, Centre of Molecular Biology of Inflammation, ZMBE, University of Münster, 48149, Münster, Germany., Revenstorff J; Institute of Immunology, University of Münster, 48149, Münster, Germany., Rembrink M; Institute of Immunology, University of Münster, 48149, Münster, Germany., von Wulffen M; Institute of Immunology, University of Münster, 48149, Münster, Germany., Fischer-Riepe L; Institute of Immunology, University of Münster, 48149, Münster, Germany., Hanley PJ; Faculty of Medicine, HMU Health and Medical University Potsdam, 14471, Potsdam, Germany., Häcker H; Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT, 84112, USA., Prünster M; BioMedical Center, Walter-Brendel-Centre for Experimental Medicine, Ludwig-Maximilians-University, Planegg-Martinsried, 82152, Munich, Germany., Sánchez-Madrid F; Immunology Service, Hospital de la Princesa, Universidad Autónoma de Madrid, Instituto Investigación Sanitaria Princesa, Madrid, 28006, Spain.; Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain., Hermann S; European Institute for Molecular Imaging (EIMI), University of Münster, 48149, Münster, Germany., Klotz L; Department of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149, Muenster, Germany., Gerke V; Cells in Motion Interfaculty Centre, University of Münster, 48149, Münster, Germany.; Institute of Medical Biochemistry, Centre of Molecular Biology of Inflammation, ZMBE, University of Münster, 48149, Münster, Germany., Betz T; Cells in Motion Interfaculty Centre, University of Münster, 48149, Münster, Germany.; Institute of Cell Biology, Centre for Molecular Biology of Inflammation, ZMBE, University of Münster, 48149, Münster, Germany.; Third Institute of Physics- Biophysics, Georg August University Göttingen, 37077, Göttingen, Germany., Vogl T; Institute of Immunology, University of Münster, 48149, Münster, Germany., Roth J; Institute of Immunology, University of Münster, 48149, Münster, Germany.; Cells in Motion Interfaculty Centre, University of Münster, 48149, Münster, Germany.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 Dec; Vol. 9 (36), pp. e2201505. Date of Electronic Publication: 2022 Oct 30.

CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow.

Autor: Fischer-Riepe L; Institute of Immunology, University of Muenster, Muenster, Germany., Daber N; Institute of Immunology, University of Muenster, Muenster, Germany., Schulte-Schrepping J; Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany., Véras De Carvalho BC; Institute of Immunology, University of Muenster, Muenster, Germany., Russo A; Institute of Immunology, University of Muenster, Muenster, Germany., Pohlen M; Institute of Immunology, University of Muenster, Muenster, Germany; Department of Medicine A, Hematology and Oncology, University Hospital of Muenster, Muenster, Germany., Fischer J; Institute of Molecular Tumor Biology, University of Muenster, Muenster, Germany., Chasan AI; Institute of Immunology, University of Muenster, Muenster, Germany., Wolf M; Institute of Immunology, University of Muenster, Muenster, Germany., Ulas T; Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany., Glander S; Institute of Human Genetics, Genetic Epidemiology, University of Muenster, Muenster, Germany., Schulz C; Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Skryabin B; Department of Medicine, Transgenic Animal and Genetic Engineering Models, University of Muenster, Muenster, Germany., Wollbrink Dipl-Ing A; Institute for Biomagnetism and Biosignalanalysis, University of Muenster, Muenster, Germany., Steingraeber N; Institute for Biomagnetism and Biosignalanalysis, University of Muenster, Muenster, Germany., Stremmel C; Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany., Koehle M; Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany., Gärtner F; Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany., Vettorazzi S; Institute of Comparative Molecular Endocrinology (CME), University of Ulm, Ulm, Germany., Holzinger D; Institute of Immunology, University of Muenster, Muenster, Germany., Gross J; Institute for Biomagnetism and Biosignalanalysis, University of Muenster, Muenster, Germany., Rosenbauer F; Institute of Molecular Tumor Biology, University of Muenster, Muenster, Germany., Stoll M; Institute of Human Genetics, Genetic Epidemiology, University of Muenster, Muenster, Germany., Niemann S; Institute of Medical Microbiology, University Hospital Muenster, Muenster, Germany., Tuckermann J; Institute of Comparative Molecular Endocrinology (CME), University of Ulm, Ulm, Germany., Schultze JL; Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany; Platform for Single Cell Genomics and Epigenomics (PRECISE) at the DZNE and the University of Bonn, Bonn, Germany., Roth J; Institute of Immunology, University of Muenster, Muenster, Germany; Interdisciplinary Centre for Clinical Research, University of Muenster, Muenster, Germany., Barczyk-Kahlert K; Institute of Immunology, University of Muenster, Muenster, Germany. Electronic address: bar@uni-muenster.de.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2020 Nov; Vol. 146 (5), pp. 1137-1151. Date of Electronic Publication: 2020 Mar 19.

