Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Fiorella Di Pastena"'
Autor:
Lindsay A. Broadfield, Amna Saigal, Jake C. Szamosi, Joanne A. Hammill, Ksenia Bezverbnaya, Dongdong Wang, Jaya Gautam, Evangelia E. Tsakiridis, Fiorella Di Pastena, Jamie McNicol, Jianhan Wu, Saad Syed, James S.V. Lally, Amogelang R. Raphenya, Marie-Jose Blouin, Michael Pollak, Andrea Sacconi, Giovanni Blandino, Andrew G. McArthur, Jonathan D. Schertzer, Michael G. Surette, Stephen M. Collins, Jonathan L. Bramson, Paola Muti, Theodoros Tsakiridis, Gregory R. Steinberg
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101498- (2022)
Background/Purpose: Type 2 diabetes and obesity increase the risk of developing colorectal cancer. Metformin may reduce colorectal cancer but the mechanisms mediating this effect remain unclear. In mice and humans, a high-fat diet (HFD), obesity and
Externí odkaz:
https://doaj.org/article/9fae3275a0774580a7ba65a044f50126
Autor:
Laura Di Magno, Simona Manni, Fiorella Di Pastena, Sonia Coni, Alberto Macone, Sara Cairoli, Manolo Sambucci, Paola Infante, Marta Moretti, Marialaura Petroni, Carmine Nicoletti, Carlo Capalbo, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Luca Battistini, Bianca Maria Goffredo, Egidio Iorio, Enzo Agostinelli, Marella Maroder, Gianluca Canettieri
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1735-1752.e7 (2020)
Summary: The antidiabetic drug phenformin displays potent anticancer activity in different tumors, but its mechanism of action remains elusive. Using Shh medulloblastoma as model, we show here that at clinically relevant concentrations, phenformin el
Externí odkaz:
https://doaj.org/article/598bceb7f2be4008945d9487d0404b2f
Publikováno v:
Cancers. 14(13)
Biguanides are a family of antidiabetic drugs with documented anticancer properties in preclinical and clinical settings. Despite intensive investigation, how they exert their therapeutic effects is still debated. Many studies support the hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4009eb8853390fd1fc07f1d0f1ad2e
https://pubmed.ncbi.nlm.nih.gov/35804992
https://pubmed.ncbi.nlm.nih.gov/35804992
Autor:
Laura Di Magno, Antonio Coluccia, Marianna Bufano, Silvia Ripa, Giuseppe La Regina, Marianna Nalli, Fiorella Di Pastena, Gianluca Canettieri, Romano Silvestri, Luigi Frati
Publikováno v:
European journal of medicinal chemistry. 240
Most cancer cells switch their metabolism from mitochondrial oxidative phosphorylation to aerobic glycolysis to generate ATP and precursors for the biosynthesis of key macromolecules. The aerobic conversion of pyruvate to lactate, coupled to oxidatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee07bddfe4bca0d30e09bf72c329ffcb
https://pubmed.ncbi.nlm.nih.gov/35868126
https://pubmed.ncbi.nlm.nih.gov/35868126
Sulfonamide inhibitors of beta-catenin signaling as anticancer agents with different output on c-Myc
Autor:
Alessia Ciogli, Laura Di Magno, Romano Silvestri, Fiorella Di Pastena, Antonio Coluccia, Giuseppe La Regina, Simone Manetto, Marianna Nalli, Marella Maroder, Michela Puxeddu, Gianluca Canettieri
The Wnt/β-catenin pathway is often found deregulated in cancer. The aberrant accumulation of β-catenin in the cell nucleus results in the development of various malignancies. Specific drugs against this signaling pathway for clinical treatments hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6306e7638f038246e91749adcf677e2
http://hdl.handle.net/11573/1451071
http://hdl.handle.net/11573/1451071
Autor:
Marialaura Petroni, Laura Antonucci, John R. Yates, Carlo Capalbo, Enrico De Smaele, Sonia Coni, Fiorella Di Pastena, Maria Eugenia Schininà, Laura Di Magno, Miriam Caimano, Silvia Maria Serrao, Rosa Bordone, Saula Checquolo, Zuleyha Nihan Yurtsever, Alessandra Giorgi, Simona Manni, Enzo Agostinelli, Lucia Di Marcotullio, Gianluca Canettieri, Davide D'Amico, Marella Maroder
Publikováno v:
International Journal of Oncology
The aberrant activation of hedgehog (HH) signaling is a leading cause of the development of medulloblastoma, a pediatric tumor of the cerebellum. The FDA‑approved HH inhibitor, Vismodegib, which targets the transmembrane transducer SMO, has shown l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca187f4be9ac6c12b91039e8c12d7c6
https://doi.org/10.3892/ijo.2018.4638
https://doi.org/10.3892/ijo.2018.4638
Autor:
Viviana Orlando, Marta Baiocchi, Maria Laura De Angelis, Romano Silvestri, Giuseppe La Regina, Stefano Biagioni, Candice Gautier, Valentina Naccarato, Gianluca Canettieri, Laura Di Magno, Antonio Coluccia, Stefano Gianni, Fiorella Di Pastena, Addolorata Coluccia, Marianna Nalli
Publikováno v:
ACS Medicinal Chemistry Letters
Targeted approaches aiming at modulating NHERF1 activity, rather than its overall expression, would be preferred to preserve the normal functions of this versatile protein. We focused our attention on the NHERF1/PDZ1 domain that governs its membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd24a8010546bbb3bab53c4ce48e7636
https://pubmed.ncbi.nlm.nih.gov/30996786
https://pubmed.ncbi.nlm.nih.gov/30996786