Expression of Endogenous Putative TSH Binding Protein in Orbit

Autor: Samuel Lewin Evans, D. Aled Rees, Mohd Shazli Draman, Anjana S Haridas, Colin M. Dayan, Fiona Grennan-Jones, Carol M. Lane, Ilaria Muller, Daniel S Morris, Lei Zhang, Marian Ludgate, Peter N. Taylor

Publikováno v: Current Issues in Molecular Biology, Vol 43, Iss 126, Pp 1794-1804 (2021)
Current Issues in Molecular Biology
Volume 43
Issue 3
Pages 126-1804

Thyroid stimulating antibodies (TSAB) cause Graves’ disease and contribute to Graves’ Orbitopathy (GO) pathogenesis. We hypothesise that the presence of TSH binding proteins (truncated TSHR variants (TSHRv)) and/or nonclassical ligands such as th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76bde4643d2c5a6bd55513419a70b15c
https://pubmed.ncbi.nlm.nih.gov/34889904

Possible Targets for Nonimmunosuppressive Therapy of Graves' Orbitopathy

Autor: Marian Ludgate, Mohd Shazli Draman, Fiona Grennan-Jones, Colin M. Dayan, Daniel S Morris, Lei Zhang, Carol M. Lane, Andrew R. Tee

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 99:E1183-E1190

Context: Graves' orbitopathy (GO) is caused by expansion of the orbital contents by excess adipogenesis and overproduction of hyaluronan (HA). Immunosuppressive and antiinflammatory treatments of GO are not always effective and can have side effects,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cf852c476e393d86f427e879361bdc
https://doi.org/10.1210/jc.2013-4182

Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue

Autor: Dafydd Aled Rees, Lei Zhang, Neera Agarwal, Samuel Peter Llewellyn Rice, M. D. Lewis, Marian Ludgate, Fiona Grennan-Jones

Publikováno v: Molecular and Cellular Endocrinology. 320:51-57

Dehydroepiandrosterone (DHEA), a precursor sex steroid, circulates in sulphated form (DHEAS). Serum DHEAS concentrations are inversely correlated with metabolic syndrome components and in vivo/in vitro studies suggest a role in modulating adipose mas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf3d5e169d9184e2c48e955e5d1152e
https://doi.org/10.1016/j.mce.2010.02.017

Gsα signalling suppresses PPARγ2 generation and inhibits 3T3L1 adipogenesis

Autor: Carol Ann Paddon, Marian Ludgate, Lei Zhang, M. D. Lewis, Fiona Grennan-Jones

Publikováno v: The Journal of Endocrinology

Since TSH receptor (TSHR) expression increases during adipogenesis and signals via cAMP/phospho-cAMP-response element binding protein (CREB), reported to be necessary and sufficient for adipogenesis, we hypothesised that TSHR activation would induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66ee6fc5977c75214fb0366c4f1f117
https://doi.org/10.1677/joe-09-0099

X-ray crystal structure of a monoclonal antibody that binds to a major autoantigenic epitope on thyroid peroxidase

Autor: Jadwiga Furmaniak, B. Rees Smith, J. Sanders, J. Godfrey, E. Hendry, Griffith Taylor, Michael Powell, N. Liddy, Andrew Sullivan, N. Hayakawa, Fiona Grennan-Jones

Publikováno v: Thyroid : official journal of the American Thyroid Association. 11(12)

Thyroid peroxidase (TPO) catalyzes the production of thyroid hormones and is a major autoantigen in autoimmune thyroid disease (AITD). It is believed that the majority of TPO autoantibodies bind to an immunodominant region consisting of two overlappi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d6987c58ecdc2d97bf525d927f8e99
https://pubmed.ncbi.nlm.nih.gov/12186495