Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Fiona M Keane"'
Autor:
Shirley Uitte de Willige, Fiona M Keane, David G Bowen, Joyce J M C Malfliet, H Emma Zhang, Bharvi Maneck, Geoffrey W McCaughan, Frank W G Leebeek, Dingeman C Rijken, Mark D Gorrell
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178987 (2017)
BACKGROUND AND AIM:Circulating fibroblast activation protein (cFAP) is a constitutively active enzyme expressed by activated fibroblasts that has both dipeptidyl peptidase and endopeptidase activities. We aimed to assess the correlation between cFAP
Externí odkaz:
https://doaj.org/article/f1745d1ee4c94a02bdd005d616eb8aec
Autor:
Fiona M. Keane, Tsun-Wen Yao, Stefanie Seelk, Margaret G. Gall, Sumaiya Chowdhury, Sarah E. Poplawski, Jack H. Lai, Youhua Li, Wengen Wu, Penny Farrell, Ana Julia Vieira de Ribeiro, Brenna Osborne, Denise M.T. Yu, Devanshi Seth, Khairunnessa Rahman, Paul Haber, A. Kemal Topaloglu, Chuanmin Wang, Sally Thomson, Annemarie Hennessy, John Prins, Stephen M. Twigg, Susan V. McLennan, Geoffrey W. McCaughan, William W. Bachovchin, Mark D. Gorrell
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 43-54 (2014)
The protease fibroblast activation protein (FAP) is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. A specific, reliable FAP enzyme assay has been lacking. FAP's unique and restricted cleavage of the post proline
Externí odkaz:
https://doaj.org/article/699a5667312a445ea11703a45af02b69
Autor:
Mark D. Gorrell, Geoffrey W. McCaughan, Pok Fai Wong, Fiona M. Keane, Margaret G. Gall, William W. Bachovchin
Publikováno v:
Peptides. 75:80-95
Fibroblast activation protein (FAP) is a dipeptidyl peptidase (DPP) and endopeptidase that is weakly expressed in normal adult human tissues but is greatly up-regulated in activated mesenchymal cells of tumors and chronically injured tissue. The iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40a7d130a20360f066610a2fb04b20a
https://doi.org/10.1016/j.peptides.2015.11.004
https://doi.org/10.1016/j.peptides.2015.11.004
Autor:
Stefan Tholen, Geoffrey W. McCaughan, Quintin Lee, Stephen M. Twigg, Sumaiya Chowdhury, Elizabeth J. Hamson, Charles G. Bailey, Oliver Schilling, Ben Roediger, Maria Magdalena Koczorowska, Martin L. Biniossek, Angelina J. Lay, Hui Emma Zhang, Fiona M. Keane, Mark D. Gorrell, Matthew B. O'Rourke
Publikováno v:
Molecularcellular proteomics : MCP. 18(1)
Fibroblast activation protein-alpha (FAP) is a cell-surface transmembrane-anchored dimeric protease. This unique, constitutively active serine protease has both dipeptidyl aminopeptidase and endopeptidase activities and can hydrolyze the post-proline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae3c5816d17644e54383edbb4ad4a27
https://pubmed.ncbi.nlm.nih.gov/30257879
https://pubmed.ncbi.nlm.nih.gov/30257879
Autor:
Josie Lawrence, Sadiqa Maqsudi, Andrew N. Stephens, Adam Rainczuk, Fiona M. Keane, Mark D. Gorrell, Hui Zhang, Daniela Justa-Schuch, Ruth Geiss-Friedlander, Nadine Duffield
Publikováno v:
FEBS Journal. 282:3737-3757
Dipeptidyl peptidase 9 (DPP9) is a member of the S9B/DPPIV (DPP4) serine protease family, which cleaves N-terminal dipeptides at an Xaa-Pro consensus motif. Cytoplasmic DPP9 has roles in epidermal growth factor signalling and in antigen processing, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1df19e02da27bd9103630e87dd0181
https://doi.org/10.1111/febs.13371
https://doi.org/10.1111/febs.13371
Autor:
