Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Fiona M Platt"'
Autor:
Carolyn D Hurst, Guo Cheng, Fiona M Platt, Olivia Alder, Emma VI Black, Julie E Burns, Joanne Brown, Sunjay Jain, Jo‐An Roulson, Margaret A Knowles
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 3, Pp 279-293 (2022)
Abstract Pure squamous cell carcinoma (SCC) is the most common pure variant form of bladder cancer, found in 2–5% of cases. It often presents late and is unresponsive to cisplatin‐based chemotherapy. The molecular features of these tumours have n
Externí odkaz:
https://doaj.org/article/37062d89cb4f4c22859e462534494f59
Autor:
Geoffrey A Pettitt, Carolyn D Hurst, Zubeda Khan, Helen R McPherson, Matthew C Dunning, Olivia Alder, Fiona M Platt, Emma VI Black, Julie E Burns, Margaret A Knowles
Publikováno v:
The Journal of Pathology. 259:220-232
Alterations of fibroblast growth factor receptors (FGFRs) are common in bladder and other cancers and result in disrupted signalling via several pathways. Therapeutics that target FGFRs have now entered the clinic, but in common with many cancer ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3c8413f678b31e2f287b30e95dbab9
https://doi.org/10.1002/path.6034
https://doi.org/10.1002/path.6034
PDF file, 123K, Copy number (CN), mutation status (MS), loss of heterozygosity analysis (LOH) and immunohistochemistry (IHC) data for all tumors (n=160).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28749a91f9bd76f21abed9ddeb3f336
https://doi.org/10.1158/1078-0432.22446230
https://doi.org/10.1158/1078-0432.22446230
Autor:
Margaret A. Knowles, Patricia Harnden, Walter M. Gregory, Claire F. Taylor, Carolyn D. Hurst, Fiona M. Platt
Purpose: The phosphatidylinositol 3-kinase (PI3K) pathway can be activated by alterations affecting several pathway components. For rational application of targeted therapies, detailed understanding of tumor biology and approaches to predict efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdd285e1d11f19d68b2766d8908f4f6
https://doi.org/10.1158/1078-0432.c.6517393
https://doi.org/10.1158/1078-0432.c.6517393
PDF file, 59K, Relationship between copy number gains and losses and individual Ta, T1G3 and ≥T2 clusters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26caaea55d5f6eab85f849ceb766bc94
https://doi.org/10.1158/1078-0432.22446206
https://doi.org/10.1158/1078-0432.22446206
Purpose: There is a need for improved subclassification of urothelial carcinoma (UC) at diagnosis. A major aim of this study was to search for novel genomic subgroups.Experimental design: We assessed 160 tumors for genome-wide copy number alterations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e462cfc91bc1a9cec583b63003d5421
https://doi.org/10.1158/1078-0432.c.6520682.v1
https://doi.org/10.1158/1078-0432.c.6520682.v1
PDF file, 507K, Relationship between PTEN loss, RB1 loss and TP53 mutation status and time to metastasis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfb26a796d3b4afe8c49ed183910460
https://doi.org/10.1158/1078-0432.22446233.v1
https://doi.org/10.1158/1078-0432.22446233.v1
PDF file, 3635K, Unsupervised hierarchical cluster analysis of aCGH data from all tumor samples and genome-wide frequency plots of copy number alterations in individual ≥T2 clusters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f990eb3b062e6a9da1882a272964d96
https://doi.org/10.1158/1078-0432.22446227
https://doi.org/10.1158/1078-0432.22446227
PDF file, 902K, Loss and gain in tumors from individual Ta, T1 and ≥T2 clusters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8d71b0490594e1f5d36a9bde0c4343
https://doi.org/10.1158/1078-0432.22446224.v1
https://doi.org/10.1158/1078-0432.22446224.v1