Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Fiona M. Behan"'
Autor:
Emanuel Gonçalves, Mark Thomas, Fiona M. Behan, Gabriele Picco, Clare Pacini, Felicity Allen, Alessandro Vinceti, Mamta Sharma, David A. Jackson, Stacey Price, Charlotte M. Beaver, Oliver Dovey, David Parry-Smith, Francesco Iorio, Leopold Parts, Kosuke Yusa, Mathew J. Garnett
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many applications. We design an optimised minimal genome-wide human CRISPR-Cas9 library (MinLibC
Externí odkaz:
https://doaj.org/article/2fa4d024f7b14d10b1fef8e9f3b2d270
Autor:
Joshua M. Dempster, Clare Pacini, Sasha Pantel, Fiona M. Behan, Thomas Green, John Krill-Burger, Charlotte M. Beaver, Scott T. Younger, Victor Zhivich, Hanna Najgebauer, Felicity Allen, Emanuel Gonçalves, Rebecca Shepherd, John G. Doench, Kosuke Yusa, Francisca Vazquez, Leopold Parts, Jesse S. Boehm, Todd R. Golub, William C. Hahn, David E. Root, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Integrating independent large-scale pharmacogenomic screens can enable unprecedented characterization of genetic vulnerabilities in cancers. Here, the authors show that the two largest independent CRISPR-Cas9 gene-dependency screens are concordant, p
Externí odkaz:
https://doaj.org/article/7101cce4933e4a7a88c0656de01f28e5
Autor:
Gabriele Picco, Elisabeth D. Chen, Luz Garcia Alonso, Fiona M. Behan, Emanuel Gonçalves, Graham Bignell, Angela Matchan, Beiyuan Fu, Ruby Banerjee, Elizabeth Anderson, Adam Butler, Cyril H. Benes, Ultan McDermott, David Dow, Francesco Iorio, Euan Stronach, Fengtang Yang, Kosuke Yusa, Julio Saez-Rodriguez, Mathew J. Garnett
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Gene fusions are observed in many cancers but their link to tumour fitness is largely unknown. Here, transcriptomic analysis combined with pharmacological and CRISPR-Cas9 screening of cancer cell lines was used to evaluate the functional linkage betw
Externí odkaz:
https://doaj.org/article/faee146ac94c4c129948d57be9f339e0
Autor:
Emanuel Gonçalves, Fiona M. Behan, Sandra Louzada, Damien Arnol, Euan A. Stronach, Fengtang Yang, Kosuke Yusa, Oliver Stegle, Francesco Iorio, Mathew J. Garnett
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background CRISPR-Cas9 genome editing is widely used to study gene function, from basic biology to biomedical research. Structural rearrangements are a ubiquitous feature of cancer cells and their impact on the functional consequences of CRI
Externí odkaz:
https://doaj.org/article/3516f76650ac43208fd3373ec80b00ab
Autor:
Francesco Iorio, Fiona M. Behan, Emanuel Gonçalves, Shriram G. Bhosle, Elisabeth Chen, Rebecca Shepherd, Charlotte Beaver, Rizwan Ansari, Rachel Pooley, Piers Wilkinson, Sarah Harper, Adam P. Butler, Euan A. Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background Genome editing by CRISPR-Cas9 technology allows large-scale screening of gene essentiality in cancer. A confounding factor when interpreting CRISPR-Cas9 screens is the high false-positive rate in detecting essential genes within c
Externí odkaz:
https://doaj.org/article/1bb1e9839ee048d0acfbc344b2b5b02a
Autor:
Shane P. Duggan, Catherine Garry, Fiona M. Behan, Sinead Phipps, Hiromi Kudo, Murat Kirca, Abdul Zaheer, Sarah McGarrigle, John V. Reynolds, Robert Goldin, Steve E. Kalloger, David F. Schaeffer, Aideen Long, Jessica Strid, Dermot Kelleher
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 569-590 (2018)
Background & Aims: Effective therapeutic approaches are urgently required to tackle the alarmingly poor survival outcomes in esophageal adenocarcinoma (EAC) patients. EAC originates from within the intestinal-type metaplasia, Barrett’s esophagus, a
Externí odkaz:
https://doaj.org/article/e381e10aa93b40ad9133592402527bdf
Publikováno v:
Genome Editing in Drug Discovery. :47-59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc40c34bdceac870138810c1c14209dd
https://doi.org/10.1002/9781119671404.ch4
https://doi.org/10.1002/9781119671404.ch4
Autor:
Raffaele Iannuzzi, Ichcha Manipur, Clare Pacini, Fiona M. Behan, Mario R. Guarracino, Mathew J. Garnett, Aurora Savino, Francesco Iorio
Genome-wide recessive genetic screens using lentiviral CRISPR-guide RNA libraries are widely performed in mammalian cells to functionally characterise individual genes and for the discovery of new anti-cancer therapeutic targets. As the effectiveness
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67f8955d373925acd92bbc38323d152d
https://doi.org/10.1101/2022.09.23.509258
https://doi.org/10.1101/2022.09.23.509258
Autor:
Lisa Dwane, Francesco Iorio, Howard Lightfoot, Wanjuan Yang, Mathew J. Garnett, Miguel Pignatelli, Emanuel Gonçalves, Rebecca Shepherd, Dieudonne van der Meer, Fiona M. Behan
Publikováno v:
Nucleic Acids Research
CRISPR genetic screens in cancer cell models are a powerful tool to elucidate oncogenic mechanisms and to identify promising therapeutic targets. The Project Score database (https://score.depmap.sanger.ac.uk/) uses genome-wide CRISPR–Cas9 dropout s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155d18294b44edb15808d22990f0f2ee
https://doi.org/10.1093/nar/gkaa882
https://doi.org/10.1093/nar/gkaa882
Autor:
Julio Saez-Rodriguez, Graham R. Bignell, Euan A. Stronach, Beiyuan Fu, Angela Matchan, Fiona M. Behan, Emanuel Gonçalves, Ruby Banerjee, Elisabeth Chen, Ultan McDermott, Gabriele Picco, Fengtang Yang, Kosuke Yusa, Luz Garcia Alonso, Cyril H. Benes, David J. Dow, Adam Butler, Elizabeth Anderson, Francesco Iorio, Mathew J. Garnett
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Many gene fusions are reported in tumours and for most their role remains unknown. As fusions are used for diagnostic and prognostic purposes, and are targets for treatment, it is crucial to assess their function in cancer. To systematically investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e59227420fb1fc4592cbf1bb8cb97b3
https://doaj.org/article/faee146ac94c4c129948d57be9f339e0
https://doaj.org/article/faee146ac94c4c129948d57be9f339e0