David G. Bowen, Fiona M. Keane, Geoffrey W. McCaughan, Mark D. Gorrell, Bharvi Maneck, H. Emma Zhang, Dingeman C. Rijken, Shirley Uitte de Willige, Frank W.G. Leebeek, Joyce J. M. C. Malfliet
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178987 (2017)
PLoS ONE
PLoS One (print), 12(6):e0178987. Public Library of Science
PLoS ONE
PLoS One (print), 12(6):e0178987. Public Library of Science
Background and aim Circulating fibroblast activation protein (cFAP) is a constitutively active enzyme expressed by activated fibroblasts that has both dipeptidyl peptidase and endopeptidase activities. We aimed to assess the correlation between cFAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5583e98fed0be57acf8c64649687b030
http://europepmc.org/articles/PMC5459491?pdf=render
http://europepmc.org/articles/PMC5459491?pdf=render
Autor:
Stephen M. Twigg, Emilia Prakoso, Erika Cavanagh, Geoffrey W. McCaughan, Jim Raleigh, Anne-Sophie Veillard, Mark D. Gorrell, Belinda A. Brooks, Nicholas A. Shackel, Amany Zekry, Fiona M. Keane, Ana Julia Vieira de Ribeiro, Susan V. McLennan, Kathryn Williams, Yangmin Bu
Publikováno v:
Journal of Diabetes. 7:809-819
Background Intrahepatic expression of dipeptidyl peptidase-4 (DPP4), and circulating DPP4 (cDPP4) levels and its enzymatic activity, are increased in non-alcoholic fatty liver disease (NAFLD) and in type 2 diabetes mellitus and/or obesity. DPP4 has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9263c4061fab73a1a80af32bb22334f
https://doi.org/10.1111/1753-0407.12237
https://doi.org/10.1111/1753-0407.12237
Publikováno v:
PROTEOMICS - Clinical Applications. 8:454-463
Fibroblast activation protein (FAP) is best known for its heightened expression in tumour stroma. This atypical serine protease has both dipeptidyl peptidase and endopeptidase activities, cleaving substrates at a post-proline bond. FAP expression is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f06142833666f4f553796e5e09c1502
https://doi.org/10.1002/prca.201300095
https://doi.org/10.1002/prca.201300095
Autor:
Penny Farrell, Susan V. McLennan, Brenna Osborne, Denise M. T. Yu, Sumaiya Chowdhury, Wengen Wu, Devanshi Seth, Stefanie Seelk, Annemarie Hennessy, Mark D. Gorrell, Fiona M. Keane, Paul S. Haber, Chuanmin Wang, Ana Julia Vieira de Ribeiro, Margaret G. Gall, A. Kemal Topaloglu, Tsun-Wen Yao, Jack H. Lai, Sarah E. Poplawski, Geoffrey W. McCaughan, Stephen M. Twigg, William W. Bachovchin, Sally Thomson, John Prins, Khairunnessa Rahman, Youhua Li
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 43-54 (2014)
FEBS Open Bio
FEBS Open Bio
The protease fibroblast activation protein (FAP) is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. A specific, reliable FAP enzyme assay has been lacking. FAP's unique and restricted cleavage of the post proline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1e57a056f3e8d53722a1da52bd7d11
http://www.sciencedirect.com/science/article/pii/S2211546313000752
http://www.sciencedirect.com/science/article/pii/S2211546313000752
Publikováno v:
Molecular Cancer Research. 11:1487-1496
DPP8 and DPP9 are recently identified members of the dipeptidyl peptidase IV (DPPIV) enzyme family, which is characterized by the rare ability to cleave a post-proline bond two residues from the N-terminus of a substrate. DPP8 and DPP9 have unique ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346527e4ad8fd970f02116ab02aef2de
https://doi.org/10.1158/1541-7786.mcr-13-0272
https://doi.org/10.1158/1541-7786.mcr-13-0272