Zobrazeno 1 - 10
of 2 490
pro vyhledávání: '"First in human"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundParkinson’s disease psychosis (PDP) is a common and distressing complication of Parkinson’s disease (PD), characterized by hallucinations and delusions. This research aimed to assess the pharmacokinetics and safety of NH130, a selective
Externí odkaz:
https://doaj.org/article/27cf86ff44954fdeb3d0f5edf77681e3
Autor:
Ute Klinkhardt, Mirjam Schunk, John Ervin, Christoph Schindler, Danny Sugimoto, Bruce Rankin, Ralf Amann, Martina Monti, Anna Kutschenko, Carsten Schumacher, Kristina Huber, Andreas Zeder, Nelli Heikkila, Arnaud M. Didierlaurent, Sylvia E. Schwarz, Madiha Derouazi
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Next-generation COVID-19 vaccines are being developed to expand the breadth of coverage against existing and future variants and to extend the duration of protection. Prime-2-CoV_Beta is an orf virus (ORFV) based multi-antigen COVID-19 vaccine that c
Externí odkaz:
https://doaj.org/article/ac42958aa7f6453581c61e1316c600ce
Autor:
Mai Han, Bishan Huo, Gaoyun Hu, Xin Zhang, Gang Cui, Wei Wu, Na Mi, Shixi Zhang, Jiangli Jin, Xing Lu, Bidong Wu, Chunyan Xiao, Jing Wang, Zheng Bian, Jintong Li
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundMefunidone is a novel synthetic compound and is better when compared to pirfenidone for the anti-fibrotic treatment of renal fibrosis in end-stage renal disease. We conducted this first-in-human, phase I clinical trial to determine the safe
Externí odkaz:
https://doaj.org/article/6d38864a099a4f61b53f25aa58f02dbc
Autor:
Rajbharan Yadav, Suzanne Schubbert, Patrick G. Holder, Eugene Y. Chiang, Nargess Kiabi, Liz Bogaert, Irene Leung, Rumana Rashid, Kendra N. Avery, Christine Bonzon, John R. Desjarlais, Shomyseh Sanjabi, Amy Sharma, Michelle Lepherd, Amy Shelton, Pam Chan, Yanqiu Liu, Louis Joslyn, Iraj Hosseini, Eric G. Stefanich, Amrita V. Kamath, Matthew J. Bernett, Vittal Shivva
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionInterleukin 15 (IL-15) is a potential anticancer agent and numerous engineered IL-15 agonists are currently under clinical investigation. Selective targeting of IL-15 to specific lymphocytes may enhance therapeutic effects while helping t
Externí odkaz:
https://doaj.org/article/31030b79b4034614806d2f9e04a075ba
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background The mammalian target of rapamycin (mTOR) kinase, a central component of the PI3K/AKT/mTOR pathway, plays a critical role in tumor biology as an attractive therapeutic target. We conducted this first-in-human study to investigate t
Externí odkaz:
https://doaj.org/article/0116ecedf75541d9827069d3e5bddbc2
Autor:
Faizus Sazzad, Ying Kiat Tan, Li Xuan Beverly Chan, Irwan Shah Bin Mohd Moideen, Abdulrahman El Gohary, John C. Stevens, K. R. Ramanathan, Theo Kofidis
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 18, Iss 1, Pp 1-11 (2023)
Abstract Background The aim of this review was the creation of uniform protocols to carry out and disclose First-In-Human and preliminary clinical trials of biological mitral valve replacement. The need for consistent methodology in these early trial
Externí odkaz:
https://doaj.org/article/f86eb2b19592420dbed0e2f168a49534
Autor:
Christopher John Wynne, Alexandra Cole, Charlotte Lemech, Guoqin Wang, Yu Zhang, Benchao Chen, Max Wang, Baiyong Li, Michelle Xia, Rodney Sinclair
Publikováno v:
Dermatology and Therapy, Vol 13, Iss 10, Pp 2357-2373 (2023)
Abstract Introduction Interleukin-4 (IL-4) and interleukin-13 (IL-13) are two essential cytokines involved in the T helper 2 (Th2)-mediated inflammatory response to diseases, such as atopic dermatitis (AD). AK120 is a humanized immunoglobulin G subcl
Externí odkaz:
https://doaj.org/article/790d2a45fabb4f539a324f49d5b7130a
Autor:
Takami Ishizuka, Hirofumi Komaki, Yasuko Asahina, Harumasa Nakamura, Norio Motohashi, Eri Takeshita, Yuko Shimizu‐Motohashi, Akihiko Ishiyama, Chihiro Yonee, Shinsuke Maruyama, Eisuke Hida, Yoshitsugu Aoki
Publikováno v:
Neuropsychopharmacology Reports, Vol 43, Iss 2, Pp 277-286 (2023)
Abstract Aim The purpose of this study is to evaluate the safety and pharmacokinetics of the novel morpholino oligomer NS‐089/NCNP‐02 which can induce exon 44 skipping, in patients with DMD. Additionally, we aimed to identify markers predictive o
Externí odkaz:
https://doaj.org/article/ee15b39e2405482aa4a970d87a49bf53
Autor:
Yuqi Wang, Quan Quan, Camille Gleason, Helin Yu, Lujia Peng, Yanshen Kang, Ling Jiang, Kailun Wu, Jie Pan, Moxiyele Bao, Qing Zhu, Meiqi Yi, Ming Fang, Yue Zheng, Ling Qiu, Bin Xu, Xiang Li, Jinfeng Song, Jiamu Sun, Zheng Zhang, Zijun Su, Jara Lin, Yuanyuan Xie, April Xu, Xiling Song, Chichi Huang, Zhirong Shen, Lai Wang, Jing Song
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTPharmaceutical companies have recently focused on accelerating the timeline for initiating first-in-human (FIH) trials to allow quick assessment of biologic drugs. For example, a stable cell pool can be used to produce materials for the toxic
Externí odkaz:
https://doaj.org/article/ba17fb85493c4f9899ea329c80eb8296
Autor:
Marcus J. Drake, Katherine Anderson, Andrew Gammie, Nicola Morris, Tony Timlin, Nikki Cotterill, John Duff, Mandy Fader, Hazel Taylor, Roger Holmes, John Havard
Publikováno v:
Continence, Vol 8, Iss , Pp 101054- (2023)
Purpose:: Evaluation of a catheter design which protects its tip with the retaining balloon when inflated, and has eyeholes at the base of the balloon to improve drainage. Materials and methods:: Preclinical tests included assessment of retaining bal
Externí odkaz:
https://doaj.org/article/cc82f0d3e08b4122954f8f00608c7d46