Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Fiona O'Mahony"'
Autor:
Kara Clerkin, Simon W. Beaven, Jihane N. Benhammou, Sheila M. O'Byrne, Kevin Wroblewski, Fiona O’Mahony, William S. Blaner, Hongfeng Jiang
Publikováno v:
Hepatology. 62:615-626
Liver X receptors (LXRs) are determinants of hepatic stellate cell (HSC) activation and liver fibrosis. Freshly isolated HSCs from Lxrαβ−/− mice have increased lipid droplet (LD) size, but the functional consequences of this are unknown. Our ai
Publikováno v:
Molecular Endocrinology. 26:2058-2070
Most cancers use glucose as substrate for aerobic glycolysis in preference to oxidative phosphorylation. However, variable glucose concentrations within the in-vivo tumor microenvironment may necessitate metabolic plasticity. Furthermore, little info
Autor:
Fiona O'Mahony, Rodrigo Alzamora, Francisco V. Sepúlveda, Raphael Rapetti-Mauss, Brian J. Harvey, Valerie Urbach, Viviana Bustos, L. Pablo Cid
Publikováno v:
The Journal of Physiology. 589:5091-5107
The KCNQ1 potassium channel associates with various KCNE ancillary subunits that drastically affect channel gating and pharmacology. Co-assembly with KCNE3 produces a current with nearly instantaneous activation, some time-dependent activation at ver
Publikováno v:
Molecular Endocrinology. 24:2152-2165
Development of cardiac fibrosis portends the transition and deterioration from hypertrophy to dilation and heart failure. Here we examined how estrogen blocks this important development. Angiotensin II (AngII) and endothelin-1 induce cardiac hypertro
Publikováno v:
Molecular Endocrinology. 23:1885-1899
The secretion of Cl− across distal colonic crypt cells provides the driving force for the movement of fluid into the luminal space. 17β-Estradiol (E2) produces a rapid and sustained reduction in secretion in females, which is dependent on the nove
Publikováno v:
The Journal of Physiology. 587:5039-5044
The intestine is an oestrogen responsive organ and circulatory oestrogens suppress Cl(-) secretion across the epithelium of the colon to promote fluid retention at the luteal stage of the menstrual cycle. Ion transporters in the colon which are invol
Autor:
Mustapha Irnaten, Brian J. Harvey, Rodrigo Alzamora, Fiona O'Mahony, Franck LaPaix, Vicki Betts, Derek Carter
Publikováno v:
Journal of Biological Chemistry. 282:24563-24573
The estrogen sex steroid 17beta-estradiol rapidly inhibits secretagogue-stimulated cAMP-dependent Cl(-) secretion in the female rat distal colonic crypt by the inhibition of basolateral K(+) channels. In Ussing chamber studies, both the anti-secretor
Autor:
Robert S. Brown, Manel Esteller, Peter A. Dervan, Alison A. Murphy, Edward J. Fox, William M. Gallagher, Ilse-Maria Nolan, Orla Bergin, Fiona O'Mahony, David J. Easty, Linda Hughes, Raymond L. Stallings, Aedín C. Culhane, Mario F. Fraga, Susan McDonnell, Jane A. Plumb, L. McArdle, Mairin Rafferty, Aileen Byrne, Caroline A. Currid, Zoe D. Kelly, Catherine Moss
Publikováno v:
Carcinogenesis. 26:1856-1867
The incidence of melanoma is increasing rapidly, with advanced lesions generally failing to respond to conventional chemotherapy. Here, we utilized DNA microarray-based gene expression profiling techniques to identify molecular determinants of melano
Autor:
Michael E. Jung, Peter M. Clark, Evan Nair-Gill, Fiona O’Mahony, Nikolai M. Evdokimov, Graciela Flores, Michael E. Phelps, Kym F. Faull, Owen N. Witte, Timothy Chai, Simon W. Beaven, Melissa N. McCracken
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 28
Clark, PM; Flores, G; Evdokimov, NM; McCracken, MN; Chai, T; Nair-Gill, E; et al.(2014). Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proceedings of the National Academy of Sciences of the United States of America, 111(28), E2866-E2874. doi: 10.1073/pnas.1410326111. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1762d77s
Clark, PM; Flores, G; Evdokimov, NM; McCracken, MN; Chai, T; Nair-Gill, E; et al.(2014). Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proceedings of the National Academy of Sciences of the United States of America, 111(28), E2866-E2874. doi: 10.1073/pnas.1410326111. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1762d77s
PET is a powerful technique for quantifying and visualizing biochemical pathways in vivo. Here, we develop and validate a novel PET probe, [(18)F]-2-deoxy-2-fluoroarabinose ([(18)F]DFA), for in vivo imaging of ribose salvage. DFA mimics ribose in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1584be995ffcdb7e5779dc1511e57f
https://escholarship.org/uc/item/1762d77s
https://escholarship.org/uc/item/1762d77s
Publikováno v:
Science signaling. 6(276)
Estrogen induces signal transduction through estrogen receptor α (ERα), which localizes to both the plasma membrane and nucleus. Using wild-type mice, ERα knockout (ERKO) mice, or transgenic mice expressing only the ligand-binding domain of ERα e