Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Fiona M. Adam"'
Autor:
Kathy F. K. Cheung, Jean-Yves Chiva, Satish Dayal, Darren Stead, Carly L. Nichols, Rob Webster, Lee R. Roberts, David Stonehouse, Felice Daverio, Iain Gardner, Andrew Pike, Michael Paradowski, David C. Blakemore, Gilles H. Goetz, Lesa Watson, Chris Pickford, Jared B.J. Milbank, Ye Che, Robert Wybrow, Florian Wakenhut, Keith Statham, Caroline Smith-Burchnell, Samuel Crook, Fiona M. Adam, David C. Pryde, David Leese, Mike Westby, Duncan Hay, Stephen M. Shaw, Tram T. Tran
Publikováno v:
ChemMedChem. 9:1378-1386
Nonstructural protein 5A (NS5A) represents a novel target for the treatment of hepatitis C virus (HCV). Daclatasvir, recently reported by Bristol-Myers-Squibb, is a potent NS5A inhibitor currently under investigation in phase 3 clinical trials. While
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f34d031ac0ffb04451e59d88ca8e2e5
https://doi.org/10.1002/cmdc.201400045
https://doi.org/10.1002/cmdc.201400045
Autor:
Tram T. Tran, Rachel Dixon, Duncan Hay, James Hitchin, Gemma C. Parsons, David C. Pryde, Gerwyn Bish, Michael Paradowski, Fiona M. Adam, Nicholas Smith, Peter Jones, M. Jonathan Fray, Katie J. W. Proctor, Frederick Calo
Publikováno v:
Tetrahedron Letters. 52:5728-5732
A flexible route which enables access to derivatives of 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-ones is described. Issues of selectivity, reaction safety, and low yields in original routes are overcome with the key improvements to the route, inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c13cab43378c9676f70600e4494b897b
https://doi.org/10.1016/j.tetlet.2011.08.119
https://doi.org/10.1016/j.tetlet.2011.08.119
Autor:
Craig J. Knight, Katie J. W. Proctor, Nicholas Smith, David C. Pryde, Christopher L. Carr, Peter Jones, Gerwyn Bish, Nieves Castro, Hodgson Paul Blaise, Filippo Rota, Frederick Calo, Duncan Hay, Mya C. Smith, James Hitchin, Tram T. Tran, Rachel Dixon, Michael Paradowski, Fiona M. Adam, Gemma C. Parsons
Publikováno v:
Organic Process Research & Development. 15:788-796
The development and implementation of a scalable process for the manufacture of the Toll-like receptor (TLR7) agonist PF-4171455 (1) is described. Initial routes used to synthesise 1 in milligram quantities were unsuitable for large-scale synthesis t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25b51da65de0e0a90344001848dd6c54
https://doi.org/10.1021/op200021a
https://doi.org/10.1021/op200021a
Autor:
Carl Laxton, Nicholas Smith, Martin Howard, Gerwyn Bish, Duncan Hay, Mya C. Smith, James Hitchin, Tram T. Tran, David C. Pryde, Hannah M. Jones, Peter Jones, Nigel Horscroft, Gemma C. Parsons, Rachel Dixon, Frederick Calo, Katie J. W. Proctor, Fox David Nathan Abraham, Jonathan Duckworth, Neil Benson, Amy Thomas, Iain Gardner, Tanya Parkinson, Fiona M. Adam, Guiseppe Ciaramella
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2389-2393
The synthesis and structure-activity relationships of a series of novel interferon inducers are described. Pharmacokinetic studies and efficacy assessment of a series of 8-oxo-3-deazapurine analogues led to the identification of compound 33, a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3f64c50e8a92b29c2e40cbf07d158d
https://doi.org/10.1016/j.bmcl.2011.02.092
https://doi.org/10.1016/j.bmcl.2011.02.092
Autor:
Gerwyn Bish, Anthony Harrison, Michael Paradowski, Nicholas Smith, Gemma C. Parsons, Tanya Parkinson, Donald Stuart Middleton, Carl Laxton, Peter Jones, Fox David Nathan Abraham, Tram T. Tran, Fiona M. Adam, Hannah M. Jones, Giuseppe Ciaramella, Frederick Calo, Jonathan Duckworth, Katie J. W. Proctor, David C. Pryde, Rob Webster, Duncan Hay, Mya C. Smith, Neil Benson, Nigel Horscroft
