Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Fiona M. Jucker"'
Publikováno v:
Biochemistry. 46:3826-3834
The hammerhead ribozyme from Schistosoma mansoni is the best characterized of the natural hammerhead ribozymes. Biophysical, biochemical, and structural studies have shown that the formation of the loop-loop tertiary interaction between stems I and I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a829dbd417c86613b0dd16773f7936
https://doi.org/10.1021/bi062077r
https://doi.org/10.1021/bi062077r
Autor:
David T. Shima, Yin-Shan Ng, Fiona M. Jucker, Arthur Pardi, Dominik Krilleke, Marella D. Canny, Joon-Hwa Lee, Andrea De Erkenez
Publikováno v:
Proceedings of the National Academy of Sciences. 102:18902-18907
Aptamers recognize their targets with extraordinary affinity and specificity. The aptamer-based therapeutic, Macugen, is derived from a modified 2′fluoro pyrimidine RNA inhibitor to vascular endothelial growth factor (VEGF) and is now being used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f4016b2668638bf564a4e9bab976e1
https://doi.org/10.1073/pnas.0509069102
https://doi.org/10.1073/pnas.0509069102
Publikováno v:
Biochemistry. 42:2560-2567
The helical regions of RNA are generally very stable, but the single-stranded and loop regions often exist as an ensemble of conformations in solution. The theophylline-binding RNA aptamer forms a very stable structure when bound to the bronchodilato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::585c707e1f71c2d8a12158a2118f950d
https://doi.org/10.1021/bi027103+
https://doi.org/10.1021/bi027103+
Publikováno v:
Biopolymers. 52:168-180
NMR solution structures of nucleic acids are generally less well defined than similar-sized proteins. Most NMR structures of nucleic acids are defined only by short-range interactions, such as intrabase-pair or sequential nuclear Overhauser effects (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ccd5a472ab76011102f24dafdc83b0
https://doi.org/10.1002/1097-0282(1999)52:4<168::aid-bip1002>3.0.co
https://doi.org/10.1002/1097-0282(1999)52:4<168::aid-bip1002>3.0.co
Publikováno v:
Journal of Biomolecular NMR. 10:245-253
The power of heteronuclear NMR spectroscopy to study macromoleculesand their complexes has been amply demonstrated over the last decade. Theobstacle to routinely applying these techniques to the study of DNA has beenthe synthesis of 13C,15N-labeled D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74e2f94c614c24428b2667b9a11bd1b2
https://doi.org/10.1023/a:1018358602001
https://doi.org/10.1023/a:1018358602001
Publikováno v:
Journal of Molecular Biology. 264:968-980
RNA hairpin loops containing a GNRA consensus sequence are the most frequently occurring hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play important functional roles in RNA folding, in RNA – RNA tertiary interactions a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d0cf991aec8331814a2d9b460138c7
https://doi.org/10.1006/jmbi.1996.0690
https://doi.org/10.1006/jmbi.1996.0690
Publikováno v:
FEBS Letters. 362:156-160
3JCP coupling constants have been measured in 1 99% 13C, 15N labeled lead-dependent ribozyme, known as the leadzyme. These coupling constants were determined by analysis of the intensity of individual crosspeaks in a spin-echo difference constant tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf51e19ab4f10b97cb7047d101faaf2
https://doi.org/10.1016/0014-5793(95)00232-x
https://doi.org/10.1016/0014-5793(95)00232-x
Publikováno v:
Biochemistry. 42(9)
The helical regions of RNA are generally very stable, but the single-stranded and loop regions often exist as an ensemble of conformations in solution. The theophylline-binding RNA aptamer forms a very stable structure when bound to the bronchodilato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d7b7a7377a218b7b6efef38ea6a37f8
https://pubmed.ncbi.nlm.nih.gov/12614150
https://pubmed.ncbi.nlm.nih.gov/12614150
Autor:
Theodore M. Tarasow, Bruce E. Eaton, Michael Willis, Fiona M. Jucker, Brian Hicke, Larry Gold, David P. Sebesta, Nebojša Janjié, Dominic Zichi
Publikováno v:
Bioorganicmedicinal chemistry. 5(6)
In vitro selection techniques provide a means of isolating nucleic acid ligands for binding to particular protein targets. Although most aptamers have quite high affinities for their target proteins, it has been shown that post-SELEX modification can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2081ad0551d90f6bff795496d77581ba
https://pubmed.ncbi.nlm.nih.gov/9222502
https://pubmed.ncbi.nlm.nih.gov/9222502
Autor:
Bruce D. Feistner, Derek Jellinek, Stanley C. Gill, Louis S. Green, Laurie A. Beebe, Fiona M. Jucker, Carol Bell, Nebojsa Janjic
Publikováno v:
Chemistry & Biology. 3(11)
Background : Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) is a potent inducer of new blood vessel growth (angiogenesis) that contributes to the pathology of many angiogenesis-associated disease states such as psoriasis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086ce2f6e131e9eb33f731f2b777c1a5