Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Firdous A. Khanday"'
1
Akademický článek
Quercetin suppresses ROS production and migration by specifically targeting Rac1 activation in gliomas
Autor: Rafia A. Baba, Hilal A. Mir, Taseem A. Mokhdomi, Hina F. Bhat, Ajaz Ahmad, Firdous A. Khanday
Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)
P66Shc and Rac1 proteins are responsible for tumor-associated inflammation, particularly in brain tumors characterized by elevated oxidative stress and increased reactive oxygen species (ROS) production. Quercetin, a natural polyphenolic flavonoid, i
Externí odkaz: https://doaj.org/article/98ef9c3e76304a92a4a0e9c96a529767
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2
Akademický článek
Actin Modulation Regulates the Alpha-1-Syntrophin/p66Shc Mediated Redox Signaling Contributing to the RhoA GTPase Protein Activation in Breast Cancer Cells
Autor: Roshia Ali, Hilal Ahmad Mir, Rabia Hamid, Basharat Bhat, Riaz A. Shah, Firdous A. Khanday, Sahar Saleem Bhat
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
SNTA1 signaling axis plays an essential role in cytoskeletal organization and is also implicated in breast cancers. In this study, we aimed to investigate the involvement of actin cytoskeleton in the propagation of SNTA1/p66shc mediated pro-metastati
Externí odkaz: https://doaj.org/article/b65b5d7b350a4ac9a7308c10c0f5fdaf
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4
Jasplakinolide Attenuates Cell Migration by Impeding Alpha-1-syntrophin Protein Phosphorylation in Breast Cancer Cells
Autor: Riaz A. Shah, Rabia Hamid, Sahar Saleem Bhat, Firdous A. Khanday, Hilal Ahmad Mir, Roshia Ali
Publikováno v: The Protein Journal. 40:234-244
Alpha-1-syntrophin (SNTA1) is emerging as a novel modulator of the actin cytoskeleton. SNTA1 binds to F-actin and regulates intracellular localization and activity of various actin organizing signaling molecules. Aberration in syntrophin signaling ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b8c3c8515ed217b313564c8b50c4ee
https://doi.org/10.1007/s10930-021-09963-y
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6
Flavonoid Treatment of Breast Cancer Cells has Multifarious Consequences on Alpha-1-Syntrophin Expression and other Downstream Processes
Autor: Sahar Saleem Bhat, Firdous A. Khanday, Umar Mushtaq, Roshia Ali
Publikováno v: Arabian Journal for Science and Engineering. 45:4511-4516
Alpha-1-syntrophin (SNTA1) is emerging as an important regulator of cell signaling. SNTA1 forms a part of the dystrophin glycoprotein complex (DGC) and takes part in signaling pathways via the DGC. SNTA1 has been seen to be over expressed in various
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58c4e4a60f59d72c2215f819a459c47b
https://doi.org/10.1007/s13369-020-04508-4
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10
Pro-oxidant vitamin C mechanistically exploits p66Shc/Rac1 GTPase pathway in inducing cytotoxicity
Autor: Hilal Ahmad Mir, Roshia Ali, Zahoor Ahmad Wani, Firdous Ahmad Khanday
Publikováno v: International journal of biological macromolecules. 205
P66Shc is the master regulator of oxidative stress whose pro-oxidant functioning is governed by ser36 phosphorylation. Phosphorylated p66Shc via Rac1 GTPase activation modulates ROS levels which in turn influence its pro-oxidative functions. Vitamin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d36495ba950b5b9c3f7f2a3988b31a
https://pubmed.ncbi.nlm.nih.gov/35181322
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