Publikováno v:
Med. Chem. Commun.. 2:185-189
A series of heterocycle analogues of an adenine template were explored for TLR7 agonist potency and pharmacokinetics. One compound was identified with an excellent pharmacokinetic, in vitro potency and in vivo interferon induction profile in a mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20345103a70c1c2f6f7d0a88c9962d6f
https://doi.org/10.1039/c0md00197j
https://doi.org/10.1039/c0md00197j
Autor:
Rawal Jaiessh, Amy Randall, Tram T. Tran, Fiona M. Adam, Daniel Siddle, Iain Gardner, Tanya Parkinson, Manos Perros, David R. Fenwick, Christopher Pickford, Juin Fok-Seang, Charles E. Mowbray, David Howard Williams, Donald Stuart Middleton, Hannah Vuong, Peter T. Stephenson, Michelle Y. Platts, Duncan Hay
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5246-5249
A series of piperazine derivatives were designed and synthesised as gp120-CD4 inhibitors. SAR studies led to the discovery of potent inhibitors in a cell based anti viral assay represented by compounds 9 and 28. The rat pharmacokinetic and antiviral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3a4d25958155d25e9e2f74217f4f79
https://doi.org/10.1016/j.bmcl.2009.06.080
https://doi.org/10.1016/j.bmcl.2009.06.080
Autor:
Andrew J. Burton, Mark B. Schilling, Keith Mills, Richard A. Henson, Fiona M. Adam, Daniel Terence Tape, Richard Cox, Jeremy C. Prodger, Kevin S. Cardwell
Publikováno v:
Tetrahedron Letters. 44:5657-5659
New syntheses of the amino-1,2,4-triazine, GW356194 have been developed to improve on existing methodology. The use of different amidrazones in cyclisations with α-keto and α-amido carbonyl compounds as the key step for the synthesis of the 1,2,4-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79aeda7f28b4e559629fd298e2973eeb
https://doi.org/10.1016/s0040-4039(03)01359-5
https://doi.org/10.1016/s0040-4039(03)01359-5
Autor:
Carl Laxton, David C. Pryde, Fiona M. Adam, Gerwyn Bish, Duncan Hay, Mya C. Smith, James Hitchin, Peter Jones, Tanya Parkinson, Nigel Horscroft, Tram T. Tran, Jonathan Duckworth, Rachel Dixon, Gemma C. Parsons, Guiseppe Ciaramella, Fox David Nathan Abraham, Katie J. W. Proctor, Frederick Calo, Amy Thomas, Nicholas Smith, Martin Howard
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(19)
The discovery of a series of highly potent and novel TLR7 agonist interferon inducers is described. Structure-activity relationships are presented, along with pharmacokinetic studies of a lead molecule from this series of N9-pyridylmethyl-8-oxo-3-dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934d1fcd9e52845e8234105509bed653
https://pubmed.ncbi.nlm.nih.gov/21885277
https://pubmed.ncbi.nlm.nih.gov/21885277
Autor:
Jaiessh Rawal, David Howard Williams, Donald Stuart Middleton, Michelle Y. Platts, Juin Fok-Seang, Manos Perros, Frederick Calo, Duncan Hay, Christopher Pickford, David R. Fenwick, Tram T. Tran, Hannah Vuong, Fiona M. Adam, Iain Gardner, Tanya Parkinson, Peter T. Stephenson, Amy Randall
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(17)
The synthesis and structure-activity relationship of a series of novel gp120-CD4 inhibitors are described. Pharmacokinetic studies and antiviral spectrum assessment of lead compounds led to the identification of compound 36, a potent gp120-CD4 inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0315d777c77dc2ffe5cf5ff5806e52ce
https://pubmed.ncbi.nlm.nih.gov/19632839
https://pubmed.ncbi.nlm.nih.gov/19632839