PPARγ activation ameliorates cognitive impairment and chronic microglial activation in the aftermath of r-mTBI.

Autor: Pearson, Andrew^1,2 (AUTHOR) apearson@roskampinstitute.org, Koprivica, Milica¹ (AUTHOR), Eisenbaum, Max^1,2 (AUTHOR), Ortiz, Camila^1,2 (AUTHOR), Browning, Mackenzie¹ (AUTHOR), Vincennie, Tessa¹ (AUTHOR), Tinsley, Cooper¹ (AUTHOR), Mullan, Michael¹ (AUTHOR), Crawford, Fiona^1,2,3 (AUTHOR), Ojo, Joseph^1,2,3 (AUTHOR)

Publikováno v: Journal of Neuroinflammation. 8/3/2024, Vol. 21 Issue 1, p1-24. 24p.

Harnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design.

Autor: Axer A; Institute for Organic Chemistry, WWU Münster, Corrensstrasse 40, 48149, Münster, Germany.; DFG EXC 1003 Cluster of Excellence 'Cells in Motion', WWU Münster, Münster, Germany., Hermann S; European Institute for Molecular Imaging, WWU Münster, Waldeyerstrasse 15, 48149, Münster, Germany.; Interdisciplinary Center of Clinical Research (IZKF), University Hospital Münster, 48149, Münster, Germany.; DFG EXC 1003 Cluster of Excellence 'Cells in Motion', WWU Münster, Münster, Germany., Kehr G; Institute for Organic Chemistry, WWU Münster, Corrensstrasse 40, 48149, Münster, Germany., Clases D; Institute for Inorganic and Analytical Chemistry, WWU Münster, Corrensstrasse 30, 48149, Münster, Germany., Karst U; Institute for Inorganic and Analytical Chemistry, WWU Münster, Corrensstrasse 30, 48149, Münster, Germany.; DFG EXC 1003 Cluster of Excellence 'Cells in Motion', WWU Münster, Münster, Germany., Fischer-Riepe L; Institute for Immunology, WWU Münster, Röntgenstrasse 21, 48149, Münster, Germany., Roth J; Institute for Immunology, WWU Münster, Röntgenstrasse 21, 48149, Münster, Germany.; Interdisciplinary Center of Clinical Research (IZKF), University Hospital Münster, 48149, Münster, Germany.; DFG EXC 1003 Cluster of Excellence 'Cells in Motion', WWU Münster, Münster, Germany., Fobker M; Center of Laboratory Medicine, WWU Münster, Albert Schweitzer Campus 1, 48149, Münster, Germany., Schäfers M; European Institute for Molecular Imaging, WWU Münster, Waldeyerstrasse 15, 48149, Münster, Germany.; Interdisciplinary Center of Clinical Research (IZKF), University Hospital Münster, 48149, Münster, Germany.; Department of Nuclear Medicine, University Hospital Münster, Albert Schweitzer Campus 1, 48149, Münster, Germany.; DFG EXC 1003 Cluster of Excellence 'Cells in Motion', WWU Münster, Münster, Germany., Gilmour R; Institute for Organic Chemistry, WWU Münster, Corrensstrasse 40, 48149, Münster, Germany.; DFG EXC 1003 Cluster of Excellence 'Cells in Motion', WWU Münster, Münster, Germany., Faust A; European Institute for Molecular Imaging, WWU Münster, Waldeyerstrasse 15, 48149, Münster, Germany.; Interdisciplinary Center of Clinical Research (IZKF), University Hospital Münster, 48149, Münster, Germany.; DFG EXC 1003 Cluster of Excellence 'Cells in Motion', WWU Münster, Münster, Germany.

Publikováno v: ChemMedChem [ChemMedChem] 2018 Feb 06; Vol. 13 (3), pp. 241-250. Date of Electronic Publication: 2018 Jan 16.