Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Fiona J, McDonald"'
Autor:
Rachel E. Farquhar, Tanya T. Cheung, Matthew J. E. Logue, Fiona J. McDonald, Daniel C. Devor, Kirk L. Hamilton
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Targeting proteins to a specific membrane is crucial for proper epithelial cell function. KCa3.1, a calcium-activated, intermediate-conductance potassium channel, is targeted to the basolateral membrane (BLM) in epithelial cells. Surprisingly, the me
Externí odkaz:
https://doaj.org/article/4b2b30470aed44848c4189e190b20ed3
Autor:
Lorna J. Daniels, Rachel S. Wallace, Olivia M. Nicholson, Genevieve A. Wilson, Fiona J. McDonald, Peter P. Jones, J. Chris Baldi, Regis R. Lamberts, Jeffrey R. Erickson
Publikováno v:
Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-15 (2018)
Abstract Background Calcium/calmodulin-dependent kinase II-delta (CaMKIIδ) activity is enhanced during hyperglycemia and has been shown to alter intracellular calcium handling in cardiomyocytes, ultimately leading to reduced cardiac performance. How
Externí odkaz:
https://doaj.org/article/7d5f0a7eb7e84e10a1bfb2fd61ba931a
Autor:
Tanya T. Cheung, Noor A. S. Ismail, Rachel Moir, Nikhil Arora, Fiona J. McDonald, Steven B. Condliffe
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The epithelial Na+ channel (ENaC) provides for Na+ absorption in various types of epithelia including the kidney, lung, and colon where ENaC is localized to the apical membrane to enable Na+ entry into the cell. The degree of Na+ entry via ENaC large
Externí odkaz:
https://doaj.org/article/310b30e61e364527a764899b5a271d06
Autor:
Michael D Healy, Manuela K Hospenthal, Ryan J Hall, Mintu Chandra, Molly Chilton, Vikas Tillu, Kai-En Chen, Dion J Celligoi, Fiona J McDonald, Peter J Cullen, J Shaun Lott, Brett M Collins, Rajesh Ghai
Publikováno v:
eLife, Vol 7 (2018)
The COMMD proteins are a conserved family of proteins with central roles in intracellular membrane trafficking and transcription. They form oligomeric complexes with each other and act as components of a larger assembly called the CCC complex, which
Externí odkaz:
https://doaj.org/article/52ef44e3fdd642e78e446da5ae0c2ac6
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Optimal function of the epithelial sodium channel (ENaC) in the distal nephron is key to the kidney’s long-term control of salt homeostasis and blood pressure. Multiple pathways alter ENaC cell surface populations, including correct processing and
Externí odkaz:
https://doaj.org/article/3a245959aaf14a8386629b64b32b840f
Publikováno v:
Breast Cancer Research and Treatment. 187:31-43
Breast cancer is the most common cancer affecting women worldwide with half a million associated deaths annually. Despite a huge global effort, the pathways of breast cancer progression are not fully elucidated. Ion channels have recently emerged as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71781dee393679199d082de09c77f295
https://doi.org/10.1007/s10549-021-06133-7
https://doi.org/10.1007/s10549-021-06133-7
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H487-H493
Vascular epithelial sodium channels (ENaCs) made up of canonical α, β, and γ subunits have attracted more attention recently owing to their physiological role in vascular health and disease. A fourth subunit, δ-ENaC, is expressed in various mamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c44118b1436aa7899205038a17f710df
https://doi.org/10.1152/ajpheart.00800.2020
https://doi.org/10.1152/ajpheart.00800.2020
Autor:
Puja Paudel, Isabelle van Hout, Richard W. Bunton, Dominic J. Parry, Sean Coffey, Fiona J. McDonald, Martin Fronius
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 79(7)
Background: Elevated expression and increased activity of vascular epithelial sodium channel (ENaC) can result in vascular dysfunction in small animal models. However, there is limited or no knowledge on expression and function of ENaC channels in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e30266eab5ebeb5d674de00141f186
https://pubmed.ncbi.nlm.nih.gov/35510563
https://pubmed.ncbi.nlm.nih.gov/35510563
Autor:
Tanya T. Cheung, Polly Tenci, Adam W. Ware, Fiona J. McDonald, Sahib R. Rasulov, Kirk L. Hamilton, Anna C Geda
Publikováno v:
American Journal of Physiology-Renal Physiology. 319:F895-F907
The epithelial Na+ channel (ENaC) located at the apical membrane in many epithelia is the rate-limiting step for Na+ reabsorption. Tight regulation of the plasma membrane population of ENaC is required, as hypertension or hypotension may result if to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da2713cfc5ee2cb2687a762aaaecc136
https://doi.org/10.1152/ajprenal.00198.2019
https://doi.org/10.1152/ajprenal.00198.2019
Publikováno v:
American Journal of Physiology-Renal Physiology. 318:F1-F13
Renal Na+reabsorption, facilitated by the epithelial Na+channel (ENaC), is subject to multiple forms of control to ensure optimal body blood volume and pressure through altering both the ENaC population and activity at the cell surface. Here, the foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::351a724086fecda5e1b3ae53c46d83e7
https://doi.org/10.1152/ajprenal.00277.2019
https://doi.org/10.1152/ajprenal.00277.2019