Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Fiona Spreitzer"'
Autor:
Thomas Hoffmann, Alexandra Hörmann, Maja Corcokovic, Jakub Zmajkovic, Matthias Hinterndorfer, Jasko Salkanovic, Fiona Spreitzer, Anna Köferle, Katrin Gitschtaler, Alexandra Popa, Sarah Oberndorfer, Florian Andersch, Markus Schaefer, Michaela Fellner, Nicole Budano, Jan G Ruppert, Paolo Chetta, Melanie Wurm, Johannes Zuber, Ralph A Neumüller
Publikováno v:
eLife, Vol 12 (2023)
Loss-of-function genetic tools are widely applied for validating therapeutic targets, but their utility remains limited by incomplete on- and uncontrolled off-target effects. We describe artificial RNA interference (ARTi) based on synthetic, ultra-po
Externí odkaz:
https://doaj.org/article/5be3978b927a49d695b800fdcd6cb2bb
Autor:
Fiona Spreitzer, Corinna Wieshofer, Barbara Mair, Alexandra Popa, Christoph Reiser, Alexandra Hörmann, Andreas Schlattl, Sarah Oberndorfer, Venu Thatikonda, Anna Köferle, Ralph A. Neumüller, Teresa Puchner, Mark Pearson, Simon Wöhrle, Maja Corcokovic, Johannes Popow
Genetic networks are characterized by extensive buffering. During tumour evolution, disruption of these functional redundancies can create de novo vulnerabilities that are specific to cancer cells. In this regard, paralog genes are of particular inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1227f1a8fc42b44d97b2ca782bbe5f05
https://doi.org/10.1101/2021.05.21.445116
https://doi.org/10.1101/2021.05.21.445116
Autor:
Anna Köferle, Andreas Schlattl, Alexandra Hörmann, Fiona Spreitzer, Alexandra Popa, Venu Thatikonda, Teresa Puchner, Verena Supper, Madhwesh C. Ravichandran, Sarah Oberndorfer, Corinna Wieshofer, Maja Corcokovic, Christoph Reiser, Simon Wöhrle, Johannes Popow, Mark Pearson, Barbara Mair, Ralph A. Neumüller
Publikováno v:
Cancer Research. 82:4004-4004
Genetic networks are characterized by extensive buffering. During tumor evolution, disruption of these functional redundancies can create de novo vulnerabilities that are specific to cancer cells. In this regard, paralog genes are of particular inter
Autor:
Anna Köferle, Andreas Schlattl, Alexandra Hörmann, Venu Thatikonda, Alexandra Popa, Fiona Spreitzer, Madhwesh C. Ravichandran, Verena Supper, Sarah Oberndorfer, Teresa Puchner, Corinna Wieshofer, Maja Corcokovic, Christoph Reiser, Simon Wöhrle, Johannes Popow, Mark Pearson, Javier Martinez, Stefan Weitzer, Barbara Mair, Ralph A. Neumüller
Publikováno v:
Cell Reports. 39:110636
Genetic networks are characterized by extensive buffering. During tumor evolution, disruption of functional redundancies can create de novo vulnerabilities that are specific to cancer cells. Here, we systematically search for cancer-relevant paralog