Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Fiona J. Houghton"'
Autor:
Stanley C. Xie, Riley D. Metcalfe, Elyse Dunn, Craig J. Morton, Shih-Chung Huang, Tanya Puhalovich, Yawei Du, Sergio Wittlin, Shuai Nie, Madeline R. Luth, Liting Ma, Mi-Sook Kim, Charisse Flerida A. Pasaje, Krittikorn Kumpornsin, Carlo Giannangelo, Fiona J. Houghton, Alisje Churchyard, Mufuliat T. Famodimu, Daniel C. Barry, David L. Gillett, Sumanta Dey, Clara C. Kosasih, William Newman, Jacquin C. Niles, Marcus C. S. Lee, Jake Baum, Sabine Ottilie, Elizabeth A. Winzeler, Darren J. Creek, Nicholas Williamson, Michael W. Parker, Stephen Brand, Steven P. Langston, Lawrence R. Dick, Michael D.W. Griffin, Alexandra E. Gould, Leann Tilley
Publikováno v:
Science. 376:1074-1079
Aminoacyl transfer RNA (tRNA) synthetases (aaRSs) are attractive drug targets, and we present class I and II aaRSs as previously unrecognized targets for adenosine 5′-monophosphate–mimicking nucleoside sulfamates. The target enzyme catalyzes the
Publikováno v:
Molecular Biology of the Cell. 34
Arf5 is identified as a novel interaction partner with the mTORC1 subunit, Raptor, and a regulator of mTORC1 signaling at PM ruffles. The findings reveal a Arf5-dependent pathway for recruitment and activation of mTORC1 at PM ruffles, a process relev
Autor:
Fiona J. Houghton, Christian Makhoul, Ellie Hyun‐Jung Cho, Nicholas A. Williamson, Paul A. Gleeson
Publikováno v:
FEBS lettersReferences. 596(18)
The small G protein Arl5b is localised on the trans-Golgi network (TGN) and regulates endosomes-to-TGN transport. Here, we combined in vivo and in vitro techniques to map the interactive partners and near neighbours of Arl5b at the TGN, using constit
Autor:
Fiona J. Houghton, Anne M Verhagen, Elizabeth Hinde, Paul A. Gleeson, Steven K. Dower, Andreas Pannek
Publikováno v:
Molecular biology of the cell. 33(1)
The neonatal Fc receptor (FcRn) is responsible for the recycling of endocytosed albumin and IgG, and contributes to their long plasma half-life. We recently identified an FcRn-dependent recycling pathway from macropinosomes in macrophages; however, l
Publikováno v:
Experimental Cell Research. 380:55-68
The small GTPases Rab11a and 11b are key regulators of membrane transport, localised to the recycling endosomes and also early endosomes. The function of Rab11 within the recycling pathway has been well defined, however, the role of Rab11 at the earl
Publikováno v:
Traffic. 18:159-175
The intracellular trafficking and proteolytic processing of the membrane-bound amyloid precursor protein (APP) are coordinated events leading to the generation of pathogenic amyloid-beta (Aβ) peptides. The membrane transport of newly synthesized APP
Autor:
Ismail S. Mahmoud, Khalisah L Zulkefli, Fiona J. Houghton, Paul A. Gleeson, Prajakta Gosavi, Nicholas A. Williamson
Publikováno v:
Experimental Cell Research. 399:112442
Rab30 is a poorly characterized small GTPase. Here we show that Rab30 is localised primarily to the TGN and recycling endosomes in a range of cell types, including primary neurons; minor levels of Rab30 were also detected throughout the Golgi stack a
Publikováno v:
Journal of cell science. 131(3)
In vertebrates, individual Golgi stacks are joined into a compact ribbon structure; however, the relevance of a ribbon structure has been elusive. Here, we exploit the finding that the membrane tether of the trans-Golgi network, GCC88 (encoded by GCC
Autor:
Paul A. Gleeson, Dorothée Bourges, Simon Read, Ellen M. Ross, Louis Boon, Fiona J. Houghton, Ian R. van Driel, Sammy Bedoui, Stacey M. Allen
Publikováno v:
The Journal of Immunology. 192:5023-5030
It has been proposed that activation of dendritic cells (DCs) presenting self-antigens during inflammation may lead to activation of autoreactive T cells and the development of autoimmunity. To test this hypothesis, we examined the presentation of th
High-Throughput Quantitation of Intracellular Trafficking and Organelle Disruption by Flow Cytometry
Publikováno v:
Traffic. 15:572-582
Current methods for the quantitation of membrane protein trafficking rely heavily on microscopy, which has limited quantitative capacity for analyses of cell populations and is cumbersome to perform. Here we describe a simple flow cytometry-based met