Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Fiona J. Plunkett"'
Autor:
Lisa M. DeTora, Dikran Toroser, Angela Sykes, Christine Vanderlinden, Fiona J. Plunkett, Trevor Lane, Eline Hanekamp, Laura Dormer, Faith DiBiasi, Dan Bridges, Lise Baltzer, Leslie Citrome
Publikováno v:
Annals of Internal Medicine. 175:1298-1304
These updated Good Publication Practice (GPP) guidelines include recommendations for publishing company-sponsored biomedical research. The GPP guidelines apply to peer-reviewed or peer-oriented biomedical publications, such as manuscripts, meeting pr
Autor:
Joanne E. Cook, Maria V. D. Soares, Jeff M. Faint, Arne N. Akbar, W. Bergler, Jean M. Fletcher, Peter C. L. Beverley, Nicholas Hammerschmitt, Fiona J. Plunkett, Malcolm H.A. Rustin, Mike Salmon, Lavina L. Belaramani, Caroline S. Verbeke
Human-virus-specific CD8+ T cells that are found during primary infection have been studied almost exclusively in the peripheral blood, and it is unclear whether these cells are regulated in the same way as those in secondary lymphoid tissue. We inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cd768401fc38e0795a4073d8419319
https://doi.org/10.1182/blood-2003-06-1791
https://doi.org/10.1182/blood-2003-06-1791
Autor:
Richard Macaulay, Maria V. D. Soares, Arne N. Akbar, Sian M. Henson, Valentina Libri, Hanspeter Pircher, Fiona J. Plunkett, Ornella Franzese, Sorena Kiani-Alikhan, Sarah E. Jackson, Stephen J. Griffiths, Rita I. Azevedo, Joanne E. Masters
Publikováno v:
Blood. 113:6619-6628
Highly differentiated CD8+CD28−CD27− T cells have short telomeres, defective telomerase activity, and reduced capacity for proliferation, indicating that they are close to replicative senescence. In addition, these cells express increased levels
Autor:
Fiona J. Plunkett, Helene Margaret Finney, Matthew Hoare, Mala K. Maini, A. Ross Lopes, Arne N. Akbar, Graeme J.M. Alexander, Abhishek Das, Patrick T F Kennedy, Claire Dunn, Alistair Lawson, Nathan Davies, Antonio Bertoletti
Publikováno v:
The Journal of Experimental Medicine
The inflamed liver in chronic hepatitis B virus (HBV) infection (CHB) is characterized by a large influx of non–virus-specific CD8 T cells. Little is known about the functional capacity of these lymphocytes, which could provide insights into mechan
Autor:
Andrew D. Hislop, Alan B. Rickinson, K. Ivory, Fiona J. Plunkett, Mike Salmon, Mark W. Lowdell, Nicola E. Annels, Arne N. Akbar, Maria V. D. Soares
Publikováno v:
Blood. 97:700-707
Acute infectious mononucleosis (AIM) induced by Epstein-Barr virus (EBV) infection is characterized by extensive expansion of antigen-specific CD8+ T cells. One potential consequence of this considerable proliferative activity is telomere shortening,
Publikováno v:
Mechanisms of Ageing and Development. 121:69-76
The cytotoxic CD8+ T cell population expands considerably during acute immune infection with virus. Most of these cells are removed by apoptosis at the end of the immune response. However, a balance has to be attained between clearance and retention
Publikováno v:
APOPTOSIS. 5:431-734
Viral infections are characterised by a large expansion of CD8+ effector T cells. Once generated, these T cells must be cleared and homeostasis re-established. In this review we describe two mechanisms, apoptosis and replicative senescence which are
Autor:
Arne N. Akbar, Nening M. Nanlohy, Sigrid A. Otto, Fiona J. Plunkett, Debbie van Baarle, Jean M. Fletcher
Publikováno v:
The Journal of infectious diseases. 198(9)
Individuals infected with human immunodeficiency virus (HIV) have low numbers of functional Epstein-Barr virus (EBV)-specific CD8+ T cells in the face of a high EBV load, suggesting that these cells have become exhausted. We investigated whether the
Autor:
Helene Margaret Finney, Lavina L. Belaramani, Mike Salmon, Alastair David Griffiths Lawson, Jean M. Fletcher, Arne N. Akbar, Inderjeet Dokal, Fiona J. Plunkett, Ornella Franzese, David Webster
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 178(12)
The enzyme telomerase is essential for maintaining the replicative capacity of memory T cells. Although CD28 costimulatory signals can up-regulate telomerase activity, human CD8+ T cells lose CD28 expression after repeated activation. Nevertheless, t
Autor:
Fiona J. Plunkett, Pádraic J. Dunne, Nicola E. Annels, Andrew D. Hislop, Jeffery M. Faint, Maria V. D. Soares, Alan B. Rickinson, Jean M. Fletcher, Arne N. Akbar, Mike Salmon, Nancy H. Gudgeon
Publikováno v:
Blood. 100(3)
During acute infection, latent and lytic Epstein-Barr virus (EBV) epitope-specific CD8+ T cells have a CD45RO+CD45RA− phenotype. However, after resolution of the infection, a large proportion of these cells, particularly those specific for lytic vi