Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Fiona J McDonald"'
Autor:
Michael D Healy, Manuela K Hospenthal, Ryan J Hall, Mintu Chandra, Molly Chilton, Vikas Tillu, Kai-En Chen, Dion J Celligoi, Fiona J McDonald, Peter J Cullen, J Shaun Lott, Brett M Collins, Rajesh Ghai
Publikováno v:
eLife, Vol 7 (2018)
The COMMD proteins are a conserved family of proteins with central roles in intracellular membrane trafficking and transcription. They form oligomeric complexes with each other and act as components of a larger assembly called the CCC complex, which
Externí odkaz:
https://doaj.org/article/52ef44e3fdd642e78e446da5ae0c2ac6
Autor:
Dominik Wiemuth, J Shaun Lott, Kevin Ly, Ying Ke, Paul Teesdale-Spittle, Peter M Snyder, Fiona J McDonald
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12163 (2010)
The epithelial sodium channel (ENaC) is an integral component of the pathway for Na(+) absorption in epithelial cells. The ubiquitin ligases Nedd4 and Nedd4-2 bind to ENaC and decrease its activity. Conversely, Serum- and Glucocorticoid regulated Kin
Externí odkaz:
https://doaj.org/article/ff2bb5970fdd4679befbf075098e8b88
Autor:
Rachel E. Farquhar, Tanya T. Cheung, Matthew J. E. Logue, Fiona J. McDonald, Daniel C. Devor, Kirk L. Hamilton
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Targeting proteins to a specific membrane is crucial for proper epithelial cell function. KCa3.1, a calcium-activated, intermediate-conductance potassium channel, is targeted to the basolateral membrane (BLM) in epithelial cells. Surprisingly, the me
Externí odkaz:
https://doaj.org/article/4b2b30470aed44848c4189e190b20ed3
Publikováno v:
Breast Cancer Research and Treatment. 187:31-43
Breast cancer is the most common cancer affecting women worldwide with half a million associated deaths annually. Despite a huge global effort, the pathways of breast cancer progression are not fully elucidated. Ion channels have recently emerged as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71781dee393679199d082de09c77f295
https://doi.org/10.1007/s10549-021-06133-7
https://doi.org/10.1007/s10549-021-06133-7
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H487-H493
Vascular epithelial sodium channels (ENaCs) made up of canonical α, β, and γ subunits have attracted more attention recently owing to their physiological role in vascular health and disease. A fourth subunit, δ-ENaC, is expressed in various mamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c44118b1436aa7899205038a17f710df
https://doi.org/10.1152/ajpheart.00800.2020
https://doi.org/10.1152/ajpheart.00800.2020
Autor:
Puja Paudel, Isabelle van Hout, Richard W. Bunton, Dominic J. Parry, Sean Coffey, Fiona J. McDonald, Martin Fronius
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 79(7)
Background: Elevated expression and increased activity of vascular epithelial sodium channel (ENaC) can result in vascular dysfunction in small animal models. However, there is limited or no knowledge on expression and function of ENaC channels in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e30266eab5ebeb5d674de00141f186
https://pubmed.ncbi.nlm.nih.gov/35510563
https://pubmed.ncbi.nlm.nih.gov/35510563
Autor:
Tanya T. Cheung, Polly Tenci, Adam W. Ware, Fiona J. McDonald, Sahib R. Rasulov, Kirk L. Hamilton, Anna C Geda
Publikováno v:
American Journal of Physiology-Renal Physiology. 319:F895-F907
The epithelial Na+ channel (ENaC) located at the apical membrane in many epithelia is the rate-limiting step for Na+ reabsorption. Tight regulation of the plasma membrane population of ENaC is required, as hypertension or hypotension may result if to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da2713cfc5ee2cb2687a762aaaecc136
https://doi.org/10.1152/ajprenal.00198.2019
https://doi.org/10.1152/ajprenal.00198.2019
Publikováno v:
American Journal of Physiology-Renal Physiology. 318:F1-F13
Renal Na+reabsorption, facilitated by the epithelial Na+channel (ENaC), is subject to multiple forms of control to ensure optimal body blood volume and pressure through altering both the ENaC population and activity at the cell surface. Here, the foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::351a724086fecda5e1b3ae53c46d83e7
https://doi.org/10.1152/ajprenal.00277.2019
https://doi.org/10.1152/ajprenal.00277.2019
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::314cd17de96b6bf0f8d4a39f748f885e
https://doi.org/10.1096/fasebj.2021.35.s1.05028
https://doi.org/10.1096/fasebj.2021.35.s1.05028
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf9b6797f0ecf7c57b97d4518a7bd0b8
https://doi.org/10.1096/fasebj.2021.35.s1.02945
https://doi.org/10.1096/fasebj.2021.35.s1.02945