Ranking strategies to support toxicity prediction: a case study on potential lxr binders

Autor: Palczewska, Anna Maria, Kovarich, S., Ciacci, A., Fioravanzo, E., Bassan, A., Neagu, Daniel

Yes
The current paradigm of toxicity testing is set within a framework of Mode-of-Action (MoA)/Adverse Outcome Pathway (AOP) investigations, where novel methodologies alternative to animal testing play a crucial role, and allow to consider causa

Externí odkaz: http://hdl.handle.net/10454/16786

Assessment of the Intestinal Absorption of Higher Olefins by the Everted Gut Sac Model in Combination with In Silico New Approach Methodologies.

Autor: Shi Q; Shell Global Solutions International B.V., Carel van Bylandtlaan 16, The Hague 2596HR, The Netherlands., Carrillo JC; Shell Global Solutions International B.V., Carel van Bylandtlaan 16, The Hague 2596HR, The Netherlands., Penman MG; Penman Consulting Ltd., Aspect House, Grove Business Park, Grove, Wantage, Oxon OX12 9FF, U.K., Manton J; Penman Consulting Ltd., Aspect House, Grove Business Park, Grove, Wantage, Oxon OX12 9FF, U.K., Fioravanzo E; ToxNavigation Ltd., Mole View, 158 Bridge Road, East Molesey KT9 8HW, U.K., Powrie RH; CXR Biosciences Ltd., 2 James Lindsay Place, Dundee Technopole, Dundee DD1 5JJ, U.K., Elcombe CR; CXR Biosciences Ltd., 2 James Lindsay Place, Dundee Technopole, Dundee DD1 5JJ, U.K., Borsboom-Patel T; Penman Consulting Ltd., Aspect House, Grove Business Park, Grove, Wantage, Oxon OX12 9FF, U.K., Tian Y; University College London, 11-43 Bath Street, London EC1V 9EL, U.K., Shen H; Shell Oil Company, 150 N. Dairy Ashford Road, Houston, Texas 77079, United States., Boogaard PJ; Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands.

Publikováno v: Chemical research in toxicology [Chem Res Toxicol] 2022 Aug 15; Vol. 35 (8), pp. 1383-1392. Date of Electronic Publication: 2022 Jul 13.

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Evaluation of the applicability of existing (Q)SAR models for predicting the genotoxicity of pesticides and similarity analysis related with genotoxicity of pesticides for facilitating of grouping and read across: An EFSA funded project.

Autor: Benigni R; Alpha-Pretox, Rome, Italy. Electronic address: romualdo.benigni@gmail.com., Serafimova R; European Food Safety Authority, Parma, Italy., Parra Morte JM; European Food Safety Authority, Parma, Italy., Battistelli CL; Istituto Superiore di Sanità (ISS), Environmental and Health Department, Rome, Italy., Bossa C; Istituto Superiore di Sanità (ISS), Environmental and Health Department, Rome, Italy., Giuliani A; Istituto Superiore di Sanità (ISS), Environmental and Health Department, Rome, Italy., Fioravanzo E; S-IN Soluzioni Informatiche Srl, Vicenza, Italy., Bassan A; S-IN Soluzioni Informatiche Srl, Vicenza, Italy., Gatnik MF; S-IN Soluzioni Informatiche Srl, Vicenza, Italy., Rathman J; Altamira, LLC, USA., Yang C; Altamira, LLC, USA., Mostrag-Szlichtyng A; Altamira, LLC, USA., Sacher O; Altamira, LLC, USA., Tcheremenskaia O; Istituto Superiore di Sanità (ISS), Environmental and Health Department, Rome, Italy.

Publikováno v: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Jul; Vol. 114, pp. 104658. Date of Electronic Publication: 2020 Apr 22.

Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study.

Autor: Ortega-Vallbona, Rita¹ (AUTHOR) rortega@protoqsar.com, Palomino-Schätzlein, Martina¹ (AUTHOR) mpalomino@protoqsar.com, Tolosa, Laia^2,3 (AUTHOR) laia_tolosa@iislafe.es, Benfenati, Emilio⁴ (AUTHOR) emilio.benfenati@marionegri.it, Ecker, Gerhard F.⁵ (AUTHOR) gerhard.f.ecker@univie.ac.at, Gozalbes, Rafael^1,6 (AUTHOR) rgozalbes@protoqsar.com, Serrano-Candelas, Eva¹ (AUTHOR) eserrano@protoqsar.com

Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 20, p11154. 40p.