Attenuated Salmonella Typhimurium lacking the pathogenicity island-2 type 3 secretion system grow to high bacterial numbers inside phagocytes in mice.

Autor: Andrew J Grant, Fiona J E Morgan, Trevelyan J McKinley, Gemma L Foster, Duncan J Maskell, Pietro Mastroeni

Publikováno v: PLoS Pathogens, Vol 8, Iss 12, p e1003070 (2012)

Intracellular replication within specialized vacuoles and cell-to-cell spread in the tissue are essential for the virulence of Salmonella enterica. By observing infection dynamics at the single-cell level in vivo, we have discovered that the Salmonel

Externí odkaz: https://doaj.org/article/d5f23b68bb2f4d91ad3fca2e7cf405d2

Emergence of methicillin resistance predates the clinical use of antibiotics

Autor: Jesper Larsen, Claire L. Raisen, Xiaoliang Ba, Nicholas J. Sadgrove, Guillermo F. Padilla-González, Monique S. J. Simmonds, Igor Loncaric, Heidrun Kerschner, Petra Apfalter, Rainer Hartl, Ariane Deplano, Stien Vandendriessche, Barbora Černá Bolfíková, Pavel Hulva, Maiken C. Arendrup, Rasmus K. Hare, Céline Barnadas, Marc Stegger, Raphael N. Sieber, Robert L. Skov, Andreas Petersen, Øystein Angen, Sophie L. Rasmussen, Carmen Espinosa-Gongora, Frank M. Aarestrup, Laura J. Lindholm, Suvi M. Nykäsenoja, Frederic Laurent, Karsten Becker, Birgit Walther, Corinna Kehrenberg, Christiane Cuny, Franziska Layer, Guido Werner, Wolfgang Witte, Ivonne Stamm, Paolo Moroni, Hannah J. Jørgensen, Hermínia de Lencastre, Emilia Cercenado, Fernando García-Garrote, Stefan Börjesson, Sara Hæggman, Vincent Perreten, Christopher J. Teale, Andrew S. Waller, Bruno Pichon, Martin D. Curran, Matthew J. Ellington, John J. Welch, Sharon J. Peacock, David J. Seilly, Fiona J. E. Morgan, Julian Parkhill, Nazreen F. Hadjirin, Jodi A. Lindsay, Matthew T. G. Holden, Giles F. Edwards, Geoffrey Foster, Gavin K. Paterson, Xavier Didelot, Mark A. Holmes, Ewan M. Harrison, Anders R. Larsen

Publikováno v: Larsen, Jesper; Raisen, Claire L; Ba, Xiaoliang; Sadgrove, Nicholas J; Padilla-González, Guillermo F; Simmonds, Monique S J; Loncaric, Igor; Kerschner, Heidrun; Apfalter, Petra; Hartl, Rainer; Deplano, Ariane; Vandendriessche, Stien; Černá Bolfíková, Barbora; Hulva, Pavel; Arendrup, Maiken C; Hare, Rasmus K; Barnadas, Céline; Stegger, Marc; Sieber, Raphael N; Skov, Robert L; ... (2022). Emergence of methicillin resistance predates the clinical use of antibiotics. Nature, 602(7895), pp. 135-141. Springer Nature Limited 10.1038/s41586-021-04265-w
Larsen, J, Raisen, C L, Sadgrove, N J, Padilla-González, G F, Simmonds, M S J, Loncaric, I, Kerschner, H, Apfalter, P, Hartl, R, Ariane Deplano, A, Vandendriessche, S, Bolfíková, B Č, Hulva, P, Arendrup, M C, Hare, R K, Barnadas, C, Stegger, M, Sieber, R N, Skov, R L, Petersen, A, Angen, Ø, Rasmussen, S L, Espinosa-Gongora, C, Aarestrup, F M, Lindholm, L, Nykäsenoja, S, Laurent, F, Becker, K, Walther, B, Kehrenberg, C, Cuny, C, Layer, F, Werner, G, Witte, W, Stamm, I, Moroni, P, Jørgensen, H, de Lencastre, H, Cercenado, E, García-Garrote, F, Börjesson, S, Hæggman, S, Perreten, V, J. Teale, C, Waller, A, Pichon, B, Curran, M, Ellington, M, Welch, J, Peacock, S, Seilly, D, Morgan, F, Parkhill, J, Hadjirin, N, Lindsay, J, Holden, M T G, Edwards, G F, Foster, G, Paterson, G, Didelot, X, Holmes, M, Harrison, E & Larsen, A R 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, no. 7895, pp. 135-141 . https://doi.org/10.1038/s41586-021-04265-w
Larsen, J, Raisen, C L, Ba, X, Sadgrove, N J, Padilla-González, G F, Simmonds, M S J, Loncaric, I, Kerschner, H, Apfalter, P, Hartl, R, Deplano, A, Vandendriessche, S, Černá Bolfíková, B, Hulva, P, Arendrup, M C, Hare, R K, Barnadas, C, Stegger, M, Sieber, R N, Skov, R L, Petersen, A, Angen, Ø, Rasmussen, S L, Espinosa-Gongora, C, Aarestrup, F M, Lindholm, L J, Nykäsenoja, S M, Laurent, F, Becker, K, Walther, B, Kehrenberg, C, Cuny, C, Layer, F, Werner, G, Witte, W, Stamm, I, Moroni, P, Jørgensen, H J, de Lencastre, H, Cercenado, E, García-Garrote, F, Börjesson, S, Hæggman, S, Perreten, V, Teale, C J, Waller, A S, Pichon, B, Curran, M D, Ellington, M J, Welch, J J, Peacock, S J, Seilly, D J, Morgan, F J E, Parkhill, J, Hadjirin, N F, Lindsay, J A, Holden, M T G, Edwards, G F, Foster, G, Paterson, G K, Didelot, X, Holmes, M A, Harrison, E M & Larsen, A R 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, pp. 135–141 . https://doi.org/10.1038/s41586-021-04265-w
Paterson, G K 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, pp. 135-141 . https://doi.org/10.1038/s41586-021-04265-w

