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Celiac Disease Histopathology Recapitulates Hedgehog Downregulation, Consistent with Wound Healing Processes Activation

Autor: Maria Fiorentino, Gregory Y. Lauwers, Giuseppe Mazzarella, Anna Sapone, Alessio Fasano, Stefania Senger

Publikováno v: PLoS ONE
PloS one 10 (2015): 1–15. doi:10.1371/journal.pone.0144634
info:cnr-pdr/source/autori:Senger, Stefania; Sapone, Anna; Sapone, Anna; Fiorentino, Maria Rosaria; Mazzarella, Giuseppe; Lauwers, Gregory Y.; Fasano, Alessio/titolo:Celiac disease histopathology recapitulates hedgehog downregulation, consistent with wound healing processes activation/doi:10.1371%2Fjournal.pone.0144634/rivista:PloS one/anno:2015/pagina_da:1/pagina_a:15/intervallo_pagine:1–15/volume:10
PLoS ONE, Vol 10, Iss 12, p e0144634 (2015)

BACKGROUND:In celiac disease (CD), intestinal epithelium damage occurs secondary to an immune insult and is characterized by blunting of the villi and crypt hyperplasia. Similarities between Hedgehog (Hh)/BMP4 downregulation, as reported in a mouse m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6c551fd415db8498f0219d8c4de2d6
https://doi.org/10.1371/journal.pone.0144634