Geometrically defined environments direct cell division rate and subcellular YAP localization in single mouse embryonic stem cells

Autor: Bertels, Sarah, Jaggy, Mona, Richter, Benjamin, Keppler, Stephan, Weber, Kerstin, Genthner, Elisa, Fischer, Andrea C., Thiel, Michael, Wegener, Martin, Greiner, Alexandra M., Autenrieth, Tatjana J., Bastmeyer, Martin

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, 11 (1), Art.-Nr.: 9269

Mechanotransduction via yes-associated protein (YAP) is a central mechanism for decision-making in mouse embryonic stem cells (mESCs). Nuclear localization of YAP is tightly connected to pluripotency and increases the cell division rate (CDR). How th

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Geometrically defined environments direct cell division rate and subcellular YAP localization in single mouse embryonic stem cells.

Autor: Bertels S; Zoological Institute, Cell- and Neurobiology, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany.; Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.; 3DMM2O - Cluster of Excellence (EXC-2082/1 - 390761711), Karlsruhe, Germany., Jaggy M; Zoological Institute, Cell- and Neurobiology, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany.; Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany., Richter B; Zoological Institute, Cell- and Neurobiology, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany., Keppler S; Zoological Institute, Cell- and Neurobiology, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany.; 3DMM2O - Cluster of Excellence (EXC-2082/1 - 390761711), Karlsruhe, Germany., Weber K; Zoological Institute, Cell- and Neurobiology, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany., Genthner E; Zoological Institute, Cell- and Neurobiology, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany.; 3DMM2O - Cluster of Excellence (EXC-2082/1 - 390761711), Karlsruhe, Germany., Fischer AC; Zoological Institute, Cell- and Neurobiology, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany.; Institute of Applied Physics, Karlsruhe Institute of Technology, Wolfgang-Gaede-Straße 1, 76131, Karlsruhe, Germany., Thiel M; Nanoscribe GmbH, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany., Wegener M; Institute of Applied Physics, Karlsruhe Institute of Technology, Wolfgang-Gaede-Straße 1, 76131, Karlsruhe, Germany.; Institute of Nanotechnology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.; 3DMM2O - Cluster of Excellence (EXC-2082/1 - 390761711), Karlsruhe, Germany., Greiner AM; Zoological Institute, Cell- and Neurobiology, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany., Autenrieth TJ; Zoological Institute, Cell- and Neurobiology, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany.; Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany., Bastmeyer M; Zoological Institute, Cell- and Neurobiology, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany. bastmeyer@kit.edu.; Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany. bastmeyer@kit.edu.; 3DMM2O - Cluster of Excellence (EXC-2082/1 - 390761711), Karlsruhe, Germany. bastmeyer@kit.edu.; Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany. bastmeyer@kit.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Apr 29; Vol. 11 (1), pp. 9269. Date of Electronic Publication: 2021 Apr 29.