Correction: Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.

Autor: Fiona Semple, Heather MacPherson, Sheila Webb, Fiona Kilanowski, Laura Lettice, Sarah L McGlasson, Ann P Wheeler, Valerie Chen, Glenn L Millhauser, Lauren Melrose, Donald J Davidson, Julia R Dorin

Publikováno v: PLoS Genetics, Vol 12, Iss 1, p e1005801 (2016)

[This corrects the article DOI: 10.1371/journal.pgen.1005673.].

Externí odkaz: https://doaj.org/article/22629890b1184e4cb180d81aabec403d

Partial deletion of chromosome 8 β-defensin cluster confers sperm dysfunction and infertility in male mice.

Autor: Yu S Zhou, Sheila Webb, Laura Lettice, Steve Tardif, Fiona Kilanowski, Christine Tyrrell, Heather Macpherson, Fiona Semple, Peter Tennant, Tina Baker, Alan Hart, Paul Devenney, Paul Perry, Tracey Davey, Perdita Barran, Chris L Barratt, Julia R Dorin

Publikováno v: PLoS Genetics, Vol 9, Iss 10, p e1003826 (2013)

β-defensin peptides are a family of antimicrobial peptides present at mucosal surfaces, with the main site of expression under normal conditions in the male reproductive tract. Although they kill microbes in vitro and interact with immune cells, the

Externí odkaz: https://doaj.org/article/74a58e02491542409cbfb6b455ff1d15

Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome

Autor: Vera B. Kaiser, Deciphering Developmental Disorders Study, Yatendra Kumar, Lana Talmane, Marie MacLennan, Colin A. Semple, David R. FitzPatrick, Martin S. Taylor, Fiona Semple

Mutation in the germline is the ultimate source of genetic variation, but little is known about the influence of germline chromatin structure on mutational processes. Using ATAC-seq, we profile the open chromatin landscape of human spermatogonia, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f408404b95c84336b84bbcb7e26c126
https://doi.org/10.1101/2021.06.10.447556

Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose

Autor: Stuart J. Forbes, Philip J. Starkey Lewis, Danny Laurent, Elaine Rose, Timothy J. Aitman, Jennifer Coe, James W. Dear, Fiona Semple, Mark J. Arends, Holly A. Black

Publikováno v: BMC Medical Genomics
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-12 (2020)
Laurent, D, Semple, F, Starkey Lewis, P J, Rose, E, Black, H A, Coe, J, Forbes, S J, Arends, M J, Dear, J W & Aitman, T J 2020, ' Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose ', BMC Medical Genomics, vol. 13, 60 (2020) . https://doi.org/10.1186/s12920-020-0705-2

Background Despite the emergence of cell-free DNA (cfDNA) as a clinical biomarker in cancer, the tissue origins of cfDNA in healthy individuals have to date been inferred only by indirect and relative measurement methods, such as tissue-specific meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e290dcabb9a04d91c9d11adcbf445d7e
http://europepmc.org/articles/PMC7133021

Human β-defensin 3 increases the TLR9-dependent response to bacterial DNA

Autor: Sarah L, McGlasson, Fiona, Semple, Heather, MacPherson, Mohini, Gray, Donald J, Davidson, Julia R, Dorin

Publikováno v: European Journal of Immunology

Human β‐defensin 3 (hBD3) is a cationic antimicrobial peptide with potent bactericidal activity in vitro. HBD3 is produced in response to pathogen challenge and can modulate immune responses. The amplified recognition of self‐DNA by human plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53cf76dbb9de41f33fe7b0ea7e439033
https://pubmed.ncbi.nlm.nih.gov/28102569