Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation

Autor: Wang, Zhenxing, D'Annessa, Ilda, Tesauro, Cinzia, Croce, Stefano, Ottaviani, Alessio, Fiorani, Paola, Desideri, Alessandro

Publikováno v: In BBA - Proteins and Proteomics August 2015 1854(8):860-868

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Swapping of The N-Terminal Domain of Human Topoisomerase 1B with the Corresponding Plasmodium Falciparum Counterpart Strongly Impairs Enzyme Activity

Autor: Dasari, Jagadish Babu, Soren, Bini Chhetri, Ottaviani, Alessio, Tesauro, Cinzia, Marino, Simona, Messina, Beatrice, Fiorani, Paola

Publikováno v: BMB Reports (Online) 8 (2020): 366–375.
info:cnr-pdr/source/autori:Dasari, Jagadish Babu; Soren, Bini Chhetri; Ottaviani, Alessio; Tesauro, Cinzia; Marino, Simona; Messina, Beatrice; Fiorani, Paola/titolo:Swapping of The N-Terminal Domain of Human Topoisomerase 1B with the Corresponding Plasmodium Falciparum Counterpart Strongly Impairs Enzyme Activity/doi:/rivista:BMB Reports (Online)/anno:2020/pagina_da:366/pagina_a:375/intervallo_pagine:366–375/volume:8
Dasari, J B, Soren, B C, Ottaviani, A, Tesauro, C, Marino, S, Messina, B & Fiorani, P 2020, ' Swapping of The N-Terminal Domain of Human Topoisomerase 1B with the Corresponding Plasmodium Falciparum Counterpart Strongly Impairs Enzyme Activity ', Reports of Biochemistry and Molecular Biology, vol. 8, no. 4, pp. 366-375 . < https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275839/ >
Rep Biochem Mol Biol

Background:DNA topoisomerases 1B are a class of ubiquitous enzyme that solves the topological problems associated with biological processes such as replication, transcription and recombination. Numerous sequence alignment of topoisomerase 1B from dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1a38516ff6f8df4335089a285c0fb1c0
https://publications.cnr.it/doc/432182