Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Fiona Watkinson"'
Publikováno v:
BMC Health Services Research, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background The need for information exchange and integrated care has stimulated the development of interoperability solutions that bring together patient data across the health and care system to enable effective information sharing. Health
Externí odkaz:
https://doaj.org/article/81c8a0e1486b4b9998d40e45eeec7863
Autor:
Fiona Watkinson, Sandeep Krishan Nayar, Aradhana Rani, Christina A. Sakellariou, Oussama Elhage, Efthymia Papaevangelou, Prokar Dasgupta, Christine Galustian
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Interleukin-15 (IL-15) is a cytokine that has been shown to expand CD8 T cell and natural killer (NK) cell populations, and therefore has potential for potentiating adoptive immune cell therapy for cancer. Previously, IL-15 has been shown to induce p
Externí odkaz:
https://doaj.org/article/fb80361ec207455db22d79483fa9bd01
Autor:
Anne-Florence Blandin, Ross Giglio, Maya Srikanth Graham, Guadalupe Garcia, Seth Malinowski, Jared K. Woods, Shakti Ramkissoon, Lori Ramkissoon, Frank Dubois, Kathleen Schoolcraft, Jessica Tsai, Dayle Wang, Robert Jones, Jayne Vogelzang, Kristine Pelton, Sarah Becker, Fiona Watkinson, Claire Sinai, Elizabeth F. Cohen, Matthew A. Booker, Michael Y. Tolstorukov, Veerle Haemels, Liliana Goumnerova, Karen Wright, Mark Kieran, Katie Fehnel, David Reardon, Arnault Tauziede-Espariat, Rishi Lulla, Benjamin Carcamo, Stanley Chaleff, Alain Charest, Frederik De Smet, Azra H. Ligon, Adrian Dubuc, Melanie Pages, Pascale Varlet, Patrick Y. Wen, Brian M. Alexander, Susan Chi, Sanda Alexandrescu, Ralf Kittler, Robert Bachoo, Pratiti Bandopadhayay, Rameen Beroukhim, Keith L. Ligon
Publikováno v:
Clinical Cancer Research. :OF1-OF17
Purpose: Anaplastic lymphoma kinase (ALK) aberrations have been identified in pediatric-type infant gliomas, but their occurrence across age groups, functional effects, and treatment response has not been broadly established. Experimental Design: We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::284b9c146f0dfa3d1d6edc1c4f96c9f1
https://doi.org/10.1158/1078-0432.ccr-21-3521
https://doi.org/10.1158/1078-0432.ccr-21-3521
Autor:
Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay, Robert Bachoo, Ralf Kittler, Sanda Alexandrescu, Susan Chi, Brian M. Alexander, Patrick Y. Wen, Pascale Varlet, Melanie Pages, Adrian Dubuc, Azra H. Ligon, Frederik De Smet, Alain Charest, Stanley Chaleff, Benjamin Carcamo, Rishi Lulla, Arnault Tauziede-Espariat, David Reardon, Katie Fehnel, Mark Kieran, Karen Wright, Liliana Goumnerova, Veerle Haemels, Michael Y. Tolstorukov, Matthew A. Booker, Elizabeth F. Cohen, Claire Sinai, Fiona Watkinson, Sarah Becker, Kristine Pelton, Jayne Vogelzang, Robert Jones, Dayle Wang, Jessica Tsai, Kathleen Schoolcraft, Frank Dubois, Lori Ramkissoon, Shakti Ramkissoon, Jared K. Woods, Seth Malinowski, Guadalupe Garcia, Maya Srikanth Graham, Ross Giglio, Anne-Florence Blandin
Supplementary Figure 3: PPP1CB-ALK fusion is oncogenic and sensitive to targeted therapy. A. Immunoblot analysis of ALK downstream signaling proteins in cortical mNSC (CTX#6) and brainstem mNSC (BS#3) expressing PPP1CB-ALK. Cells were treated for 4 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6f55cc812f188c30f166cd96a721a2
https://doi.org/10.1158/1078-0432.22490657
https://doi.org/10.1158/1078-0432.22490657
Autor:
Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay, Robert Bachoo, Ralf Kittler, Sanda Alexandrescu, Susan Chi, Brian M. Alexander, Patrick Y. Wen, Pascale Varlet, Melanie Pages, Adrian Dubuc, Azra H. Ligon, Frederik De Smet, Alain Charest, Stanley Chaleff, Benjamin Carcamo, Rishi Lulla, Arnault Tauziede-Espariat, David Reardon, Katie Fehnel, Mark Kieran, Karen Wright, Liliana Goumnerova, Veerle Haemels, Michael Y. Tolstorukov, Matthew A. Booker, Elizabeth F. Cohen, Claire Sinai, Fiona Watkinson, Sarah Becker, Kristine Pelton, Jayne Vogelzang, Robert Jones, Dayle Wang, Jessica Tsai, Kathleen Schoolcraft, Frank Dubois, Lori Ramkissoon, Shakti Ramkissoon, Jared K. Woods, Seth Malinowski, Guadalupe Garcia, Maya Srikanth Graham, Ross Giglio, Anne-Florence Blandin
Supplementary Figure 5: Single-cell RNA Sequencing and IHC examination of ALK in human neural development and immature neural cells. A. 2D representation of human brain cell subtypes (48 samples) during cortex development using a single cell RNA-seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67179e7baac4cc1baaf982962c9e364e
https://doi.org/10.1158/1078-0432.22490648
https://doi.org/10.1158/1078-0432.22490648
Autor:
Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay, Robert Bachoo, Ralf Kittler, Sanda Alexandrescu, Susan Chi, Brian M. Alexander, Patrick Y. Wen, Pascale Varlet, Melanie Pages, Adrian Dubuc, Azra H. Ligon, Frederik De Smet, Alain Charest, Stanley Chaleff, Benjamin Carcamo, Rishi Lulla, Arnault Tauziede-Espariat, David Reardon, Katie Fehnel, Mark Kieran, Karen Wright, Liliana Goumnerova, Veerle Haemels, Michael Y. Tolstorukov, Matthew A. Booker, Elizabeth F. Cohen, Claire Sinai, Fiona Watkinson, Sarah Becker, Kristine Pelton, Jayne Vogelzang, Robert Jones, Dayle Wang, Jessica Tsai, Kathleen Schoolcraft, Frank Dubois, Lori Ramkissoon, Shakti Ramkissoon, Jared K. Woods, Seth Malinowski, Guadalupe Garcia, Maya Srikanth Graham, Ross Giglio, Anne-Florence Blandin
Purpose:Anaplastic lymphoma kinase (ALK) aberrations have been identified in pediatric-type infant gliomas, but their occurrence across age groups, functional effects, and treatment response has not been broadly established.Experimental Design:We per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6831c03b61aab5d2915a36779f74d458
https://doi.org/10.1158/1078-0432.c.6533192
https://doi.org/10.1158/1078-0432.c.6533192
Autor:
Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay, Robert Bachoo, Ralf Kittler, Sanda Alexandrescu, Susan Chi, Brian M. Alexander, Patrick Y. Wen, Pascale Varlet, Melanie Pages, Adrian Dubuc, Azra H. Ligon, Frederik De Smet, Alain Charest, Stanley Chaleff, Benjamin Carcamo, Rishi Lulla, Arnault Tauziede-Espariat, David Reardon, Katie Fehnel, Mark Kieran, Karen Wright, Liliana Goumnerova, Veerle Haemels, Michael Y. Tolstorukov, Matthew A. Booker, Elizabeth F. Cohen, Claire Sinai, Fiona Watkinson, Sarah Becker, Kristine Pelton, Jayne Vogelzang, Robert Jones, Dayle Wang, Jessica Tsai, Kathleen Schoolcraft, Frank Dubois, Lori Ramkissoon, Shakti Ramkissoon, Jared K. Woods, Seth Malinowski, Guadalupe Garcia, Maya Srikanth Graham, Ross Giglio, Anne-Florence Blandin
Supplementary Figure 6: Single cell RNA sequencing comparison of ALK expression and other infant/pediatric glioma kinase drivers in developing human and mouse brain. A. 2D representation of human brain cell subtypes (48 samples) during cortex develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052cc7ad69f098b9b0e8156c7ea879e9
https://doi.org/10.1158/1078-0432.22490645
https://doi.org/10.1158/1078-0432.22490645
Autor:
Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay, Robert Bachoo, Ralf Kittler, Sanda Alexandrescu, Susan Chi, Brian M. Alexander, Patrick Y. Wen, Pascale Varlet, Melanie Pages, Adrian Dubuc, Azra H. Ligon, Frederik De Smet, Alain Charest, Stanley Chaleff, Benjamin Carcamo, Rishi Lulla, Arnault Tauziede-Espariat, David Reardon, Katie Fehnel, Mark Kieran, Karen Wright, Liliana Goumnerova, Veerle Haemels, Michael Y. Tolstorukov, Matthew A. Booker, Elizabeth F. Cohen, Claire Sinai, Fiona Watkinson, Sarah Becker, Kristine Pelton, Jayne Vogelzang, Robert Jones, Dayle Wang, Jessica Tsai, Kathleen Schoolcraft, Frank Dubois, Lori Ramkissoon, Shakti Ramkissoon, Jared K. Woods, Seth Malinowski, Guadalupe Garcia, Maya Srikanth Graham, Ross Giglio, Anne-Florence Blandin
Supplementary Figure 2: T1 post-contrast axial and sagittal images of ALK-fused and non ALK-altered GBMs and ALK staining in ALK-fused congenital GBMs. A. Example images from patients with ALK aberrations (76, 89, 116, 197)B. In contrast to those wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001d86753428b01e252c6450d0b0f7d9
https://doi.org/10.1158/1078-0432.22490660.v1
https://doi.org/10.1158/1078-0432.22490660.v1
Autor:
Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay, Robert Bachoo, Ralf Kittler, Sanda Alexandrescu, Susan Chi, Brian M. Alexander, Patrick Y. Wen, Pascale Varlet, Melanie Pages, Adrian Dubuc, Azra H. Ligon, Frederik De Smet, Alain Charest, Stanley Chaleff, Benjamin Carcamo, Rishi Lulla, Arnault Tauziede-Espariat, David Reardon, Katie Fehnel, Mark Kieran, Karen Wright, Liliana Goumnerova, Veerle Haemels, Michael Y. Tolstorukov, Matthew A. Booker, Elizabeth F. Cohen, Claire Sinai, Fiona Watkinson, Sarah Becker, Kristine Pelton, Jayne Vogelzang, Robert Jones, Dayle Wang, Jessica Tsai, Kathleen Schoolcraft, Frank Dubois, Lori Ramkissoon, Shakti Ramkissoon, Jared K. Woods, Seth Malinowski, Guadalupe Garcia, Maya Srikanth Graham, Ross Giglio, Anne-Florence Blandin
Supplementary Figure 4: Characterization of the lung cancer recurrent DCTN1-ALK fusion identified in cGBM (case ALK.232). A. Integrative Genomic Viewer (IGV) screenshot of the DCTN1-ALK variant.B. Predicted sequence of DCTN1-ALK fusion (DCTN1 exon 1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2e316fd70c9ce1bfcee31d38ce4060
https://doi.org/10.1158/1078-0432.22490654.v1
https://doi.org/10.1158/1078-0432.22490654.v1
Autor:
Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay, Robert Bachoo, Ralf Kittler, Sanda Alexandrescu, Susan Chi, Brian M. Alexander, Patrick Y. Wen, Pascale Varlet, Melanie Pages, Adrian Dubuc, Azra H. Ligon, Frederik De Smet, Alain Charest, Stanley Chaleff, Benjamin Carcamo, Rishi Lulla, Arnault Tauziede-Espariat, David Reardon, Katie Fehnel, Mark Kieran, Karen Wright, Liliana Goumnerova, Veerle Haemels, Michael Y. Tolstorukov, Matthew A. Booker, Elizabeth F. Cohen, Claire Sinai, Fiona Watkinson, Sarah Becker, Kristine Pelton, Jayne Vogelzang, Robert Jones, Dayle Wang, Jessica Tsai, Kathleen Schoolcraft, Frank Dubois, Lori Ramkissoon, Shakti Ramkissoon, Jared K. Woods, Seth Malinowski, Guadalupe Garcia, Maya Srikanth Graham, Ross Giglio, Anne-Florence Blandin
Supplementary Figure 1: Characterization of the novel LRRFIP1-ALK fusion (case ALK.223) A. Visualization of the read coverage at the fusion sites in ALK and LRRFIP1 genes using Integrative Genomic Viewer.B. Pile-up plot generated by SvABA using whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f603f2b1bbb08d61cede2c679cc86ed
https://doi.org/10.1158/1078-0432.22490663
https://doi.org/10.1158/1078-0432.22490663