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pro vyhledávání: '"Fiona J, Flett"'
Autor:
Fiona J. Flett, Emilija Ruksenaite, Lee A. Armstrong, Shipra Bharati, Roberta Carloni, Elizabeth R. Morris, C. Logan Mackay, Heidrun Interthal, Julia M. Richardson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Human tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs covalently trapped topoisomerase 1B-DNA complexes and other lesions, and is a target for anticancer drug development. Here the authors use an integrated structural approach to shed light onto the m
Externí odkaz:
https://doaj.org/article/2dff6c27b8244f03bdfbb18f51738a7b
Publikováno v:
Analytical chemistry. 89(21)
Cross-linking of nucleic acids to proteins in combination with mass spectrometry permits the precise identification of interacting residues between nucleic acid-protein complexes. However, the mass spectrometric identification and characterization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22229734026e14cfa6acd638ecb245e3
https://pubmed.ncbi.nlm.nih.gov/28885003
https://pubmed.ncbi.nlm.nih.gov/28885003
Autor:
Fiona J, Flett, Emilija, Ruksenaite, Lee A, Armstrong, Shipra, Bharati, Roberta, Carloni, Elizabeth R, Morris, C Logan, Mackay, Heidrun, Interthal, Julia M, Richardson
Publikováno v:
Nature Communications
Tyrosyl-DNA phosphodiesterase (Tdp1) is a DNA 3′-end processing enzyme that repairs topoisomerase 1B-induced DNA damage. We use a new tool combining site-specific DNA–protein cross-linking with mass spectrometry to identify Tdp1 interactions with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48dec214d00824c13c0ed0e3bc8990f6
https://pubmed.ncbi.nlm.nih.gov/29295983
https://pubmed.ncbi.nlm.nih.gov/29295983
Publikováno v:
Analytical chemistry. 87(19)
UV cross-linking of nucleic acids to proteins in combination with mass spectrometry is a powerful technique to identify proteins, peptides, and the amino acids involved in intermolecular interactions within nucleic acid-protein complexes. However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6c567170f8e9043fcf84fa9333fb0a
https://pubmed.ncbi.nlm.nih.gov/26335278
https://pubmed.ncbi.nlm.nih.gov/26335278
Autor:
Heidrun Interthal, Fiona J Flett
Publikováno v:
Methods in Molecular Biology ISBN: 9781627035644
Denaturing urea polyacrylamide gel electrophoresis (PAGE) allows the separation of linear single-stranded DNA molecules based on molecular weight. This method can be used to analyze or purify short synthesized DNA oligonucleotides or products from en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::336f35850575ba48488395e4c3492a3a
https://doi.org/10.1007/978-1-62703-565-1_11
https://doi.org/10.1007/978-1-62703-565-1_11
