Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial

Autor: Holly R Keir, Merete B Long, Hani Abo-Leyah, Yan Hui Giam, Thenmalar Vadiveloo, Thomas Pembridge, Rebecca C Hull, Lilia Delgado, Margaret Band, Fiona McLaren-Neil, Simon Adamson, Eva Lahnsteiner, Amy Gilmour, Chloe Hughes, Benjamin JM New, David Connell, Rebecca Dowey, Helena Turton, Hollian Richardson, Diane Cassidy, Jamie Cooper, Jay Suntharalingam, Lavanya Diwakar, Peter Russell, Jonathan Underwood, Alexander Hicks, Davinder PS Dosanjh, Beth Sage, Devesh Dhasmana, Mark Spears, AA Roger Thompson, Christopher Brightling, Andrew Smith, Manish Patel, Jacob George, Alison M Condliffe, Amelia Shoemark, Graeme MacLennan, James D Chalmers, James Chalmers, Christine Almaden-Boyle, Jennifer Taylor, Jodie Strachan, Heather Loftus, Lesley Young, Angela Strachan, Kristina Pilvinyte, Petra Rauchhaus, Fiona Hogarth, Tricia Burns, Elizabeth Coote, Marney Keiller, Elizabeth Sage, David Miller, Davinder Dosanjh, Benjamin Sutton, Sharon Frayling, Matthew Haynes, Lauren Broad, Laura Jones, Karen Rahilly, Catherine Oliver, Terriann Evans, Andrea Balan, Rhys Davies, Donal Forde, Clemency Nye, Dr Haboubi, Zoe Hilton, Jennie Williams, Alison McQueen, Ian Edmond, Dario Salutous, Laura McGenily, Rhona Scott, Eilidh Henderson, Andrea Collins, Patrick Liu, Ana Morrow, Mandy Couser, Fleur Davey, Laura Wiffen, Lauren Fox, Mohamed Abdelrahim, Alexander Darbyshire, Elena Cowen, Megan Rowley, Benjamin Giles, Yingjia Yang, Tom Brown, Hitasha Rupani, Elizabeth Hawes, Debi Barnes, Fiona Brogan, Roneleeh Bungue-Tuble, Serena Howe, Charlotte Turner, Sonia Baryschpolec, Bev Longhurst, Maria Moon, Lynn Watkins, Michelle Baker-Moffat, Lisa Murray, Yasmin Harrington-Davies, Kate Burrows, Chrissie Minnis, Mary Wands, Adefunke Bamgboye, Charlotte Wong, Sarah Diver, Richard Russell, Hamish McAuley, Omer Elneima, Ahmed Yousuf, Paula McCourt, Beverley Hargadon, Sarah Parker, Michelle Bourne, Tom Hartley, Vidan Masan, Sharon Sturney, Rob MacKenzie, Clare Marchand, Rebecca Mason, Katie White, Alison Kirby, Manjula Meda, Joanne Finn, Sophie Harris, Carol Muir, Gemma Cook, Nikki Staines, Chris Cook, Alison Condliffe, Rebecca Hull, Paul Collini, Zoé Gabriel, Simon Hardman, Helen Newell, Janet Middle, Phillip Simpson, Hayley Colton, Joann Barker, Katie Birchall, Kate Harrington, Kay Housley, Rebecca Lenagh, Jayne Wilson, Joan Wesonga, Rachel Whitham, Sarah Bird, Yvonne Jackson, Angeline Mbuyisa, Samantha Anderson, Anna Wilson, Faith Kibutu, Sara Walker, Kay Cawthron, Irene Macharia, Lynne Smart, Anna Emery, Alice Howell, Elizabeth Hurditch, Amber Ford, Kim Turner, Lisa Watson, Helen Bowler, Tracy Jackson, Carol Jaques, Nichole Dyer, Shelley Ducker, Vicky Goodall, Emily Udale

This study was funded by an investigator-initiated research grant from Insmed (Bridgewater, NJ, USA). The authors acknowledge the funding and logistical support from the UK National Institute for Health and Care Research. Background: Neutrophil serin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f832a45ad7d7f0d50d9a326a100f7d7b
https://eprints.whiterose.ac.uk/190854/1/1-s2.0-S2213260022002612-main.pdf

