Infigratinib (BGJ 398), a Pan-FGFR Inhibitor, Targets P-Glycoprotein and Increases Chemotherapeutic-Induced Mortality of Multidrug-Resistant Tumor Cells

Autor: Sergei Boichuk, Pavel Dunaev, Ilshat Mustafin, Shinjit Mani, Kirill Syuzov, Elena Valeeva, Firuza Bikinieva, Aigul Galembikova

Publikováno v: Biomedicines, Vol 10, Iss 3, p 601 (2022)

The microtubule-targeting agents (MTAs) are well-known chemotherapeutic agents commonly used for therapy of a broad spectrum of human malignancies, exhibiting epithelial origin, including breast, lung, and prostate cancer. Despite the impressive resp

Externí odkaz: https://doaj.org/article/982aa04a1252421fb9c4eed7c2236797

2-APCAs, the Novel Microtubule Targeting Agents Active against Distinct Cancer Cell Lines

Autor: Sergei Boichuk, Aigul Galembikova, Firuza Bikinieva, Pavel Dunaev, Aida Aukhadieva, Kirill Syuzov, Svetlana Zykova, Nazim Igidov, Alexander Ksenofontov, Pavel Bocharov

Publikováno v: Molecules, Vol 26, Iss 3, p 616 (2021)

Microtubules are known as the most attractive molecular targets for anti-cancer drugs. However, the number of serious limitations of the microtubule targeting agents (MTAs) including poor bioavailability, adverse effects (e.g., systemic and neural to

Externí odkaz: https://doaj.org/article/a9ef501aa1d042889535eae6c41d658c

Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair

Autor: Ilmira Nurgatina, Pavel Dunaev, Firuza Bikinieva, Sergei Boichuk, Aida Aukhadieva, Elena Valeeva, A R Galembikova, Alexey Sabirov

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 8842, p 8842 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 21; Issue 22; Pages: 8842

Activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is well documented for a broad spectrum of human malignancies supporting their growth and progression. Accumulating evidence has also implicated AKT as a potent modulator of anti-can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e833d18928ee1f6c4477c6823b664b77
https://pubmed.ncbi.nlm.nih.gov/33266502

The Design, Synthesis, and Biological Activities of Pyrrole-Based Carboxamides: The Novel Tubulin Inhibitors Targeting the Colchicine-Binding Site

Autor: S. S. Zykova, Sergei Boichuk, Maria Novikova, A R Galembikova, Pavel Dunaev, Ksenia Gankova, Pavel Kopnin, N. M. Igidov, Firuza Bikinieva, Kirill Syuzov, Aida Aukhadieva

Publikováno v: Molecules, Vol 26, Iss 5780, p 5780 (2021)
Molecules
Volume 26
Issue 19

Microtubule targeting agents (MTAs) that interfere with the dynamic state of the mitotic spindle are well-known and effective chemotherapeutic agents. These agents interrupt the microtubule network via polymerization or depolymerization, halting the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fcb7721943c55a86f6669053453e26
https://doi.org/10.3390/molecules26195780