Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Fisayo A, Olotu"'
Publikováno v:
Biomedical Journal, Vol 44, Iss 4, Pp 447-460 (2021)
Background: The increase in global mortality rates from SARS-COV2 (COVID-19) infection has been alarming thereby necessitating the continual search for viable therapeutic interventions. Due to minimal microbial components, subunit (peptide-based) vac
Externí odkaz:
https://doaj.org/article/63b72f751ebb490eb0c697e3843021c2
Autor:
Fisayo A. Olotu, Mahmoud E.S. Soliman
Publikováno v:
Biomedical Journal, Vol 44, Iss 3, Pp 317-337 (2021)
Background: The ongoing search for viable treatment options to curtail Epstein Barr Virus (EBV) pathogenicity has necessitated a paradigmatic shift towards the design of peptide-based vaccines. Potential B-cell and T-cell epitopes were predicted for
Externí odkaz:
https://doaj.org/article/24e5c332c2ee43e7b953bee07e1024aa
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 16, Iss , Pp 573-586 (2018)
Over the years, numerous synthetic approaches have been utilized in drug design to improve the pharmacological properties of naturally derived compounds and most importantly, minimize toxic effects associated with their transition to drugs. The reduc
Externí odkaz:
https://doaj.org/article/fc1b553e8af24dafbbf55107812f0657
Publikováno v:
Informatics in Medicine Unlocked, Vol 21, Iss , Pp 100451- (2020)
The systematic entry of SARS-CoV-2 into host cells, as mediated by its Spike (S) protein, is highly essential for pathogenicity in humans. Hence, targeting the viral entry mechanisms remains a major strategy for COVID-19 treatment. Although recent ef
Externí odkaz:
https://doaj.org/article/7e7a9bb7b54a4bc699f072ec7ed148d6
Publikováno v:
Letters in Drug Design & Discovery. 19:379-386
Poly ADP-ribose polymerase-1 (PARP-1), due to its role in DNA damage and repair, has been identified as a crucial therapeutic target to attenuate cancer development and progression. More so, selective inhibition has remained a focal point in PARP-1 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27c635d4439a0e4af6d4293df7260eff
https://doi.org/10.2174/1570180818666210401131531
https://doi.org/10.2174/1570180818666210401131531
Publikováno v:
Current Pharmaceutical Biotechnology. 23:444-456
Background: Fragment-based drug discovery in recent times has been explored in the design of highly potent therapeutics. Methods: In this study, we explored the inhibitory dynamics of Compound 38 (Cpd38), a newly synthesized Bromodomain-containing pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ea2d0c108a8b94e1e51cdd2c9f7cc5
https://doi.org/10.2174/1389201022666210322122056
https://doi.org/10.2174/1389201022666210322122056
Autor:
Fisayo A. Olotu, Mahmoud E. Soliman
Publikováno v:
Molecules, Vol 25, Iss 18, p 4247 (2020)
Mycobacterium tuberculosis (Mtb) serine/threonine (Ser/Thr) Protein kinases A (PknA) and B (PknB) have been identified as highly attractive targets for overcoming drug resistant tuberculosis. A recent lead series optimization study yielded compound 3
Externí odkaz:
https://doaj.org/article/c2f1ae0d05d4404cb479672e04c57419
Publikováno v:
Cell Biochemistry and Biophysics
The recently emerged SARS-like coronavirus (SARS-CoV-2) has continued to spread rapidly among humans with alarming upsurges in global mortality rates. A major key to tackling this virus is to disrupt its RNA replication process as previously reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f8a54289764b41259a3a667c887507
http://europepmc.org/articles/PMC8014903
http://europepmc.org/articles/PMC8014903
Publikováno v:
The Protein Journal. 40:166-174
Upregulation of Heme Oxygenase-1 (HO-1) has been widely implicated in cancer growth and chemoresistance. This explains the numerous drug discovery efforts aimed at mitigating its pro-carcinogenic roles till date. In a recent study, two selective azol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030df39f257fc9985eca8eb25afa5f9d
https://doi.org/10.1007/s10930-021-09969-6
https://doi.org/10.1007/s10930-021-09969-6
Publikováno v:
Current pharmaceutical biotechnology.
Background: Parkinson’s disease (PD) is one of the most prominent neurodegenerative diseases hence the continual search for viable and effective treatment options. The pathogeny of PD is driven by many key proteins among which is the recently ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1aa3dbde67bae51f6e1c2820f1351f2
https://pubmed.ncbi.nlm.nih.gov/35616668
https://pubmed.ncbi.nlm.nih.gov/35616668