Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Firoz Roshan"'
Autor:
Yuniesky Andrade-Talavera, Gefei Chen, Firoz Roshan Kurudenkandy, Jan Johansson, André Fisahn
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105514- (2021)
Synchronized and properly balanced electrical activity of neurons is the basis for the brain's ability to process information, to learn, and to remember. In Alzheimer's disease (AD), which causes cognitive decline in patients, this synchronization an
Externí odkaz:
https://doaj.org/article/081544001b524b129897d89deaf47515
Autor:
Gefei Chen, Axel Abelein, Harriet E. Nilsson, Axel Leppert, Yuniesky Andrade-Talavera, Simone Tambaro, Lovisa Hemmingsson, Firoz Roshan, Michael Landreh, Henrik Biverstål, Philip J. B. Koeck, Jenny Presto, Hans Hebert, André Fisahn, Jan Johansson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The BRICHOS domain is a chaperone that can act against amyloid-β peptide fibril formation and non-fibrillar protein aggregation. Here the authors use a multidisciplinary approach and show that the Bri2 BRICHOS domain has qualitatively different chap
Externí odkaz:
https://doaj.org/article/54f4eca3feec44a6b3d1e292c044e1a5
Akademický článek
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Publikováno v:
Hippocampus. 30:101-113
Gamma oscillations (30-80 Hz) are fast network activity patterns frequently linked to cognition. They are commonly studied in hippocampal brain slices in vitro, where they can be evoked via pharmacological activation of various receptor families. One
Autor:
Lorena Galan-Acosta, Jyotirmoy Maity, Firoz Roshan, Erik Hjorth, Alok Juneja, Lennart Nilsson, Henrik Biverstål, Dmytro Honcharenko, Roger Strömberg, Jan Johansson, André Fisahn
Publikováno v:
ACS chemical neuroscience. 10(3)
A new generation of ligands designed to interact with the α-helix/β-strand discordant region of the amyloid-β peptide (Aβ) and to counteract its oligomerization is presented. These ligands are designed to interact with and stabilize the Aβ centr
Autor:
Philip J.B. Koeck, Jan Johansson, Axel Abelein, Jenny Presto, Henrik Biverstål, Lovisa Hemmingsson, Gefei Chen, Michael Landreh, André Fisahn, Yuniesky Andrade-Talavera, Harriet Nilsson, Firoz Roshan, Axel Leppert, Simone Tambaro, Hans Hebert
Publikováno v:
Nature communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Protein misfolding and aggregation is increasingly being recognized as a cause of disease. In Alzheimer’s disease the amyloid-β peptide (Aβ) misfolds into neurotoxic oligomers and assembles into amyloid fibrils. The Bri2 protein associated with F
Autor:
Roger Strömberg, Jyotirmoy Maity, Dmytro Honcharenko, Jan Johansson, Lennart Nilsson, Henrik Biverstål, André Fisahn, Firoz Roshan Kurudenkandy, Partha Pratim Bose, Erik Flöistrup, Alok Juneja
Publikováno v:
Org. Biomol. Chem.. 12:6684-6693
Peptide-like compounds containing an arginine have been shown to bind and stabilize the central helix of the Alzheimer's disease related amyloid-β peptide (Aβ) in an α-helical conformation, thereby delaying its aggregation into cytotoxic species.
Autor:
Firoz Roshan Kurudenkandy, Helen Poska, Jenny Presto, Sophie Crux, Martin Haslbeck, Henrik Biverstål, Erik Hermansson, Jan Johansson, Gefei Chen, André Fisahn, George Kostallas, Axel Abelein
Publikováno v:
Biochemical journal 473(20), 3683-3704 (2016). doi:10.1042/BCJ20160277
Formation of fibrils of the amyloid-β peptide (Aβ) is suggested to play a central role in neurodegeneration in Alzheimer's disease (AD), for which no effective treatment exists. The BRICHOS domain is a part of several disease-related proproteins, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15506920f3caad5dc42e7781da33734
https://pub.dzne.de/record/139035
https://pub.dzne.de/record/139035
Publikováno v:
Alzheimer's & Dementia. 11
Autor:
Jenny Presto, Dmytro Honcharenko, André Fisahn, Firoz Roshan Kurudenkandy, Roger Strömberg, Henrik Biverstål, Bengt Winblad, Misha Zilberter, Jan Johansson
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(34)
The amyloid-β hypothesis of Alzheimer's Disease (AD) focuses on accumulation of amyloid-β peptide (Aβ) as the main culprit for the myriad physiological changes seen during development and progression of AD including desynchronization of neuronal a