Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Fiona R. Lucas"'
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1
Autor:
Petra Mäkinen, Heikki Tanila, Tuomas Rauramaa, Hilkka Soininen, Mikko Hiltunen, Ville Leinonen, Sami Gabbouj, Kaisa M.A. Kurkinen, Fanni Haapalinna, Timo Sarajärvi, Laura J. Turner, Teemu Natunen, Mitja I. Kurki, Annakaisa Haapasalo, Jussi Paananen, Mikael Marttinen, Anne M. Koivisto, Fiona R. Lucas
Publikováno v:
Journal of cell science. 129(11)
Dysfunction and loss of synapses are early pathogenic events in Alzheimer's disease. A central step in the generation of toxic amyloid-β (Aβ) peptides is the cleavage of amyloid precursor protein (APP) by β-site APP-cleaving enzyme (BACE1). Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88edb67fea49ee010e9e3b03272e9f9a
https://pubmed.ncbi.nlm.nih.gov/27084579
https://pubmed.ncbi.nlm.nih.gov/27084579
Autor:
Christopher C.J. Miller, Patricia C Salinas, Fiona R Lucas, Uta Wagner, N.G. Irving, Janet Brownlees
Publikováno v:
FEBS letters. 411(2-3)
Tau is a neuronal microtubule-associated protein whose function is modulated by phosphorylation. GSK-3beta is a tau kinase. GSK-3beta is part of the wingless signalling pathway and stimulation by wingless is predicted to down-regulate GSK-3beta activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638ea1d00b564b06543e63d180367f87
http://ora.ox.ac.uk/objects/uuid:3c3e81ab-2a0f-44c4-8aea-f1d6ee51ec94
http://ora.ox.ac.uk/objects/uuid:3c3e81ab-2a0f-44c4-8aea-f1d6ee51ec94