X.D. was funded by a grant from the National Institute for Health Research (NIHR) Health Protection Research Unit in Genomics and Enabling Data (no. NIHR200892). M.A.H. was supported by grants from the Medical Research Council (nos. G1001787/1, MR/N0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c43e8cd39a109234141bcbc266c126

The bacterial cytoskeleton modulates motility, type 3 secretion, and colonization in Salmonella

Autor: Michail H. Karavolos, Pietro Mastroeni, Lubna Kharraz, David M. Bulmer, Emma J. McGhie, Fiona J. E. Morgan, Paul Dean, Andrew J. Grant, Anne C. Doble, Vassilis Koronakis, Richard A. Daniel, C. M. Anjam Khan

Publikováno v: PLoS Pathogens, Vol 8, Iss 1, p e1002500 (2012)
PLoS Pathogens

Although there have been great advances in our understanding of the bacterial cytoskeleton, major gaps remain in our knowledge of its importance to virulence. In this study we have explored the contribution of the bacterial cytoskeleton to the abilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c9c9b343cebceab62e914a8246c9d8

Prevalence and characterization of human mecC methicillin-resistant Staphylococcus aureus isolates in England

Autor: Edward J. P. Cartwright, Sharon J. Peacock, Ewan M. Harrison, Fiona J. E. Morgan, Ruth N. Zadoks, Mark A. Holmes, M. E. Török, Julian Parkhill, Gavin K. Paterson

Publikováno v: Journal of Antimicrobial Chemotherapy. 69:907-910

Objectives: There are limited data available on the epidemiology and prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in the human population that encode the recently described mecA homologue, mecC. To address this knowledge gap we un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb53c4daecb6c5302e6d48b2240517d2
https://doi.org/10.1093/jac/dkt462

In Vivo Regulation of the Vi Antigen in Salmonella and Induction of Immune Responses with an In Vivo -Inducible Promoter

Autor: Victoria F. John, Robert A. Kingsley, Gordon Dougan, Carole Janis, Andrew J. Grant, Jenny Houghton, Fiona J. E. Morgan, Trevelyan J. McKinley, Pietro Mastroeni

Publikováno v: Infection and Immunity. 79:2481-2488

Salmonella enterica serovar Typhi, the agent of typhoid fever in humans, expresses the surface Vi polysaccharide antigen that contributes to virulence. However, Vi expression can also be detrimental to some key steps of S. Typhi infectivity, for exam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ae91ed864e287926460fb27ea2356e
https://doi.org/10.1128/iai.01265-10