Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Fiona M Deane"'
Autor:
Fiona M. Deane, Andrew J. S. Lin, Peter G. Hains, Sarah L. Pilgrim, Phillip J. Robinson, Adam McCluskey
Publikováno v:
ACS Omega, Vol 2, Iss 7, Pp 3828-3838 (2017)
Externí odkaz:
https://doaj.org/article/13b7928be0ea4fb1904544dc5a3aab77
Autor:
Luke R Odell, Nigel C. Jones, Ngoc Chau, Mark J. Robertson, Joseph I Ambrus, Fiona M Deane, Kelly A. Young, Ainslie Whiting, Jing Xue, Kate Prichard, James A. Daniel, Nick N. Gorgani, Terence J O'brien, Phillip J Robinson, Adam McCluskey
Publikováno v:
RSC Medicinal Chemistry.
We show that dansylcadaverine (1) a known in-cell inhibitor of clathrin mediated endocytosis (CME), moderately inhibits dynamin I (dynI) GTPase activity (IC50 45 μM) and transferrin (Tfn) endocytosis in U2OS...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1cdf45c9370444e924500dfa5f6b2a
https://doi.org/10.1039/d2md00371f
https://doi.org/10.1039/d2md00371f
Autor:
Ahmed Al Otaibi, Adam McCluskey, Cecilia C. Russell, Lacey Hizartzidis, Fiona M. Deane, Jennette A. Sakoff, Siobhann N. McCluskey
Publikováno v:
RSC Advances. 9:7652-7663
The Ugi four component reaction of an aldehyde, amine, isocyanide and an ethanoic acid was effected smoothly in protic ionic liquids ethylammonium nitrate (EAN) and propylammonium nitrate (PAN) to afford analogues of α-phenylacetamido amides in good
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63c82728fffbfcace601fe71fcddae3
https://doi.org/10.1039/c9ra00118b
https://doi.org/10.1039/c9ra00118b
Autor:
Phillip J. Robinson, Andrew J. S. Lin, Peter G. Hains, Adam McCluskey, Sarah L. Pilgrim, Fiona M. Deane
Publikováno v:
ACS Omega, Vol 2, Iss 7, Pp 3828-3838 (2017)
ACS Omega
ACS Omega
The effects of compound loading on the identification of protein kinases (PKs) was examined using two previously reported sepharose-supported PK inhibitors (PKIs): bisindolylmaleimide X (S1) and CZC8004 (S2). Compound loadings of 0.1, 0.5, 2.5, 5, 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb1feca4c772bfe9207a95b279d3368
https://doaj.org/article/13b7928be0ea4fb1904544dc5a3aab77
https://doaj.org/article/13b7928be0ea4fb1904544dc5a3aab77
Autor:
Danielle R. Bond, Joshua S. Brzozowski, Judith Weidenhofer, Mark Tarleton, Christopher J. Scarlett, Melanie J. Predebon, Aron A Shaw, Michael C. Bowyer, Fiona M. Deane, Adam McCluskey, Helen Jankowski
Publikováno v:
Molecules, Vol 24, Iss 3, p 524 (2019)
Molecules
Volume 24
Issue 3
Molecules
Volume 24
Issue 3
Pancreatic cancer (PC) is a complex, heterogeneous disease with a dismal prognosis. Current therapies have failed to improve survival outcomes, urging the need for discovery of novel targeted treatments. Bispidinone derivatives have yet to be investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa574b458635b630b4d14661f0006b63
https://www.mdpi.com/1420-3049/24/3/524
https://www.mdpi.com/1420-3049/24/3/524
Autor:
Volker Haucke, Lisa von Kleist, Mark J. Robertson, Adam McCluskey, Wiebke Stahlschmidt, Phillip J. Robinson, Fiona M. Deane
Publikováno v:
Nature Protocols. 9:1592-1606
This protocol describes the synthesis of two classes of clathrin inhibitors, Pitstop 1 and Pitstop 2, along with two inactive analogs that can be used as negative controls (Pitstop inactive controls, Pitnot-2 and Pitnot-2-100). Pitstop-induced inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ce734a2f41f852aa3918f10fae20a6
https://doi.org/10.1038/nprot.2014.106
https://doi.org/10.1038/nprot.2014.106
Autor:
Anna Mariana, Jennette A. Sakoff, Kelly A. Young, Luke R. Odell, Jayne Gilbert, Timothy A. Hill, Damien J. Keating, Aimee E. Novelle, Nick N. Gorgani, Phillip J. Robinson, Ngoc Chau, Megan Chircop, Ellen M. van Dam, James A. Daniel, Fiona M. Deane, Michael A. Cousin, Ainslie Whiting, Adam McCluskey, Annie Quan, Swetha Perera, Andrew B. McGeachie
Publikováno v:
ACS Chemical Biology. 8:1507-1518
Dynamin is required for clathrin-mediated endocytosis (CME). Its GTPase activity is stimulated by phospholipid binding to its PH domain, which induces helical oligomerization. We have designed a series of novel pyrimidine-based "Pyrimidyn" compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e91e1ed80da1877f3552c09606e540c
https://doi.org/10.1021/cb400137p
https://doi.org/10.1021/cb400137p
Publikováno v:
Journal of Heterocyclic Chemistry. 48:814-823
The improved synthesis of the compounds (III), (IX), and (XIV), which are key intermediates in the synthesis of ellipticines (VII) and its derivatives, e.g. (XII), is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc600f88691a9f3773b3d8f63aea575a
https://doi.org/10.1002/jhet.598
https://doi.org/10.1002/jhet.598
Autor:
Florence O. McCarthy, Rachel L. Clark, Blair F. Johnston, Fiona M. Deane, Simon P. Mackay, Nahoum G. Anthony
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:4741-4752
The benzo[c]phenanthridines (BCPs) are a group of compounds that are believed to express their antitumor activity through the inhibition of topoisomerase I. The enzyme is crucial to cell cycle division and progression, and regulates the equilibrium b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781c2ceb6e98ce37e60e5d9e953ae5eb
https://doi.org/10.1016/j.bmc.2007.05.002
https://doi.org/10.1016/j.bmc.2007.05.002
Publikováno v:
Nature protocols. 9(4)
Dynamin is a large GTPase with roles in membrane fission during clathrin-mediated endocytosis, in actin dynamics and in cytokinesis. Defects in dynamin have been linked to human diseases. The synthesis of a dynamin modulator toolkit comprising two di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bd24639d0223d56ee57ab490e773a9
https://pubmed.ncbi.nlm.nih.gov/24651498
https://pubmed.ncbi.nlm.nih.gov/24651498