Body mass index and waist circumference in early adulthood are associated with thoracolumbar spine shape at age 60-64: The Medical Research Council National Survey of Health and Development.

Autor: Anastasia V Pavlova, Stella G Muthuri, Rachel Cooper, Fiona R Saunders, Jennifer S Gregory, Rebecca J Barr, Kathryn R Martin, Judith E Adams, Diana Kuh, Rebecca J Hardy, Richard M Aspden

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0197570 (2018)

This study investigated associations between measures of adiposity from age 36 and spine shape at 60-64 years. Thoracolumbar spine shape was characterised using statistical shape modelling on lateral dual-energy x-ray absorptiometry images of the spi

Externí odkaz: https://doaj.org/article/fa23fdb565ed408987df758205e6b5e4

A Genome‐Wide Association Study Meta‐Analysis of Alpha Angle Suggests Cam‐Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults

Autor: Benjamin G. Faber, Monika Frysz, April E. Hartley, Raja Ebsim, Cindy G. Boer, Fiona R. Saunders, Jennifer S. Gregory, Richard M. Aspden, Nicholas C. Harvey, Lorraine Southam, William Giles, Christine L. Le Maitre, J. Mark Wilkinson, Joyce B.J. van Meurs, Eleftheria Zeggini, Timothy Cootes, Claudia Lindner, John P. Kemp, George Davey Smith, Jonathan H. Tobias

Publikováno v: Faber, B G, Frysz, M, Hartley, A E, Ebsim, R, Boer, C G, Saunders, F R, Gregory, J S, Aspden, R M, Harvey, N C, Southam, L, Giles, W, Le Maitre, C L, Wilkinson, J M, van Meurs, J B J, Zeggini, E, Cootes, T, Lindner, C, Kemp, J P, Davey Smith, G & Tobias, J H 2023, ' A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults ', Arthritis & rheumatology (Hoboken, N.J.) . https://doi.org/10.1002/art.42451
Faber, B G, Frysz, M, Hartley, A E, Ebsim, R, Boer, C G, Saunders, F R, Gregory, J S, Aspden, R M, Harvey, N C, Southam, L, Giles, W, Le Maitre, C L, Wilkinson, J M, van Meurs, J B J, Zeggini, E, Cootes, T, Lindner, C, Kemp, J P, Davey Smith, G & Tobias, J H 2023, ' A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults ', Arthritis and Rheumatology, vol. 75, no. 6, pp. 900-909 . https://doi.org/10.1002/art.42451
Arthritis and Rheumatology, 75(6), 900-909. John Wiley & Sons Ltd.

Objective: To examine the genetic architecture of cam morphology using alpha angle (AA) as a proxy measure and conduct an AA genome-wide association study (GWAS) followed by Mendelian randomization (MR) to evaluate its causal relationship with hip os

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd8b0936adf27c13378ae0983ce92e5
https://doi.org/10.1002/art.42451

Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank

Autor: Fiona R. Saunders, Richard M. Aspden, Timothy F. Cootes, G Davey Smith, Claudia Lindner, B.G. Faber, Raja Ebsim, Monika Frysz, Nicholas C. Harvey, Jennifer S. Gregory, Jonathan H Tobias

Publikováno v: Faber, B G, Ebsim, R, Saunders, F R, Frysz, M, Gregory, J S, Aspden, R M, Harvey, N, Smith, G D, Cootes, T, Lindner, C & Tobias, J H 2021, ' Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank ', Osteoarthritis and Cartilage, vol. 29, no. 11, pp. 1521-1529 . https://doi.org/10.1016/j.joca.2021.08.002
Faber, B G, Frysz, M R, Davey Smith, G, Tobias, J H & al., E 2021, ' Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip : findings from a cross-sectional study in UK Biobank ', Osteoarthritis and Cartilage, vol. 29, no. 11, pp. 1521-1529 . https://doi.org/10.1016/j.joca.2021.08.002
Osteoarthritis and Cartilage

Objectives To examine whether acetabular dysplasia (AD), cam and/or pincer morphology are associated with radiographic hip osteoarthritis (rHOA) and hip pain in UK Biobank (UKB) and, if so, what distribution of osteophytes is observed.DesignParticipa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfa5ab992a47c9bde72228c251ff680
https://doi.org/10.1016/j.joca.2021.08.002

Motor development in infancy and spine shape in early old age: Findings from a British birth cohort study

Autor: Rebecca Hardy, Alex Ireland, Richard M. Aspden, Rachel Cooper, Pavlova Av, Jennifer S. Gregory, Stella G. Muthuri, Diana Kuh, Judith E. Adams, Fiona R. Saunders, Kathryn R. Martin, Rebecca J. Barr

Publikováno v: Journal of Orthopaedic Research

Spine shape changes dramatically in early life, influenced by attainment of developmental milestones such as independent walking. Whether these associations persist across life is unknown. Therefore, we investigated associations between developmental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef0148754a261c1350a3da44b796f0a
https://doi.org/10.1002/jor.24656

Osteoarthritis as an organ disease: from the cradle to the grave

Autor: Richard M. Aspden, Fiona R. Saunders

Publikováno v: European Cells & Materials, Vol 37, Pp 74-87 (2019)

Considered for decades as a cartilage disease, recent studies of osteoarthritis (OA) take us back to the concepts discussed at the naming of the disorder as "bone-joint-inflammation". By describing the joint as an organ, can OA be called an organ dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a0a639415ec75d0fbe4b6676b213a2
https://doi.org/10.22203/ecm.v037a06