RICTOR/mTORC2 downregulation in BRAF ^V600E melanoma cells promotes resistance to BRAF/MEK inhibition.

Autor: Ponzone L; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Audrito V; Department of Science and Technological Innovation, University of Piemonte Orientale, Alessandria, 15121, Italy., Landi C; Functional Proteomic Section, Department of Life Sciences, University of Siena, Siena, 53100, Italy., Moiso E; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA., Levra Levron C; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Life Sciences and Systems Biology, University of Turin, Turin, 10126, Italy., Ferrua S; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Savino A; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Vitale N; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Gasparrini M; Department of Agriculture, Food and Environmental Sciences, Polytechnic University of Marche, Ancona, 60131, Italy., Avalle L; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy.; Department of Science and Technological Innovation, University of Piemonte Orientale, Alessandria, 15121, Italy., Vantaggiato L; Functional Proteomic Section, Department of Life Sciences, University of Siena, Siena, 53100, Italy., Shaba E; Functional Proteomic Section, Department of Life Sciences, University of Siena, Siena, 53100, Italy., Tassone B; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy.; Department of Personal Care, dsm-firmenich, Kaiseraugst, 4303, Switzerland., Saoncella S; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Orso F; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Viavattene D; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Marina E; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Fiorilla I; Department of Science and Technological Innovation, University of Piemonte Orientale, Alessandria, 15121, Italy., Burrone G; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy.; Department of Clinical and Biological Sciences, University of Turin, Turin, 10124, Italy., Abili Y; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy.; GenomeUp, Rome, 00144, Italy., Altruda F; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Bini L; Functional Proteomic Section, Department of Life Sciences, University of Siena, Siena, 53100, Italy., Deaglio S; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Medical Sciences, University of Turin, Turin, 10124, Italy., Defilippi P; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Menga A; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Poli V; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Porporato PE; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Provero P; Neuroscience Department 'Rita Levi Montalcini', University of Turin, Turin, 10126, Italy., Raffaelli N; Department of Agriculture, Food and Environmental Sciences, Polytechnic University of Marche, Ancona, 60131, Italy., Riganti C; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Oncology, University of Turin, Turin, 10124, Italy., Taverna D; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Cavallo F; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy., Calautti E; Molecular Biotechnology Center 'Guido Tarone', University of Turin, Turin, 10126, Italy. vincenzo.calautti@unito.it.; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126, Italy. vincenzo.calautti@unito.it.

Publikováno v: Molecular cancer [Mol Cancer] 2024 May 16; Vol. 23 (1), pp. 105. Date of Electronic Publication: 2024 May 16.

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Chronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma.

Autor: Fiorilla I; Department of Science and Technological Innovation (DISIT), University of Eastern Piedmont, 15121 Alessandria, Italy.; Department of Integrated Activities Research and Innovation (DAIRI), Public Hospital Azienda Ospedaliera 'SS. Antonio e Biagio e Cesare Arrigo', 15121 Alessandria, Italy., Martinotti S; Department of Science and Technological Innovation (DISIT), University of Eastern Piedmont, 15121 Alessandria, Italy.; Department of Integrated Activities Research and Innovation (DAIRI), Public Hospital Azienda Ospedaliera 'SS. Antonio e Biagio e Cesare Arrigo', 15121 Alessandria, Italy., Todesco AM; Department of Science and Technological Innovation (DISIT), University of Eastern Piedmont, 15121 Alessandria, Italy.; Department of Integrated Activities Research and Innovation (DAIRI), Public Hospital Azienda Ospedaliera 'SS. Antonio e Biagio e Cesare Arrigo', 15121 Alessandria, Italy., Bonsignore G; Department of Science and Technological Innovation (DISIT), University of Eastern Piedmont, 15121 Alessandria, Italy.; Department of Integrated Activities Research and Innovation (DAIRI), Public Hospital Azienda Ospedaliera 'SS. Antonio e Biagio e Cesare Arrigo', 15121 Alessandria, Italy., Cavaletto M; Department for Sustainable Development and Ecological Transition (DISSTE), University of Eastern Piedmont, 13100 Vercelli, Italy., Patrone M; Department of Science and Technological Innovation (DISIT), University of Eastern Piedmont, 15121 Alessandria, Italy.; Department of Integrated Activities Research and Innovation (DAIRI), Public Hospital Azienda Ospedaliera 'SS. Antonio e Biagio e Cesare Arrigo', 15121 Alessandria, Italy., Ranzato E; Department of Science and Technological Innovation (DISIT), University of Eastern Piedmont, 15121 Alessandria, Italy.; Department of Integrated Activities Research and Innovation (DAIRI), Public Hospital Azienda Ospedaliera 'SS. Antonio e Biagio e Cesare Arrigo', 15121 Alessandria, Italy., Audrito V; Department of Science and Technological Innovation (DISIT), University of Eastern Piedmont, 15121 Alessandria, Italy.; Department of Integrated Activities Research and Innovation (DAIRI), Public Hospital Azienda Ospedaliera 'SS. Antonio e Biagio e Cesare Arrigo', 15121 Alessandria, Italy.

Publikováno v: Cells [Cells] 2023 Aug 11; Vol. 12 (16). Date of Electronic Publication: 2023 Aug 11.

Inhibition of NAMPT by PAK4 Inhibitors.

Autor: Wang, Yiling¹ (AUTHOR) yw798@scarletmail.rutgers.edu, Minden, Audrey¹ (AUTHOR) aminden@pharmacy.rutgers.edu

Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p10138. 15p.