Improving the Quality of Dentistry (IQuaD): a cluster factorial randomised controlled trial comparing the effectiveness and cost–benefit of oral hygiene advice and/or periodontal instrumentation with routine care for the prevention and management of periodontal disease in dentate adults attending dental primary care

Autor: Debbie Bonetti, Rebecca Bruce, PA Heasman, Jan E Clarkson, Fiona McLaren-Neil, Linda Young, Graeme Watt, Thomas Lamont, Fiona E. Mitchell, Alex Sharp, Beatriz Goulao, Kirsty Sim, Jimmy Steele, John Norrie, Giles McCracken, Craig R Ramsay, Marjon van der Pol, Laura A. Lovelock-Hempleman, Alison McDonald, Dwayne Boyers, Jill Gouick, Helen V Worthington, L Heasman, Anne Duncan, Lorna E. Macpherson

Publikováno v: Ramsay, C R, Clarkson, J E, Duncan, A, Lamont, T J, Heasman, P A, Boyers, D, Goulão, B, Bonetti, D, Bruce, R, Gouick, J, Heasman, L, Lovelock-hempleman, L A, Macpherson, L E, Mccracken, G I, Mcdonald, A M, Mclaren-neil, F, Mitchell, F E, Norrie, J D, Van Der Pol, M, Sim, K, Steele, J G, Sharp, A, Watt, G, Worthington, H V & Young, L 2018, ' Improving the Quality of Dentistry (IQuaD): a cluster factorial randomised controlled trial comparing the effectiveness and cost–benefit of oral hygiene advice and/or periodontal instrumentation with routine care for the prevention and management of periodontal disease in dentate adults attending dental primary care ', Health Technology Assessment, vol. 22, no. 38, pp. 1-144 . https://doi.org/10.3310/hta22380
Health Technology Assessment, Vol 22, Iss 38 (2018)

Background Periodontal disease is preventable but remains the most common oral disease worldwide, with major health and economic implications. Stakeholders lack reliable evidence of the relative clinical effectiveness and cost-effectiveness of differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353f01504fb7cebefb16dcef99f90426
https://doi.org/10.3310/hta22380

[Untitled]

Autor: Fiona McLaren, Robert W. Hay

Publikováno v: Transition Metal Chemistry. 24:398-402

The N-bonded nitrile complexes αα-[Co(tetren)NCR]3+ (R=Me, Ph, p-MeOC6 H4) have been prepared by the reaction of αα-[Co(tetren)OH2]3+ with the corresponding nitrile. The kinetics of base hydrolysis have been studied by pH-stat methods. The reacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b07b4b348c64bb7c723e4054f8e5abe
https://doi.org/10.1023/a:1006913306411

Small cell lung cancer tumour cells induce regulatory T lymphocytes, and patient survival correlates negatively with FOXP3+ cells in tumour infiltrate

Autor: Wei Wang, Philip S. Hodkinson, Sarah E. M. Howie, William Wallace, Fiona McLaren, Tariq Sethi, Alison C. MacKinnon

Publikováno v: International journal of cancer. 131(6)

Small cell lung cancer (SCLC) kills at least one person every 2 hr in the United Kingdom. Some patients do relatively well but most have rapidly progressive disease. There is no effective treatment and overall 2-year survival is less than 5%. Patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5827f36ed5116d84b9aeaa33a6f686
https://pubmed.ncbi.nlm.nih.gov/22532287

Synthetic and kinetic studies on copper(II), nickel(II) and cobalt(III) complexes of 1,4,7,11,14-penta-azacycloheptadecane([17]aneN5)

Autor: Robert W. Hay, W. Thomas Moodie, Fiona McLaren, Ramesh Bembi

Publikováno v: Inorganica Chimica Acta. 85:23-31

The preparation of the pentadentate macrocyclic ligand L (= II, 4,7,11,14-penta-azacycloheptadecane) is described. The complexes [CuL](ClO4)2, [NiL(H2O)](ClO4)2, [CoClL](ClO4)2, [CoL(CO3)]ClO4, [Co([15]aneN5)CO3]ClO4, [CoL(DMF)](ClO4)3, [CoL(OOCH)](C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cdc2d84b9d622aab665c76a5e47a088
https://doi.org/10.1016/s0020-1693(00)81021-x