Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Fiona V Cresswell"'
Autor:
Abigail R. Gress, Christine E. Ronayne, Joshua M. Thiede, David K. Meyerholz, Samuel Okurut, Julia Stumpf, Tailor V. Mathes, Kenneth Ssebambulidde, David B. Meya, Fiona V. Cresswell, David R. Boulware, Tyler D. Bold
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract After Mycobacterium tuberculosis (Mtb) infection, many effector T cells traffic to the lungs, but few become activated. Here we use an antigen receptor reporter mouse (Nur77-GFP) to identify recently activated CD4 T cells in the lungs. These
Externí odkaz:
https://doaj.org/article/ca259876e3be47d9b437b62b4a3c7cd7
Autor:
Caleb P. Skipper, Katherine Huppler Hullsiek, Fiona V. Cresswell, Kiiza K. Tadeo, Michael Okirwoth, Mark Blackstad, Nelmary Hernandez-Alvarado, Claudia Fernández-Alarcón, Stewart Walukaga, Emily Martyn, Jayne Ellis, Kenneth Ssebambulidde, Lillian Tugume, Edwin Nuwagira, Joshua Rhein, David B. Meya, David R. Boulware, Mark R. Schleiss
Publikováno v:
International Journal of Infectious Diseases, Vol 122, Iss , Pp 785-792 (2022)
Objectives: CMV viremia is associated with increased mortality in persons with HIV. We previously demonstrated that CMV viremia was a risk factor for 10-week mortality in antiretroviral therapy (ART)-naïve persons with cryptococcal meningitis. We in
Externí odkaz:
https://doaj.org/article/b0a922ef9fe944e9a2f7fe858d771042
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Diagnosis of tuberculous meningitis (TBM) remains challenging due to a paucity of high-performance diagnostics. Even those that have reasonable sensitivity are not adequate to ‘rule out' TBM. Therefore, a combination of clinical factors alongside m
Externí odkaz:
https://doaj.org/article/94bb15bf4650479a8a00434bacf907f0
Autor:
David B Meya, Alison Elliott, David R Boulware, Fiona V Cresswell, Carson M Quinn, Mable Kabahubya, Ananta S Bangdiwala, Sarah Lofgren, John Kasibante, Alice Namudde, Noeline Nakasujja
Publikováno v:
Wellcome Open Research, Vol 6 (2022)
Background: The toll of tuberculous meningitis (TBM) in both mortality and disability is considerable, but advancements in rehabilitation have the potential to improve the functional abilities and the quality of survivors’ lives. However, the typic
Externí odkaz:
https://doaj.org/article/3db25ef226384aa69b56f383b04dd308
Autor:
Nathan C Bahr, Fiona V Cresswell, Nguyen Thuy Thuong Thuong, Rachel P.J. Lai, Angharad G. Davis, David R Boulware, Robert J Wilkinson, Johan Schoeman, Marise Bremer, Joseph Donovan, Ronald Van Toorn, Guy E Thwaites, Ariba Dadabhoy
Publikováno v:
Wellcome Open Research, Vol 5 (2021)
A dysregulated host immune response significantly contributes to morbidity and mortality in tuberculous meningitis (TBM). Effective host directed therapies (HDTs) are critical to improve survival and clinical outcomes. Currently only one HDT, dexamet
Externí odkaz:
https://doaj.org/article/1082f9028b78463baff862754b13c9a1
Autor:
Gavin A. Stead, Fiona V. Cresswell, Samuel Jjunju, Pham K.N. Oanh, Guy E. Thwaites, Joseph Donovan
Publikováno v:
eNeurologicalSci, Vol 23, Iss , Pp 100330- (2021)
Brain infections cause significant morbidity and mortality worldwide, especially in resource-limited settings with high HIV co-infection rates. Raised intracranial pressure [ICP] may complicate brain infection and worsen neurological injury, yet inva
Externí odkaz:
https://doaj.org/article/642dc498cab6419cb47ec2958d2602e9
Autor:
Peter J Dodd, Muhammad Osman, Fiona V Cresswell, Anna M Stadelman, Nguyen Huu Lan, Nguyen Thuy Thuong Thuong, Morris Muzyamba, Lisa Glaser, Sicelo S Dlamini, James A Seddon
Publikováno v:
PLOS Global Public Health, Vol 1, Iss 12, p e0000069 (2021)
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis. The incidence and mortality of TBM is unknown due to diagnostic challenges and limited disaggregated reporting of treated TBM by existing surveillance systems. We aimed to estimate
Externí odkaz:
https://doaj.org/article/5e2ac906120a4251bf9ed8535523dcee
Autor:
Fiona V Cresswell, Angharad G. Davis, Kusum Sharma, Robindra Basu Roy, Ahmad Rizal Ganiem, Enock Kagimu, Regan Solomons, Robert J. Wilkinson, Nathan C Bahr, Nguyen Thuy Thuong Thuong, Tuberculous Meningitis International Research Consortium
Publikováno v:
Wellcome Open Research, Vol 4 (2021)
The pathogenesis of Tuberculous meningitis (TBM) is poorly understood, but contemporary molecular biology technologies have allowed for recent improvements in our understanding of TBM. For instance, neutrophils appear to play a significant role in th
Externí odkaz:
https://doaj.org/article/04e368a4097b43cda1a7ffab7f4734cf
Autor:
Tom Boyles, Anna Stadelman, Jayne P. Ellis, Fiona V. Cresswell, Vittoria Lutje, Sean Wasserman, Nicki Tiffin, Robert Wilkinson
Publikováno v:
Wellcome Open Research, Vol 4 (2021)
Background: Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis. Delayed diagnosis and treatment, which is a risk factor for poor outcome, is caused in part by lack of availability of diagnostic tests that are both rapi
Externí odkaz:
https://doaj.org/article/b862774b996b4eb3b3f72f5c97c39fe1
Autor:
Fiona V. Cresswell, John Kasibante, Emily M. Martyn, Lillian Tugume, Gavin Stead, Kenneth Ssembambulidde, Morris K. Rutakingirwa, Enock Kagimu, Laura Nsangi, Carol Namuju, Jane F. Ndyetukira, Cynthia Ahimbisibwe, Florence Kugonza, Alisat Sadiq, Alice Namudde, Joanna Dobbin, Diksha Srishyla, Carson Quinn, Mable Kabahubya, Conrad Muzoora, Stephen Watiti, David B. Meya, Alison M. Elliott
Publikováno v:
AAS Open Research, Vol 3 (2020)
Over the last decade excellent progress has been made globally in HIV management thanks to antiretroviral therapy (ART) rollout and international guidelines now recommending immediate initiation of ART in people living with HIV. Despite this, advance
Externí odkaz:
https://doaj.org/article/412ad244760b4a38a2908642cf6d1f8d